靶向抗癌药格列卫与其治疗白血病疗效监测

Gleevec是抑制致癌的融合蛋白BCR-ABL的一种分子靶向治疗药物,BCR-ABL是一种与慢性髓细胞性白血病(CML)有关的酪氨酸激酶抑制剂。用Gleevec选择性地抑制BCR-ABL活性在治疗CML中显示出很好的效果,特别是在CML慢性期,因此,监测疗效非常重要。现就Gleevec的研究进展及如何监测其在CML中的疗效作一简单综述。     

光纤荧光传感器衰减寿命的加权对数拟合法

荧光寿命的检测是荧光光学传感器的核心内容，国际上尝试了多种方法来拟合这种理论上为单指数衰减信号的荧光衰减曲线。这些方法包括非线性函数标准拟合方法。即Levenburg-Marquardt方法，以及Prony方法、FFT方法，对数拟合法等等。为了克服在实际应用中发生的信号退化，需要在测量信号衰减寿命的同时测量信号的初始强度。文章介绍了一种加权的对数拟合法，经计算机仿真及实际数据测试均可以得到和Levenburg-Marquardt方法非常接近的结果，且拟合时间大大缩短，测量稳定性大大提高。仿真测试及具体实验测试结果显示了这种方法的有效性。该方法不仅与Levenburg-Marquardt方法的偏差曲线非常相似，而且实验测得的荧光寿命与Levenburg-Marquardt方法偏差在0．2％以内。     

Experimental Research on Erbium-doped Superfluorescent Fiber Source

The effects of the variations in fiber length, fiber mirror reflectance on efficiency and output power are experimentally investigated for erbium-doped double pass backward superfluorescent fiber sources (SFSs). The influence of fiber length on mean wavelength stability (MWS) has also been demonstrated. By incorporating a short section of un-pumped erbium-doped fiber (EDF) at the output port, the pump power dependent on MWS becomes independent of pumped EDF length. This is a novel phenomenon that hasn‘t been reported up to now,and should be helpful to SFS fabrication and theory analysis. By using a fiber Michelson interferometer as spectrum slicing component,a multi-wavelength fiber source (MWFS) with ～20 channels (from 1542nm to 1559nm) is got. The MWFS has a channel spacing of ～0. 8 nm which satisfies ITUstandard. The intensity fluctuation among channels is less than 0.5dB,and the extinction ratio of all channels is above 14dB. This kind of MWFS should be useful to wavelength division multiplexing systems.     

纳米银粒子印刷纳米电路，杀灭微生物

据报道，美国纽约州西部城市布法罗的纳米动力公司开发出可以用喷墨或传统印刷技术直接进行印刷的直径20nm的银粒子，可以广泛地用于各种基体，包括纸张、塑料等易弯曲材料。纳米银还在阻止物质表面的细菌、真菌、有害孢子和其它危险微生物的生长方面显示了卓越潜力，这些物质表面是传染病扩散的主要途径。可以将直径20nm的银粒子混入建筑用漆中，或涂在瓷砖、医疗器械、甚至石膏板表面，减缓或阻止有潜在危险的细菌和真菌的生长。     

磺胺喹啉新衍生物的合成及其应用的研究

由8-氨基喹啉-5-偶氮衍生物与苯磺酰氯或对甲苯磺酰氯反应制得了6种磺胺喹啉偶氮衍生物.产品经红外光谱和元素分析确证.用光度法测定了其中两个试剂的酸离解常数.系统研究了试剂与金属离子的显色反应和荧光反应.发现SPTSQ,NPTSQ和NPBSQ是Cu(Ⅱ)、Co(Ⅱ)、Ni(Ⅱ)、Pd(Ⅱ)、Au(Ⅲ)、Pt(Ⅱ)的灵敏光度试剂,6个衍生物均是Cu(Ⅱ)、Co(Ⅱ)的灵敏荧光试剂,其中MOPBSQ和AAPTSQ还是Pd(Ⅱ)的良好荧光试剂.建立了几个性能优良的光度、荧光和极谱分析新体系.     

一种发出红色荧光的六核配合物[Cu6（pymt）6]

合成了一价铜和2-巯基嘧啶盐的配合物[Cu6（pymt）6]并进行结构分析，该配合物能发出强的红色荧光。其中，一价铜离子的配位环境为变形平面三角形，陪体pymt采用μ3-S2N桥联方式参与配位。     

Study on Effect of Flux on CeMgAl11O19：Tb^3＋ Phosphor

High calcination temperature is an important factor in the preparation process of CeMgAl11O19:Tb^3 . To decrease the temperature, different fluxes (H3BO3, MgF2 and AlF3) were tested in order to compare their influence on the luminescence property and particle size distribution of CeMgAl11O19: Tb^3 . The result shows that when the content of MgF2 is 0.1 mol/mol, the intensity of luminescence can attain a maximum. Furthermore, MgF2 can improve the particle size quality of the phosphor. So MgF2 can take the place of the conventional flux H3BO3 to prepare high quality CeMgAl11O19:Tb^3 phosphor. In addition, the relation between phosphor property and content of AlF3 was also studied. The crystal structure of the phosphor was analyzed by XRD method. The phase composition analysis shows that the reason of decrease of the brightness of CeMgAl11O19:Tb^3 phosphor is the emergence of TbAlO3 and α-Al2O3 during the preparation process.     

3080E3型X射线荧光光谱仪电路故障的诊断及处理

文章通过对3080 E3型X射线荧光光谱仪电子电路故障的诊断及处理,介绍了一般电子电路故障的诊断及处理方法。