全文获取类型
收费全文 | 113篇 |
免费 | 2篇 |
国内免费 | 2篇 |
专业分类
电工技术 | 4篇 |
综合类 | 17篇 |
化学工业 | 47篇 |
金属工艺 | 7篇 |
机械仪表 | 3篇 |
建筑科学 | 2篇 |
矿业工程 | 3篇 |
能源动力 | 1篇 |
轻工业 | 8篇 |
石油天然气 | 3篇 |
武器工业 | 1篇 |
无线电 | 4篇 |
一般工业技术 | 2篇 |
冶金工业 | 6篇 |
自动化技术 | 9篇 |
出版年
2023年 | 1篇 |
2022年 | 17篇 |
2021年 | 25篇 |
2020年 | 2篇 |
2017年 | 2篇 |
2016年 | 1篇 |
2015年 | 1篇 |
2014年 | 1篇 |
2012年 | 5篇 |
2011年 | 1篇 |
2010年 | 4篇 |
2009年 | 5篇 |
2008年 | 3篇 |
2007年 | 8篇 |
2006年 | 7篇 |
2005年 | 6篇 |
2004年 | 5篇 |
2003年 | 4篇 |
2002年 | 3篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1999年 | 2篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1995年 | 2篇 |
1993年 | 2篇 |
1991年 | 1篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1967年 | 1篇 |
1959年 | 1篇 |
排序方式: 共有117条查询结果,搜索用时 15 毫秒
1.
Ava Kwong Cecilia Y. S. Ho Vivian Y. Shin Chun Hang Au Tsun Leung Chan Edmond S. K. Ma 《International journal of molecular sciences》2021,22(2)
The germline carrier of the BRCA1 pathogenic mutation has been well proven to confer an increased risk of breast and ovarian cancer. Despite BRCA1 biallelic pathogenic mutations being extremely rare, they have been reported to be embryonically lethal or to cause Fanconi anemia (FA). Here we describe a patient who was a 48-year-old female identified with biallelic pathogenic mutations of the BRCA1 gene, with no or very subtle FA-features. She was diagnosed with ovarian cancer and breast cancer at the ages of 43 and 44 and had a strong family history of breast and gynecological cancers. 相似文献
2.
《青岛科技大学学报(自然科学版)》2010,(5)
给出1类重要的遗传余代数——正规的广义路余代数,在余代数上定义了3种二次型,证明了在Gabriel箭图是局部有限的遗传余代数上定义的这3种二次型一致。 相似文献
3.
基于Agent的遗传算法描述与演化模型研究 总被引:3,自引:0,他引:3
李凡长 《小型微型计算机系统》2003,24(1):118-122
Agent是指具有智能的人或其它智能物.它具有自治、反响、推测、协作、自学习和相互学习等能力,本文基于Darwin自然进化论与Mendel遗传变异理论,给出Agent的遗传算法与演化模型.这些理论的提出,进一步丰富和完善了Agent的研究内容. 相似文献
4.
Leber’s Hereditary Optic Neuropathy (LHON) is the most common primary mitochondrial DNA disorder. It is characterized by bilateral severe central subacute vision loss due to specific loss of Retinal Ganglion Cells and their axons. Historically, treatment options have been quite limited, but ongoing clinical trials show promise, with significant advances being made in the testing of free radical scavengers and gene therapy. In this review, we summarize management strategies and rational of treatment based on current insights from molecular research. This includes preventative recommendations for unaffected genetic carriers, current medical and supportive treatments for those affected, and emerging evidence for future potential therapeutics. 相似文献
5.
Vita etraj
i
Drago Ksenija Strojnik Gaper Klan
ar Petra kerl Vida Stegel Ana Blatnik Marta Banjac Mateja Krajc Srdjan Novakovi 《International journal of molecular sciences》2022,23(13)
Pathogenic/likely pathogenic variants in susceptibility genes that interrupt RNA splicing are a well-documented mechanism of hereditary cancer syndromes development. However, if RNA studies are not performed, most of the variants beyond the canonical GT-AG splice site are characterized as variants of uncertain significance (VUS). To decrease the VUS burden, we have bioinformatically evaluated all novel VUS detected in 732 consecutive patients tested in the routine genetic counseling process. Twelve VUS that were predicted to cause splicing defects were selected for mRNA analysis. Here, we report a functional characterization of 12 variants located beyond the first two intronic nucleotides using RNAseq in APC, ATM, FH, LZTR1, MSH6, PALB2, RAD51C, and TP53 genes. Based on the analysis of mRNA, we have successfully reclassified 50% of investigated variants. 25% of variants were downgraded to likely benign, whereas 25% were upgraded to likely pathogenic leading to improved clinical management of the patient and the family members. 相似文献
6.
考虑了应用吴方法求解多元有理样条函数的计算问题,将多项式样条函数的维数级数理论推广到带有理因子的有理样条空间,建立了相应的维数公式。 相似文献
7.
Maria Teresa Vietri Giovanna DElia Gemma Caliendo Marianna Resse Amelia Casamassimi Luana Passariello Luisa Albanese Michele Cioffi Anna Maria Molinari 《International journal of molecular sciences》2021,22(7)
Prostate cancer (PCa) is globally the second most diagnosed cancer type and the most common cause of cancer-related deaths in men. Family history of PCa, hereditary breast and ovarian cancer (HBOC) and Lynch syndromes (LS), are among the most important risk factors compared to age, race, ethnicity and environmental factors for PCa development. Hereditary prostate cancer (HPCa) has the highest heritability of any major cancer in men. The proportion of PCa attributable to hereditary factors has been estimated in the range of 5–15%. To date, the genes more consistently associated to HPCa susceptibility include mismatch repair (MMR) genes (MLH1, MSH2, MSH6, and PMS2) and homologous recombination genes (BRCA1/2, ATM, PALB2, CHEK2). Additional genes are also recommended to be integrated into specific research, including HOXB13, BRP1 and NSB1. Importantly, BRCA1/BRCA2 and ATM mutated patients potentially benefit from Poly (ADP-ribose) polymerase PARP inhibitors, through a mechanism of synthetic lethality, causing selective tumor cell cytotoxicity in cell lines. Moreover, the detection of germline alterations in MMR genes has therapeutic implications, as it may help to predict immunotherapy benefits. Here, we discuss the current knowledge of the genetic basis for inherited predisposition to PCa, the potential target therapy, and the role of active surveillance as a management strategy for patients with low-risk PCa. Finally, the current PCa guideline recommendations are reviewed. 相似文献
8.
Kimiyoshi Ichida Yoshihiro Amaya Ken Okamoto Takeshi Nishino 《International journal of molecular sciences》2012,13(11):15475-15495
Xanthine oxidoreductase (XOR) catalyzes the conversion of hypoxanthine to xanthine and xanthine to uric acid with concomitant reduction of either NAD+ or O2. The enzyme is a target of drugs to treat hyperuricemia, gout and reactive oxygen-related diseases. Human diseases associated with genetically determined dysfunction of XOR are termed xanthinuria, because of the excretion of xanthine in urine. Xanthinuria is classified into two subtypes, type I and type II. Type I xanthinuria involves XOR deficiency due to genetic defect of XOR, whereas type II xanthinuria involves dual deficiency of XOR and aldehyde oxidase (AO, a molybdoflavo enzyme similar to XOR) due to genetic defect in the molybdenum cofactor sulfurase. Molybdenum cofactor deficiency is associated with triple deficiency of XOR, AO and sulfite oxidase, due to defective synthesis of molybdopterin, which is a precursor of molybdenum cofactor for all three enzymes. The present review focuses on mutation or chemical modification studies of mammalian XOR, as well as on XOR mutations identified in humans, aimed at understanding the reaction mechanism of XOR and the relevance of mutated XORs as models to estimate the possible side effects of clinical application of XOR inhibitors. 相似文献
9.
The statement and solution algorithm are proposed for the problem on the stress-strain state of a kimberlite body, filling
massif, and enclosing rock during slice chamber mining with filling. The equations of nonlinear hereditary viscoelasticity
are used as the constitutive relations for saliferous rocks.
__________
Translated from Fiziko-Tekhnicheskie Problemy Razrabotki Poleznykh Iskopaemykh, No. 3, pp. 26–37, May–June, 2005. 相似文献
10.
Jan Pitha Martina Huttl Hana Malinska Denisa Miklankova Hana Bartuskova Tomas Hlinka Irena Markova 《International journal of molecular sciences》2022,23(5)
Background: If menopause is really independent risk factor for cardiovascular disease is still under debate. We studied if ovariectomy in the model of insulin resistance causes cardiovascular changes, to what extent are these changes reversible by estradiol substitution and if they are accompanied by changes in other organs and tissues. Methods: Hereditary hypertriglyceridemic female rats were divided into three groups: ovariectomized at 8th week (n = 6), ovariectomized with 17-β estradiol substitution (n = 6), and the sham group (n = 5). The strain of abdominal aorta measured by ultrasound, expression of vascular genes, weight and content of myocardium and also non-cardiac parameters were analyzed. Results: After ovariectomy, the strain of abdominal aorta, expression of nitric oxide synthase in abdominal aorta, relative weight of myocardium and of the left ventricle and circulating interleukin-6 decreased; these changes were reversed by estradiol substitution. Interestingly, the content of triglycerides in myocardium did not change after ovariectomy, but significantly increased after estradiol substitution while adiposity index did not change after ovariectomy, but significantly decreased after estradiol substitution. Conclusion: Vascular and cardiac parameters under study differed in their response to ovariectomy and estradiol substitution. This indicates different effects of ovariectomy and estradiol on different cardiovascular but also extracardiac structures. 相似文献