Preliminary results of post-irradiation examinations on LiSoR-2 test section

Liquid-solid reaction under irradiation (LiSoR) experiments are aimed at understanding the effects of liquid lead-bismuth eutectic (LBE) corrosion and embrittlement under irradiation on structural materials, which is one of the key items of the materials R&D for the future accelerator-driven system (ADS). The LiSoR setup is basically a LBE loop with a test section irradiated with 72 MeV protons. The second irradiation was conducted for about 34 h and terminated after a leakage of LBE was detected. Post-irradiation examinations (PIE) are being performed on both the tube and tensile specimen in the test section. Optical microscopy, scanning electron microscopy, transmission electron microscopy and microhardness tests have been completed. The results show that a crack formed in the irradiation zone of the tube. In the material in the irradiation zones of both the tube and the tensile specimen dislocation cell structure is well developed, which indicates heavy deformation due to thermal fatigue. The crack should start at the inner surface and propagate to the outer surface. The fracture surfaces of the crack are dominated by a brittle cleavage fracture mode. However, on the surfaces of the tensile specimen, no microcracks are observed.     

SPS烧结M42粉末冶金高速钢的显微组织与性能

采用放电等离子烧结技术(SPS)制备了M42粉末冶金高速钢,研究了SPS烧结M42粉末冶金高速钢及其热处理后的显微组织与性能。结果表明:与普通粉末冶金高速钢相比,SPS烧结制备的M42粉末冶金高速钢显微组织均匀、晶粒细小、无碳化物偏析。经过在1180℃×5min×550℃×1h的热处理后,硬度比普通粉末冶金高速钢提高1～2HRC。     

One of the Primary Functions of Tissue-Resident Pluripotent Pericytes Cells May Be to Regulate Normal Organ Growth and Maturation: Implications for Attempts to Repair Tissues Later in Life

Adult mesenchymal stem cells were reported more than 30 years ago. Since then, their potential to repair and regenerate damaged or diseased tissues has been studied intensively in both preclinical models and human trials. Most of the need for such tissue repair/regeneration is in older populations, so much of the effort has been performed with autologous cells in older patients. However, success has been difficult to achieve. In the literature, it has been noted that such progenitor cells from younger individuals often behave with more vigorous activity and are functionally enhanced compared to those from older individuals or animals. In addition, cells with the characteristics of mesenchymal stem cells or pluripotent mesenchymal regulatory cells exist in nearly all tissues and organs as pericytes since fetal life. Such evidence raises the possibility that one of the primary roles of these organ-specific cells is to regulate organ growth and maturation, and then subsequently play a role in the maintenance of organ integrity. This review will discuss the evidence to support this concept and the implications of such a concept regarding the use of these progenitor cells for the repair and regeneration of tissues damaged by injury or disease later in life. For the latter, it may be necessary to return the organ-specific progenitor cells to the functional state that contributed to their effectiveness during growth and maturation rather than attempting to use them after alterations imposed during the aging process have been established and their function compromised.     

Theragnostic Efficacy of K18 Response in Alcohol Use Disorder with Clinically Significant Fibrosis Using Gut-Liver Axis

(1) Background: Fibrosis in early-stage alcohol-associated liver disease (ALD) is commonly under-diagnosed in routine clinical practice. This study characterized the liver-injury and cell death response in alcohol use disorder (AUD) patients with ALD who also exhibited fibrosis and assessed the efficacy of standard of care (SOC) treatment in the improvement in liver injury. (2) Methods: Forty-eight heavy-drinking AUD patients aged 21–65 yrs. without clinical manifestations of liver injury were grouped by Fibrosis-4 (FIB-4) score, as negative (Gr.1 < 1.45, n = 21) or positive (Gr.2 ≥ 1.45, n = 27). Patients received 2-weeks (2 w) inpatient SOC. Data on demographics, drinking patterns, liver-injury, immune markers, and liver cell death (K18s) markers were analyzed at baseline (BL) and after 2 w SOC. (3) Results: Lifetime drinking (LTDH, yrs.) and acute heavy drinking (Heavy Drinking Days Past 90 Days [HDD90]) markers were significantly higher in Gr.2 vs. Gr.1. BL ALT, AST, AST:ALT and K18M65 were considerably higher in Gr.2. Dysregulated gut dysfunction and elevated immune activity were evident in Gr.2 characterized by TNF-α, IL-8 and LPS levels. After SOC, Gr.2 showed improvement in AST, ALT, AST/ALT ratio; and in the K18M65, K18M30 and K18M65/M30 ratio vs. Gr.1. The true positivity of BL IL-8 response to predict the improvement in K18M65 to normal levels among Gr.2 patients against those who did not have improvement after 2 w SOC was very high (AUROC = 0.830, p = 0.042). (4) Conclusions: Gut dysfunction, elevated cytokine response and necrotic liver cell death were elevated in AUD patients with early-stage ALD. K18 showed promise as a predictive theragnostic factor to differentiate among the AUD patients with early-stage ALD and baseline fibrosis who had improvement in liver injury against those who did not, by the levels of baseline IL-8.     

一种针对图像模糊的无参考质量评价指标

在成像模型的基础上,分析了图像模糊的原因,提出了一种为图像构造参考图像的方法,进而将结构相似度(SSIM)评价方法引入到无参考图像质量评价中,提出一种无参考结构清晰度(NRSS)的新的无参考图像质量评价方法,将其用于对模糊图像的质量评价。该方法通过低通滤波器来构造参考图像,通过计算原始图像与参考图像的结构相似度值来评价原始图像质量,很好地结合了成像系统的数学模型和结构相似度评价方法的优势,实验结果表明无参考结构清晰度评价指标能够给出和主观评价方法以及其余有参考评价方法一致的结果。     

Genome-Wide Analysis of the Peptidase M24 Superfamily in Triticum aestivum Demonstrates That TaM24-9 Is Involved in Abiotic Stress Response

The peptidase M24 (Metallopeptidase 24, M24) superfamily is essential for plant growth, stress response, and pathogen defense. At present, there are few systematic reports on the identification and classification of members of the peptidase M24 proteins superfamily in wheat. In this work, we identified 53 putative candidate TaM24 genes. According to the protein sequences characteristics, these members can be roughly divided into three subfamilies: I, II, III. Most TaM24 genes are complex with multiple exons, and the motifs are relatively conserved in each sub-group. Through chromosome mapping analysis, we found that the 53 genes were unevenly distributed on 19 wheat chromosomes (except 3A and 3D), of which 68% were in triads. Analysis of gene duplication events showed that 62% of TaM24 genes in wheat came from fragment duplication events, and there were no tandem duplication events to amplify genes. Analysis of the promoter sequences of TaM24 genes revealed that cis-acting elements were rich in response elements to drought, osmotic stress, ABA, and MeJA. We also studied the expression of TaM24 in wheat tissues at developmental stages and abiotic stress. Then we selected TaM24-9 as the target for further analysis. The results showed that TaM24-9 genes strengthened the drought and salt tolerance of plants. Overall, our analysis showed that members of the peptidase M24 genes may participate in the abiotic stress response and provided potential gene resources for improving wheat resistance.     

电机转速和转子位置数字测量方法的研究

电机转速和转子位置的测量在电机交直流调速控制系统中占有重要的位置,为提高测量的精度和避免噪声影响,多采用数字式测量方法.基于常规的M/T法,提出了电机转速和转子位置测量的综合M/T法,该方法是利用测量电路对光电编码器信号进行预处理,以确定采样信号脉冲与码盘信号脉冲之间的相对位置,并将这个相对位置表示为含有小数的码盘脉冲个数,由此不仅可以测量出电机在采样时刻的转速,同时还可以测量出该时刻电机的转子位置.与常规的M/T法相比,该方法提高了测量的精度,扩展了M/T法的应用范围.     

Twelve-Nitrogen-Atom Cyclic Structure Stabilized by 3d-Element Atoms: Quantum Chemical Modeling

Using various versions of density functional theory (DFT), DFT M06/TZVP, DFT B3PW91/TZVP, DFT OPBE/TZVP, and, partially, the MP2 method, the possibility of the existence of 3d-element (M) compounds with nitrogen having unusual M: nitrogen ratio 1:12, unknown for these elements at the present, was shown. Structural parameter data were presented. It was shown that all MN4 groupings have tetragonal-pyramidal structure. It was noted that the bond lengths formed by nitrogen atoms and an M atom were equal to each other only in the case of M = Ti, V, Cr and Co, whereas for other Ms, they were slightly different; moreover, the bond angles formed by nitrogen atoms and an M atom were equal to 90.0°, or practically did not differ from this value. Thermodynamic parameters, NBO analysis data and HOMO/LUMO images for this compound were also presented. Good agreement between the calculated data obtained using the above three quantum chemical methods was also noted.     

三槽丝锥中径的测量

本文介绍在没有专用量具、量仪的条件下,在双面啮合综合检查仪上用比较测量法,测出三槽丝锥的1/2M值,然后计算出中径d2的方法.