便携式瓦斯报警仪充电控制电路的研究与设计

针对目前便携式瓦斯报警仪在使用中存在放电时间短的问题,从软件上提出了一种针对镍氢电池充电的新方法。该方法提高了检测镍氢电池充电曲线下降沿的可靠性,延长了便携式瓦斯报警仪的单次放电时间。     

Optical Disks as a Basis of Modern Paperless Data Processing

Potentialities of the methods of information processing, distribution, and storage are analyzed. Directions are defined in which optical information media characteristics can be improved. Possibility of using optical media for a long-term storage of digital information is considered.     

无线局域网研究

介绍了WLAN概念,以及WLAN与有线局域网相比具有的优点,同时给出了WLAN的组网方式和所遵循的协议规范以及在安全性方面如何实现,以实例体现了WLAN在公司办公室中的具体应用。     

Performance comparison of 100Base-T fast ethernet and 100VG-AnyLAN

There are two competing technologies for 100 Mbps Ethernet, namely IEEE 802.3u 100Base-T Fast Ethernet and IEEE 802.12 100VG-AnyLAN. The former technology is based on the same medium access control protocol as the popular IEEE 802.3 CSMA/CD network, while the later is based on a new demand priority protocol. Contrary to common belief, a test conducted recently by Newman and Levy using commercially available adaptor cards and hubs showed that 100Base-T networks outperformed 100VG-AnyLAN networks with similar configurations by a significant margin. From the analytical models developed, we found that the anomaly is due to the larger-than-expected overheads incurred by the 100VG-AnyLAN hub in polling every station in the network in a round robin manner.     

落锤试验测定船板的无塑性转变温度

无塑性转变温度是安全设计的重要参量，广泛应用于材料研究和产品质量控制过程。利用落锤试验方法，测定了AH36级船板的无塑性转变温度为-25℃，并对试验结果进行了评定。结果表明，落锤试验方法简单，试验数据重复性好，当船板的服役温度高于NDTT时，基本保证船板不会发生脆断。     

基于并行设计思想的薄壳屋面造型研究

以自由曲面薄壳屋面概念设计方案为对象，基于并行设计思想提出了一套可供参考的评价最优建筑造型方案的方法。以整体结构的应变能最小作为自由曲面薄壳屋面优化选型的目标函数，将方案的形状优化和拓扑优化目标函数相统一，从而对初始造型进行优化设计，确定了符合结构整体应变能最小的最优建筑造型方案，并通过具体数值算例证明了所选方案的合理性。     

放射敏感性启动子调控CD基因/5-FC自杀系统慢病毒载体的构建及125I诱导表达的研究

合成了含8个CArG元件的放射敏感性启动子E8,将其连接于胞嘧啶脱氨酶（Cytosine Deaminase, CD）基因及GFP报告基因上游,构建了重组慢病毒载体pGC-FU-E8-codA-GFP。与慢病毒包装系统共转染293T细胞包装重组慢病毒颗粒E8-codA-GFP LV,研究重组慢病毒感染EJ细胞在不同剂量¹²⁵I的电离辐射下绿色荧光表达情况及其将5-FC转化为5-FU的能力。结果显示：构建的含有E8启动子及CD基因的重组慢病毒载体,包装的重组慢病毒滴度为2×10⁸TU/mL;经¹²⁵I照射的重组慢病毒感染EJ细胞均可观察到绿色荧光,其细胞上清液均可检测到5-FC转化成的5-FU紫外峰,其中55.5 kBq及74.0 kBq ¹²⁵I照射的细胞组绿色荧光明显,148 kBq ¹²⁵I照射的细胞组,其5-FU紫外峰最为明显。以上结果表明：本工作所构建的放射敏感性启动子调控CD基因/5-FC自杀系统重组慢病毒载体具有电离辐射调控作用,可在¹²⁵I的电离辐射作用下诱导下游基因表达,为放射性核素¹²⁵I联合CD基因/5-FC自杀系统对肿瘤细胞的治疗作用研究提供了实验基础。     

基于改进对比散度的GRBM语音识别

对比散度作为训练受限波尔兹曼机模型的主流技术之一,在实验训练中具有较好的测试效果。通过结合指数平均数指标算法和并行回火的思想,提出一种改进对比散度的训练算法,包括模型参数的更新和样本数据的采样,并将改进后的训练算法应用于高斯伯努利受限玻尔兹曼机( GRBM)中训练语音识别模型参数。在TI-Digits数字语音训练和数字测试数据库上的实验结果表明,采用改进的对比散度训练的GRBM明显优于传统的模型训练算法,语音识别率能够达到80%左右,最高提升7%左右,而且应用改进算法训练的其他GRBM对比模型的语音识别率也都有所提高,具有较好的识别性能。     

Near-Complete Remission of Glioblastoma in a Patient Treated with an Allogenic Dendritic Cell-Based Vaccine: The Role of Tumor-Specific CD4+T-Cell Cytokine Secretion Pattern in Predicting Response and Recurrence

Immunotherapy has brought hope to the fight against glioblastoma, but its efficacy remains unclear. We present the case of CST, a 25-year-old female patient with a large right-hemisphere glioblastoma treated with a dendritic–tumor cell fusion vaccine. CST showed a near-complete tumor response, with a marked improvement in her functional status and simultaneous increases in tumor-specific CD8+ and CD4+ T cells. Two months before recurrence, the frequency of tumor-specific T cells decreased, while that of IL-17 and CD4+ T cells increased. CST passed away 15 months after enrollment. In this illustrative case, the tumor-specific CD4+ T-cell numbers and phenotype behaved as treatment efficacy biomarkers, highlighting the key role of the latter in glioblastoma immunotherapy.