Senescence Marker Protein 30 (SMP30): A Novel Pan-Species Diagnostic Marker for the Histopathological Diagnosis of Breast Cancer in Humans and Animals

Senescence marker protein 30 (SMP30) is a cell survival factor playing an important role in vitamin C synthesis and antiapoptosis. Moreover, its cytoprotective role suggests a possibility to be related to cancer cell survival. Mammary carcinoma is a common cancer in both humans and animals. Because of its histopathological diversity, especially in the early stage, histopathological diagnosis may be complicated; therefore, a diagnostic marker is helpful for confirmation. The present study analyzed the expression pattern of SMP30 in mammary carcinoma in humans, dogs, and cats. Immunohistochemistry, immunofluorescence, and western blot analysis were used to investigate SMP30 expression patterns. The expression was specifically observed in neoplastic glandular epithelial cells. The expression increased with the malignancy of glandular epithelial cells with a highly proliferative status. However, SMP30 expression was low in normal mammary gland tissues or well-differentiated adenoma tissues. The patterns were consistently reproduced in canine primary mammary carcinoma cells and MCF-7 and MDA-MB-231 human carcinoma cell lines. This study provides useful information to understand SMP30 expression in various stages of mammary carcinoma and to suggest its utility as a pan-species diagnostic marker, thereby helping to establish strategies for diagnosing mammary carcinoma in several species.     

淬火工艺及Nb元素对30MnB5钢原奥氏体晶粒度的影响

利用光学显微镜(OM),研究了淬火工艺及Nb元素对30MnB5钢的原奥氏体晶粒度的影响。结果表明:含Nb的30MnB5钢在淬火温度860~920 ℃,保温时间不超过60 min时,原奥氏体晶粒度具有良好的稳定性;当淬火温度达到950 ℃时,保温时间超过30 min后,原奥氏体晶粒尺寸随着保温时间增长逐渐变大;因此,淬火温度低于950 ℃时,Nb元素对30MnB5钢热处理过程中原奥氏体晶粒生长具有抑制作用;当淬火温度达到1000 ℃时,Nb元素仅在30 min以内对原奥氏体晶粒生长有轻微抑制作用,当淬火保温时间超过60 min时,Nb元素完全失去对原奥氏体晶粒生长的抑制作用。     

Cu-30Ni合金机械冲击表面纳米化组织和性能(英文)

采用大应力塑性变形(机械冲击)技术对Cu-30Ni合金表面进行纳米化处理。利用原子力显微镜技术、纳米压痕试样、显微硬度测量、电化学分析和电子功函数等手段分别测试原始样品、大应力塑性变形纳米化处理样品的晶粒尺寸、力学性能、腐蚀性能。结果表明,与原始样品相比,大应力塑性变形纳米化处理样品的表面晶粒尺寸达到40nm;力学性能显著改善。电化学测试表明,表面纳米化提高了合金的耐腐蚀性能,耐腐蚀性能变化与电子功函数变化一致。机械冲击工艺技术能够使Cu-30Ni合金表面纳米化,从而提高了表面力学性能和耐腐蚀性能。     

低压转子钢30Cr2Ni4MoV扭转镦粗数值模拟

由于扭转镦粗较传统平砧镦粗对锻件施加了扭矩,从而降低了下压载荷,并且使得锻件变形更加均匀。利用DEFORM-3D软件对30Cr2Ni4MoV低压转子钢进行扭转镦粗模拟试验,同时优化工艺参数,证明扭转镦粗锻造法是一种有效改善锻件质量的工艺方法。     

A panoramic view of Li7P3S11 solid electrolytes synthesis,structural aspects and practical challenges for all-solid-state lithium batteries

The development of an inorganic electrochemical stable solid-state electrolyte is essentially responsible for future state-of-the-art all-solid-state lithium batteries (ASSLBs). Because of their advantages in safety, working temperature, high energy density, and packaging, ASSLBs can develop an ideal energy storage system for modern electric vehicles (EVs). A solid electrolyte (SE) model must have an economical synthesis approach, exhibit electrochemical and chemical stability, high ionic conductivity, and low interfacial resistance. Owing to its highest conductivity of 17 mS·cm^-1, and deformability, the sulfide-based Li₇P₃S₁₁ solid electrolyte is a promising contender for the high-performance bulk type of ASSLBs. Herein, we present a current glimpse of the progress of synthetic procedures, structural aspects, and ionic conductivity improvement strategies. Structural elucidation and mechanistic approaches have been extensively discussed by using various characterization techniques. The chemical stability of Li₇P₃S₁₁ could be enhanced via oxide doping, and hard and soft acid/base (HSAB) concepts are also discussed. The issues to be undertaken for designing the ideal solid electrolytes, interfacial challenges, and high energy density have been discoursed. This review aims to provide a bird's eye view of the recent development of Li₇P₃S₁₁-based solid-state electrolyte applications and explore the strategies for designing new solid electrolytes with a target-oriented approach to enhance the efficiency of high energy density all-solid-state lithium batteries.     

新型高能叠氮硝胺发射药高压燃烧稳定性研究

为了研究高能发射药膛内燃烧规律,通过半溶剂法制备了一种火药力高达1240J/g的新型高能叠氮硝胺发射药(ADR),采用高压密闭爆发器和30mm高压模拟试验装置,分别研究了不同温度下ADR发射药定容高压燃烧性能和装填密度、温度以及石墨光泽处理对ADR发射药膛内高压燃烧稳定性的影响。结果表明,不同温度条件下(-40、20和50℃)ADR发射药静态及动态燃烧性能稳定性良好,燃烧过程无异常;随着温度的增加,ADR发射药点火性能提高,增加了膛内燃烧稳定性;装填密度0.48~0.64g/cm³范围内,随着装填密度的增加,ADR发射药膛内压力波强度逐渐增加,但增长幅度减小;对发射药进行石墨光泽处理,增加了ADR发射药起始缓燃效果,使不同温度下膛内压力波强度明显降低;与RGD7发射药相比,ADR发射药火药力较高,爆温较低,发射装药膛内高压燃烧稳定性相当,在高膛压环境中应用前景较好。     

Effect of Natural and Synthetic Surfactant on the Rheology of Light Crude Oil

Comparative effectiveness of natural surfactant extracted from Sapindus mukorossi in laboratory and commercial surfactant Brij 30 was determined. Light crude oil was collected from ONGC, Gujarat, India. Its pour point and viscosity decreased significantly after adding surfactants. Wax crystal structure and crystal size distribution was analyzed using cross polarized light microscope and dynamic light scattering techniques. There was remarkable reduction in radius of wax crystals after addition of both the surfactants. Microscopic studies showed significant change in size and structure of wax crystals favoring reduction in viscosity. The possible mechanism behind improvement of flow properties was also analyzed through FTIR studies.     

SD10W／30汽油机油实用性配方研究

以HVIW150和HVI150为基础油,加入4．5％复合添加剂,研制出SD10W／30汽油机油,调制的油品质质量符合GB11121－1995中SD级油标准,剂量小,成本低。     

冷124—14—30井区储预测与圈闭评价

立足于地质、地震、测井等多学科互相配合,利用先进的技术软件,进行高精度合成地震记录制作、三维地震精细构造解释、地层层序划分对比、储层反演等综合地质研究,揭示了冷家油田冷124-14-30井区储层及圈闭特征目的层层位为下第三系沙河街组三段,构造复杂,发育北东和北西两组断裂;发育陡坡型扇三角洲沉积体系,可划分为6种沉积微相;储层平均孔隙度为24.5%,渗透率1463×10-3μm2,属于中高孔、高渗储层;油藏类型为岩性-构造油藏,油水分布受构造、沉积微相等多种因素控制,油气主要分布在构造高部位.通过综合评价,新发现4个圈闭,部署滚动井3口,增加石油地质储量347×104t.     

较高铜含量30MnSi盘条的实际应用

介绍 30MnSi盘条的成分、性能 ,对直径为 8.0～ 12mm不同含铜量的 30MnSi盘条进行力学性能测试和对比 ,并对用户的成材率和实用情况进行跟踪 ,结果显示 :当该钢号的盘条铜的质量分数低于 0 .30 %时不影响正常使用。