Microstructure developed in the surface layer of Ti-6Al-4V alloy after sliding wear in vacuum

Microstructural changes in the surface layer of Ti-6Al-4V alloy after sliding wear in vacuum have been studied by means of scanning and transmission electron microscopy (SEM and TEM). The wear rates of Ti-6Al-4V alloy in vacuum were measured under different sliding velocities and loads. The experimental results showed that a severely deformed layer with a grain size of 50–100 nm and thickness about 70 μm was formed underneath the worn surface. Under the slower sliding velocities, the substructure of the layer had a high dislocation density, while under higher sliding velocities, twins were found to exist in the substructure. A process by which the deformed layer formed has been proposed and the deformation of materials at the contacting spots of the Ti-6Al-4V sample is discussed.     

三聚氰胺氰尿酸盐对锦纶6的抗滴落阻燃改性研究

通过在聚己内酰胺(PA6)切片中加入不同比例的三聚氰胺氰尿酸盐(MCA)或三聚氰胺多聚磷酸盐(MPP)-MCA共混纺丝,改善锦纶6的抗滴落阻燃性.研究发现,加入30%(wt)MCA的PA6仍具有可纺性,且随MCA添加量的增加,极限氧指数(LOI)增加,纤维的物理力学性能下降,阻燃剂的加入使聚合物的热稳定性变差,含有MCA-MPP共混物的纤维阻燃性及物理力学性能均好于单纯含有MCA的纤维.     

一种5.0~9.3 GHz低功耗宽带低噪声放大器设计

针对Wi-Fi 6、Wi-Fi 6E(5 GHz、6 GHz)的低功耗、宽带宽等无线局域网(WLAN)设备需求,基于65 nm CMOS工艺设计了一款两级低功耗宽带低噪声放大器(LNA)。电路第一级采用结合互补共源电路的共源共栅结构,通过电感峰化技术和负反馈技术的运用,提高输入跨导,降低噪声,并拓展带宽和提高增益平坦度。第二级在共漏极缓冲器基础上引入辅助放大结构、电感峰化技术,实现抵消第一级共源管的噪声并拓展带宽。电路采用提出的前向衬底自偏置技术,以降低电路对电源电压的依赖,整体电路实现两路电流复用,从而有效降低了功耗。仿真结果表明,在5~9.3 GHz频带内LNA的S21为17.8±0.1 dB,S11小于-9 dB、S22小于-11.9 dB,噪声系数小于1.34 dB。在0.8 V电压下整体电路功耗为5.3 mW。     

Effects of Combining Biofactors on Bioenergetic Parameters,Aβ Levels and Survival in Alzheimer Model Organisms

Increased amyloid beta (Aβ) levels and mitochondrial dysfunction (MD) in the human brain characterize Alzheimer disease (AD). Folic acid, magnesium and vitamin B6 are essential micro-nutrients that may provide neuroprotection. Bioenergetic parameters and amyloid precursor protein (APP) processing products were investigated in vitro in human neuroblastoma SH-SY5Y-APP695 cells, expressing neuronal APP, and in vivo, in the invertebrate Caenorhabditis elegans (CL2006 & GMC101) expressing muscular APP. Model organisms were incubated with either folic acid and magnesium-orotate (ID63) or folic acid, magnesium-orotate and vitamin B6 (ID64) in different concentrations. ID63 and ID64 reduced Aβ, soluble alpha APP (sAPPα), and lactate levels in SH-SY5Y-APP695 cells. The latter might be explained by enhanced expression of lactate dehydrogenase (LDHA). Micronutrient combinations had no effects on mitochondrial parameters in SH-SY5Y-APP695 cells. ID64 showed a significant life-prolonging effect in C. elegans CL2006. Incubation of GMC101 with ID63 significantly lowered Aβ aggregation. Both combinations significantly reduced paralysis and thus improved the phenotype in GMC101. Thus, the combinations of the tested biofactors are effective in pre-clinical models of AD by interfering with Aβ related pathways and glycolysis.     

Regulation of S100As Expression by Inflammatory Cytokines in Chronic Lymphocytic Leukemia

The calcium-binding proteins S100A4, S100A8, and S100A9 are upregulated in chronic lymphocytic leukemia (CLL), while the S100A9 promotes NF-κB activity during disease progression. The S100-protein family has been involved in several malignancies as mediators of inflammation and proliferation. The hypothesis of our study is that S100A proteins are mediators in signaling pathways associated with inflammation-induced proliferation, such as NF-κB, PI3K/AKT, and JAK/STAT. The mononuclear cells (MNCs) of CLL were treated with proinflammatory IL-6, anti-inflammatory IL-10 cytokines, inhibitors of JAK1/2, NF-κB, and PI3K signaling pathways, to evaluate S100A4, S100A8, S100A9, and S100A12 expression as well as NF-κB activation by qRT-PCR, immunocytochemistry, and immunoblotting. The quantity of S100A4, S100A8, and S100A9 positive cells (p < 0.05) and their protein expression (p < 0.01) were significantly decreased in MNCs of CLL patients compared to healthy controls. The S100A levels were generally increased in CD19⁺ cells compared to MNCs of CLL. The S100A4 gene expression was significantly stimulated (p < 0.05) by the inhibition of the PI3K/AKT signaling pathway in MNCs. IL-6 stimulated S100A4 and S100A8 protein expression, prevented by the NF-κB and JAK1/2 inhibitors. In contrast, IL-10 reduced S100A8, S100A9, and S100A12 protein expressions in MNCs of CLL. Moreover, IL-10 inhibited activation of NF-κB signaling (4-fold, p < 0.05). In conclusion, inflammation stimulated the S100A protein expression mediated via the proliferation-related signaling and balanced by the cytokines in CLL.     

下一代互联网真实地址寻址技术实现及试验情况

随着网络规模的不断扩大和应用方式的多样化,互联网在安全可信方面正面临着挑战.作为可信任下一代互联网的重要基础,研究真实地址寻址技术具有十分重要的意义.本文从体系结构出发,对真实地址寻址结构各个层面的技术实现进行了说明,并介绍了基于CNGI-CERNT2的真实地址寻址试验网.     

HDAC8-Selective Inhibition by PCI-34051 Enhances the Anticancer Effects of ACY-241 in Ovarian Cancer Cells

HDAC6 is overexpressed in ovarian cancer and is known to be correlated with tumorigenesis. Accordingly, ACY-241, a selective HDAC6 inhibitor, is currently under clinical trial and has been tested in combination with various drugs. HDAC8, another member of the HDAC family, has recently gained attention as a novel target for cancer therapy. Here, we evaluated the synergistic anticancer effects of PCI-34051 and ACY-241 in ovarian cancer. Among various ovarian cancer cells, PCI-34051 effectively suppresses cell proliferation in wild-type p53 ovarian cancer cells compared with mutant p53 ovarian cancer cells. In ovarian cancer cells harboring wild-type p53, PCI-34051 in combination with ACY-241 synergistically represses cell proliferation, enhances apoptosis, and suppresses cell migration. The expression of pro-apoptotic proteins is synergistically upregulated, whereas the expressions of anti-apoptotic proteins and metastasis-associated proteins are significantly downregulated in combination treatment. Furthermore, the level of acetyl-p53 at K381 is synergistically upregulated upon combination treatment. Overall, co-inhibition of HDAC6 and HDAC8 through selective inhibitors synergistically suppresses cancer cell proliferation and metastasis in p53 wild-type ovarian cancer cells. These results suggest a novel approach to treating ovarian cancer patients and the therapeutic potential in developing HDAC6/8 dual inhibitors.     

DHCPv6中的中继代理在IPv6路由器中的实现

随着IPv6下的动态主机配置协议DHCPv6的制定,各大设备和服务供应商已经开始支持DHCPv6的功能。本文对DHCPv6的特性、原理及工作过程做了介绍;设计实现了DHCPv6Relay功能,并详细介绍了中继代理对报文的处理过程。DHCPv6Relay已经在某公司的高端路由器SR88系列上投入了商用。     

在移动IP网络中实现Anycast服务的一种通信模型

提出了一种建立在移动IP网络中的Anycast通信模型,深入分析和讨论了该模型的可行性及其有效性,并论证此模型可以支持在移动IP网络中建设大规模的Anycast组。