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71.
Giuseppina Emanuela Grieco Noemi Brusco Giada Licata Daniela Fignani Caterina Formichi Laura Nigi Guido Sebastiani Francesco Dotta 《International journal of molecular sciences》2021,22(2)
Diabetes mellitus is a group of heterogeneous metabolic disorders characterized by chronic hyperglycaemia mainly due to pancreatic β cell death and/or dysfunction, caused by several types of stress such as glucotoxicity, lipotoxicity and inflammation. Different patho-physiological mechanisms driving β cell response to these stresses are tightly regulated by microRNAs (miRNAs), a class of negative regulators of gene expression, involved in pathogenic mechanisms occurring in diabetes and in its complications. In this review, we aim to shed light on the most important miRNAs regulating the maintenance and the robustness of β cell identity, as well as on those miRNAs involved in the pathogenesis of the two main forms of diabetes mellitus, i.e., type 1 and type 2 diabetes. Additionally, we acknowledge that the understanding of miRNAs-regulated molecular mechanisms is fundamental in order to develop specific and effective strategies based on miRNAs as therapeutic targets, employing innovative molecules. 相似文献
72.
本文通过模拟地下管道阴极保护的现场,测定了地下的杂散电流及其对阴极保护效果的影响,并对相关问题进行了分析。 相似文献
73.
本文从热处理工艺设计入手,阐述了工艺设计的衡量标准以及环保的重要性,论述了热处理工艺设计的特点和工程设计人员的任务。 相似文献
74.
Thermal sprayed aluminum and zinc provide long-term (> 20 years to first maintenance) corrosion control coatings. However,
this application is usually more expensive than painting or galvanizing if thermal spraying (metallizing) is not integrated
into the design and fabrication phases of new construction and repair projects. Aluminum and zinc metallized coatings are
tough enough to withstand fabrication, transportation, and assembly operations. The improved capabilities and productivity
of metallizing equipment for aluminum and zinc spraying are a major factor in their current cost competitiveness. The net
result is that the cost difference between metallizing, paint, and galvanizing is getting closer every day. Even though the
initial application cost of metallizing may be higher, the life cycle cost (LCC) and average equivalent annual costs (AEAC)
are lower than paint coating systems. Metallizing LCCs, when properly engineered into the construction schedule, are equal
to or less than paint coating LCCs. This article summarizes some metallizing considerations for installing improved corrosion
control coating systems in new construction and in maintenance and repair of infrastructure.
Editor’s Note: The following constants have been used to convert between English and Metric dimensions: 1ft2-0.0929 m2; 1lb/ft2-4.89 kg/m2; 1 mil=0.025mm.
Presented at the 5th National Thermal Spray Conference (NTSC-93), Infrastructure Maintenance and Repair Session, 10 June 1993,
Anaheim, CA. 相似文献
75.
Andrea Kunova Luca Palazzolo Fabio Forlani Giorgia Catinella Loana Musso Paolo Cortesi Ivano Eberini Andrea Pinto Sabrina Dallavalle 《International journal of molecular sciences》2021,22(7)
The increasing emergence of fungicide-resistant pathogens requires urgent solutions for crop disease management. Here, we describe a structural investigation of new fungicides obtained by combining strobilurin and succinate dehydrogenase inhibitor pharmacophores. We identified compounds endowed with very good activity against wild-type Pyricularia oryzae, combined in some cases with promising activity against strobilurin-resistant strains. The first three-dimensional model of P. oryzae cytochrome bc1 complex containing azoxystrobin as a ligand was developed. The model was validated with a set of commercially available strobilurins, and it well explains both the resistance mechanism to strobilurins mediated by the mutation G143A and the activity of metyltetraprole against strobilurin-resistant strains. The obtained results shed light on the key recognition determinants of strobilurin-like derivatives in the cytochrome bc1 active site and will guide the further rational design of new fungicides able to overcome resistance caused by G143A mutation in the rice blast pathogen. 相似文献
76.
Serena Montalbano Francesca Degola Jennifer Bartoli Franco Bisceglie Annamaria Buschini Mauro Carcelli Donatella Feretti Serena Galati Laura Marchi Nicol Orsoni Giorgio Pelosi Marianna Pioli Francesco M. Restivo Dominga Rogolino Mirco Scaccaglia Olga Serra Giorgio Spadola Gaia C. V. Viola Ilaria Zerbini Claudia Zani 《International journal of molecular sciences》2021,22(9)
The control of the fungal contamination on crops is considered a priority by the sanitary authorities of an increasing number of countries, and this is also due to the fact that the geographic areas interested in mycotoxin outbreaks are widening. Among the different pre- and post-harvest strategies that may be applied to prevent fungal and/or aflatoxin contamination, fungicides still play a prominent role; however, despite of countless efforts, to date the problem of food and feed contamination remains unsolved, since the essential factors that affect aflatoxins production are various and hardly to handle as a whole. In this scenario, the exploitation of bioactive natural sources to obtain new agents presenting novel mechanisms of action may represent a successful strategy to minimize, at the same time, aflatoxin contamination and the use of toxic pesticides. The Aflatox® Project was aimed at the development of new-generation inhibitors of aflatoxigenic Aspergillus spp. proliferation and toxin production, through the modification of naturally occurring molecules: a panel of 177 compounds, belonging to the thiosemicarbazones class, have been synthesized and screened for their antifungal and anti-aflatoxigenic potential. The most effective compounds, selected as the best candidates as aflatoxin containment agents, were also evaluated in terms of cytotoxicity, genotoxicity and epi-genotoxicity to exclude potential harmful effect on the human health, the plants on which fungi grow and the whole ecosystem. 相似文献
77.
Junpeng Xiong Weili Shao Ling Wang Chen Cui Yurui Jin Hongqin Yu Pengju Han Yanfei Gao Fan Liu Qingqing Ni Jianxin He 《大分子材料与工程》2021,306(11):2100371
Recently, because of the outbreak of COVID-19, the demand for various types of filter elements in protective materials has increased globally. Furthermore, new requirements for the filtration performance of PM2.5 liquid (oil) particles have been put forward. In this work, Superhydrophobic and superoleophobic composite nanofibers with excellent filtration capacity for oil and salt particles are developed through the modification of polyacrylonitrile (PAN) by fluoro-polyurethane (FPU) doping. The results show that the PAN/FPU composite nanofibers doped with 9 wt% FPU has a uniform fiber morphology with a diameter of 240 ± 30 nm. Compared to the pure PAN nanofibers, the water-based contact angle of PAN/FPU increases from 90 ± 5° to 151 ± 5°, and the oil-based contact angle increases from 58 ± 2° to 152 ± 3°. Importantly, at a high flow rate of 95 L min−1, the filtration efficiency of the PAN/FPU nanofiber membrane for 0.3 µm oil particles increases from 92 ± 1% to 99.2 ± 0.1%. After cyclic loading, the filtration efficiency of 0.3 µm oil particles remains above 98%. Meanwhile, the filtration efficiency for 0.3 µm salt particles remains at 98.23 ± 0.1%. The PAN/FPU nanofiber membrane developed in this work is effective in applications and has good market prospects as a protective filtration material. 相似文献
78.
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80.
在总结我国环保产业研究与发展现状的基础上 ,指出我国环保产业的发展必须得到理论研究的指导 ,并对有关问题进行了深入地探讨。根据我国加入WTO后的环保产业现状 ,预测、分析了将在我国环保产业形成投资热点的几个领域 相似文献