Shrinkage-based regularization tests for high-dimensional data with application to gene set analysis

Traditional multivariate tests such as Hotelling’s test or Wilk’s test are designed for classical problems, where the number of observations is much larger than the dimension of the variables. For high-dimensional data, however, this assumption cannot be met any longer. In this article, we consider testing problems in high-dimensional MANOVA where the number of variables exceeds the sample size. To overcome the challenges with high dimensionality, we propose a new approach called a shrinkage-based regularization test, which is suitable for a variety of data structures including the one-sample problem and one-way MANOVA. Our approach uses a ridge regularization to overcome the singularity of the sample covariance matrix and applies a soft-thresholding technique to reduce random noise and improve the testing power. An appealing property of this approach is its ability to select relevant variables that provide evidence against the hypothesis. We compare the performance of our approach with some competing approaches via real microarray data and simulation studies. The results illustrate that the proposed statistics maintains relatively high power in detecting a wide family of alternatives.     

分布实时系统中的点到点通信

本文给出了一种由点到点互连网络连接的实时系统通信方法,分析了通道建立过程,消息调度算法,缓冲预留方案,以及消息传递时间的计算模型,可提供确定性的消息传递延迟。     

在VB中用ADO实现广域网中的远程数据库访问

由于通道质量问题,广域网中的数据传输极易发生中断。本文在通道不稳定的条件下,实现了在广域网中用VB6.0中基于OLEDB技术的ADO访问远程数据库,在工程实践中取得较好效果。     

光纤通道适配器基本原理及其实现的研究

本文在分析光纤通道协议结构的基础上,研究了光纤通道主机适配器的体系结构和电路原理,以ISP2200A为核心芯片探讨了其电路实现和作业流程。所获得的结论对于光纤通道接口的设计和构建SAN系统具有普遍的意义。     

基于VSAT的移动指挥系统

通过一个实例介绍基于VSAT的移动指挥系统的设计,阐述了系统的基本结构单元与数据接口,最后,指出系统建设的注意要点。     

第三代移动通信系统中的信道分配技术

移动通信系统发展至今信道分配技术一直都是热门话题,一个好的信道分配算法可以在特定的服务等级下(包括链路质量,新呼叫阻塞概率,切换失败概率)产生很高的频谱利用率。本文注重结合第三代移动通信系统对现有的信道分配技术进行综述并分析其优劣。     

Experimental study of diffusion-based extraction from a cell suspension

A recently proposed application of microfluidics is the post-thaw processing of biological cells. Numerical simulations suggest that diffusion-based extraction of the cryoprotective agent dimethyl sulfoxide (DMSO) from blood cells is viable and more efficient than centrifugation, the conventional method of DMSO removal. In order to validate the theoretical model used in these simulations, a prototype was built and the flow of two parallel streams, a suspension of Jurkat cells containing DMSO and a wash stream that contained neither cells nor DMSO, was characterized experimentally. DMSO transport in a rectangular channel (depth 500 μm, width 25 mm and overall length 125 mm) was studied as a function of three dimensionless parameters: depth ratio of the streams, cell volume fraction in the cell solution, and the Peclet number (Pe) based on channel depth, average flow rate and the diffusion coefficient for DMSO in water. In our studies, values of Pe ranged from O(10³) to O(10⁴). Laminar flow was ensured by keeping the Reynolds number between O(1) and O(10). Experimental results based on visual and quantitative data demonstrate conclusively that a microfluidic device can effectively remove DMSO from liquid and cell laden streams without compromising cell recovery. Also, flow conditions in the microfluidic device appear to have no adverse effect on cell viability at the outlet. Further, the results demonstrate that we can predict the amount of DMSO removed from a given device with the theoretical model mentioned previously.     

A hybrid channel assignment strategy to QoS support of video-streaming over multi-channel ad hoc networks

Currently multi-channel multi-interface ad hoc networks (multi-channel ad hoc networks) have received amount of interest, especially under the context of real-time traffics, such as video applications. Channel assignment is one of the key challenges in multi-channel ad hoc networks. In this paper, based on a representative hybrid channel assignment strategy named as HMCP, a statistic link load based hybrid channel assignment strategy, SLL-HCA, is presented to obtain a better channel assignment metric than that in HMCP. SLL-HCA is based on the HMCP protocol and adopts the statistic link load metric to ensure load balancing in a two-hop neighborhood, and to prevent both the hidden node problem and the exposed node problem. In addition, an enhanced strategy, VE-SLL-HCA, by setting harsher channel assignment conditions and reserving lower interference of routing path for video-streaming traffic than other non-video traffic, is proposed to improve the QoS support of video-streaming over multi-channel ad hoc networks. Simulation results show that SLL-HCA achieves better throughput performance than HMCP in the presence of background traffic including CBR traffic or VBR traffic; and, the PSNR QoS metric for video-streaming is enhanced when using VE-SLL-HCA compared with SLL-HCA and HMCP, which confirms the validity of the proposed strategy for video-streaming traffics. Moreover, the simulation results also indicate that non-video traffic unlikely suffers an unacceptable performance in terms of throughput.     

An unsupervised data projection that preserves the cluster structure

In this paper we propose a new unsupervised dimensionality reduction algorithm that looks for a projection that optimally preserves the clustering data structure of the original space. Formally we attempt to find a projection that maximizes the mutual information between data points and clusters in the projected space. In order to compute the mutual information, we neither assume the data are given in terms of distributions nor impose any parametric model on the within-cluster distribution. Instead, we utilize a non-parametric estimation of the average cluster entropies and search for a linear projection and a clustering that maximizes the estimated mutual information between the projected data points and the clusters. The improved performance is demonstrated on both synthetic and real world examples.     

Preliminary Assessment and Rating of Stream Channel Stability near Bridges

The primary cause of bridge failure in the United States is scour and channel instability around the bridge foundations. The ability to assess channel stability in the vicinity of bridges is needed to alert engineers to possible unstable conditions at the bridge foundations, to design stable road crossings, and to mitigate against erosion at those structures. This information is valuable for stream stabilization projects as well, particularly for cases where the reach to be restored includes a bridge. However, a systematic methodology for rapidly assessing channel stability that is applicable at bridges located in the various regions of the country does not currently exist. In this study, an assessment method for the preliminary documentation and rating of channel stability near bridges was developed, based on prior stability assessment methods as well as observations at bridges in 13 physiographic regions of the continental United States. This method provides an assessment of channel stability conditions as they affect bridge foundations. It is intended for a quick assessment of conditions for the purpose of documenting conditions at bridges and for judging whether more extensive geomorphic studies or complete hydraulic and sediment transport analyses are needed to assess the potential for adverse conditions developing at a particular bridge in the future.