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101.
Sunan Wang Kelly A. Meckling Massimo F. Marcone Yukio Kakuda Rong Tsao 《Food research international (Ottawa, Ont.)》2011,44(9):2545-2554
The search for therapeutic anticancer agents from plant-based foods became the work of numerous researchers when epidemiological studies showed a relationship between the low incidence of cancer and the intake of plant-based foods. These researchers were especially interested in plant-based foods with high antioxidant capacities because of the important role antioxidants have been postulated to play in the prevention and treatment of certain cancers. However, at present there is no conclusive proof that high antioxidant activity is a good indicator of high anticancer activity. This poses a challenge for researchers to directly test this hypothesis and resolve the debate. This review summarized the data on both sides of the debate. 相似文献
102.
Vladimíra Tome?kováMária Reháková Gabriela Moj?išováJozef Magura Tommy WadstenKatarína Zelenáková 《Microporous and mesoporous materials》2012,147(1):59-67
Natural zeolite of the clinoptilolite type (CT, particle size up to 200 μm) and its modified forms with different content (0.06-5%) of pharmaceutically active compounds (type of flavonoids): quercetin (Q) and quercetin dihydrate (QD) have been investigated by thermal analyses TG, DTA and DTG, FTIR spectroscopy, fluorescence spectroscopy, X-ray powder diffractometry, determination of the surface areas and the pore volumes by low-temperature adsorption of nitrogen and atomic force microscopy. The analyses checked the presence of Q or QD in modified zeolitic products (CTQ and CTQD).Natural zeolite of the clinoptilolite type and their modified forms CTQ and CTQD with low content (0.06% and 1%) of Q and QD have been used for the study of their anticancer activity. Carcinoma cell lines Jurkat, CEM, HeLa, MCF7, A549 and MDA were treated with various amounts of natural clinoptilolite and their modified forms CTQ and CTQD. The water content of the channel system influences the cytotoxicity of zeolite. The results of the study of pure CT thermally activated at two different temperatures 110 and 400 °C confirmed the better cytotoxicity of CT activated at 110 °C (CT110) with higher content of water in comparison with CT activated at 400 °C (CT400). Clinoptilolite modified with quercetin dihydrate (CTQD) has shown better cytotoxicity compared with clinoptilolite modified with quercetin (CTQ). 相似文献
103.
Gaik Ming KhooMorten Rahr Clausen Hanne Lindhard PedersenErik Larsen 《Food chemistry》2012,132(3):1214-1220
Eleven blackcurrant cultivars grown with pesticide (PT) and without pesticide treatment (PF) were evaluated to compare the differences in plant growth and physical condition, total anthocyanin content, ascorbic acid content, total antioxidant capacity, effect on prostaglandin E2 (PGE2) production and anticancer cell proliferation activities. Results showed that the yield and growth of PT blackcurrants were higher. However, PF blackcurrants contained a higher amount of ascorbic acid, and displayed an increased inhibition against cancer cells compared to PT blackcurrants, indicating that PF blackcurrants have an increased potential to deliver health-promoting benefit for consumers. Significant differences were observed between blackcurrant cultivars in relation to plant growth and physical condition, total anthocyanin content and PGE2 assay, highlighting the importance of cultivar selection. 相似文献
104.
Shochu distillation remnants (SDR) are by-products in the manufacturing process of the Japanese liquor Shochu and include various useful organic compounds derived from the fermentation of grains. We have obtained valuable powder (PSDR) from freeze-dried SDR by the treatment with ethanol. In this study, we examined the anticancer effects of barley-, rice-, and sweet potato-PSDR against HepG2 and HuH-7 cells of human hepatocellular carcinoma (HCC) in?vitro. All PSDR inhibited the growth of both these HCC cells through the induction of apoptosis. Especially, barley-PSDR was the most effective for the growth inhibition and apoptosis induction of HCC cells of all PSDR. We next examined the apoptotic mechanisms induced by barley-PSDR. Decrease in mitochondrial membrane potential and release of cytochrome c from mitochondria were observed in HCC cells after the treatment with barley-PSDR. Furthermore, barley-PSDR induced the nuclear translocation of apoptosis-inducing factor (AIF) from mitochondria, while it did not significantly affect the activities of caspase-3, -8, and -9. The results suggested that barley-PSDR induced apoptosis against HCC cells via the caspase-independent mitochondrial pathway. The findings in this study suggest that PSDR has the possibility of therapeutic and/or preventive agents of HCC. 相似文献
105.
Although leaves of Curcuma mangga and Curcuma longa are used in food preparations, the bioactive components in it are not known. In this study, antioxidant, antiinflammatory and anticancer activities of leave extracts and its isolates were investigated using established bioassay procedures in our laboratory. The leaf extracts of both plants gave similar bioassay and chromatographic profiles. The methanolic and water extracts of C. mangga (CMM and CMW) and C. longa (CLM and CLW), at 100 μg/mL, inhibited lipid peroxidation (LPO) by 78%, 63%, 81% and 43%, cyclooxygenase enzymes COX-1 by 55%, 33%, 43% and 24% and COX-2 by 65%, 55%, 77% and 69%, respectively. At same concentration, CMM, CMW, CLM and CLW showed growth inhibition of human tumour cell lines by 0-46%. Therefore, a bioassay-guided isolation of water and methanolic extracts of C. longa was carried out and afforded nine isolates. At 25 μg/mL, these compounds inhibited LPO by 11-87%, COX-1 and -2 enzymes by 0-35% and 0-82% and growth of human tumour cells by 0-36%, respectively. 相似文献
106.
杂环基缩胺硫脲的合成及其抗癌活性的研究Ⅱ 总被引:3,自引:0,他引:3
研究了结构为Ⅰ的杂环基缩胺硫脲的合成及其抗癌活性。肼、二硫化碳与碘甲烷反应,生成Ⅱ,Ⅱ与2-乙既噻唑反应生成Ⅲ,产率84%。Ⅲ与Ⅰ-取代哌嗪反应生成Ⅰ,产率58%。由NMR谱分析,Ⅲ为两种异构体的混合物,其E/Z约为5/2。Ⅰ经体外筛选表明具有明显的抗癌活性。 相似文献
107.
The methanolic extract of Garciniamangostana fruit pericarp was partitioned into butanol and water fractions in this work. Three major phenolics were purified and identified as P1 [1,3,6,7-tetrahydroxy-2,8-(3-methyl-2-butenyl) xanthone], P2 [1,3,6-trihydroxy-7-methoxy-2,8-(3-methyl-2-butenyl) xanthone] and P3 (epicatechin). Strong antioxidant activities were detected for P1–P3. In vitro cell proliferation trials indicated that P1 and P3 exhibited good immunomodulatory activities when 7.5 μg/ml was used. Furthermore, P1 and P3 showed good cytotoxicities against human breast cancer cells (MCF-7) and human colon cancer cells (LOVO). P1 exhibited the maximal cytotoxicity of 73.06% against MCF-7 cells and of 46.27% against LOVO cells when 62.5 μg/ml was used. The cytotoxicities of P1, P2, P3 and paclitaxel against normal embryonic lung fibroblast cells (HELF) were in a decreasing order: paclitaxel > P3 > P1 > P2. These results suggested that P1 and P3 could be used as a potential anticancer agent. 相似文献
108.
110.
Mohamed Hosny Manal Fawzy Ola M. El-Borady Alaa El Din Mahmoud 《Advanced Powder Technology》2021,32(7):2268-2279
In this research, we adopt an ecofriendly and sustainable approach to compare the potentiality and efficiency of Phragmites australis aqueous extracts of two different organs to fabricate gold nanoparticles (AuNPs). The aqueous extracts of plant roots and rhizome were used as alternative reducing agents to conventional chemicals. Various Characterization techniques were used; UV–Vis spectroscopy, Zeta potential, Fourier Transform Infrared Spectroscopy (FT-IR), X-ray diffraction (XRD), Selected Area Electron Diffraction (SAED), Energy Dispersive X-ray Spectroscopy (EDX), High Resolution Transmission Electron Microscopy (HRTEM) equipped with elemental mapping in order to confirm the formation of zero-valent AuNPs, X-ray photoelectron spectroscopy (XPS). Our results demonstrated that both extracts of Phragmites australis are good candidates for the green-synthesis of AuNPs. Zeta potential was used to confirm the stability of AuNPs. The cytotoxic capacities of both AuNPs samples were validated using MTT assay which proved the inhibition of the growth and proliferation of human lung cancer cells (A549 cell line). Antioxidant potentialities were >10%. The phytosynthesized AuNPs exhibited high capacity in removing methylene blue and methyl orange dyes within just one min. This research offers an alternative solution to manage the accumulated unwanted biomass of a widely distributed aquatic macrophyte in aquatic ecosystems. 相似文献