Altered Elemental Distribution in Male Rat Brain Tissue as a Predictor of Glioblastoma Multiforme Growth—Studies Using SR-XRF Microscopy

Glioblastoma multiforme (GBM) is a particularly malignant primary brain tumor. Despite enormous advances in the surgical treatment of cancer, radio- and chemotherapy, the average survival of patients suffering from this cancer does not usually exceed several months. For obvious ethical reasons, the search and testing of the new drugs and therapies of GBM cannot be carried out on humans, and for this purpose, animal models of the disease are most often used. However, to assess the efficacy and safety of the therapy basing on these models, a deep knowledge of the pathological changes associated with tumor development in the animal brain is necessary. Therefore, as part of our study, the synchrotron radiation-based X-ray fluorescence microscopy was applied for multi-elemental micro-imaging of the rat brain in which glioblastoma develops. Elemental changes occurring in animals after the implantation of two human glioma cell lines as well as the cells taken directly from a patient suffering from GBM were compared. Both the extent and intensity of elemental changes strongly correlated with the regions of glioma growth. The obtained results showed that the observation of elemental anomalies accompanying tumor development within an animal’s brain might facilitate our understanding of the pathogenesis and progress of GBM and also determine potential biomarkers of its extension. The tumors appearing in a rat’s brain were characterized by an increased accumulation of Fe and Se, whilst the tissue directly surrounding the tumor presented a higher accumulation of Cu. Furthermore, the results of the study allow us to consider Se as a potential elemental marker of GBM progression.     

The conductance and magnetoresistance effect in a periodically magnetically modulated nanostructure

In this paper, we theoretically investigate the conductance and the magnetoresistance effect in a periodically magnetically modulated two-dimensional electron gas. It is shown that there exists a significant conductance difference for electrons through the parallel and antiparallel magnetization configurations, which leads to a considerable magnetoresistance effect. It is also shown that the conductance and the magnetoresistance effect depend on both the temperature and the number of the periodic magnetic barriers.     

4,6-二异丙基二苯并噻吩衍生物化学稳定性的理论研究

利用Gaussian98软件包,采用密度泛函理论(DFT)中的杂化密度泛函B3LYP方法和使用3-21G基组对4,6-二异丙基二苯并噻吩等9种衍生物进行了计算机模拟优化和频率分析,考察了4,6-二异丙基二苯并噻吩及其衍生物的部分原子电子密度,部分键长、键角和二面角以及非键相互作用。计算机模拟结果显示取代基的电子效应不是影响噻吩类加氢脱硫过程的关键因素,而取代基的空间效应以及非键相互作用则会直接影响深度加氢脱硫的效果。     

Waterloo Packer: Selling Slaughter

In 1941, the Rath Packing Company of Waterloo, Iowa published a book titled Waterloo Packer: The Story of the Rath Packing Company to celebrate its fiftieth anniversary in the meatpacking industry. Modelled on Life magazine, Waterloo Packer co-opted the photoessay format to commercial ends. Examining archival documentation and looking at other American industrial publications, this article illuminates Waterloo Packer’s conception by executives of the Rath Company and consultants from advertising agency Young and Rubicam; and it contextualises Waterloo Packer as the most innovative of a series of ‘industrial biographies’ produced in the USA at midcentury. Through close reading of Waterloo Packer as phototext, this article demonstrates how the Rath Packing Company deployed photographic imagery to present a controlled and sanitised vision of industrial-scale slaughter.     

Natural Photographs: Optograms and the Fiction of Captured Vision

An optogram is an image fixed on the retina by a biological, photochemical process. In the late nineteenth century, it was widely believed that optograms could be excised from dead bodies to procure their final visions. Optograms were most frequently compared to photographs, so that the retina of the eye was likened to the sensitive plate in a camera. Just as photography became capable of superseding human vision in the 1870s, optograms discursively came to light as latent photographs, making photography the original for preconscious sight. These historical inversions of primacy challenge our conceptions of the relation between nature and culture in photography, with the cultural invention preceding the natural discovery of optography. This article examines how an incidental, speculative, and ultimately forgotten discovery in the physical sciences was deployed rhetorically to reinforce personal or disciplinary beliefs about what photography was and what it could do, in realms ranging from physiological laboratories to science fiction, from police departments to courtrooms. Analysis of optographic discourse indicates that the true value of photography in the late nineteenth century was not primarily in the photograph’s relation to its indexical referent, but in the possibility that it might grant access to seeing as another living being.     

实现从EWB到Protel98的真正接口

介绍了如何实现由EWB中的电路图到Prote198中印刷电路板图的自动布线。     

WIN98下并行口数据采集的编程与实现

WIN9x操作系统采用 Vx D方式来管理对于硬件的访问 ,程序的硬件操作能否与该机制相适应 ,对于软件的可靠性有着重要意义。主要介绍了 WIN9x环境下 Vx D(虚拟设备驱动程序 )及其优点 ,并与其它几种数据采集方法做了比较。分析了在 WIN95/98下 ,通过并行口读取数据采集卡数据的 Vx D开发方法 ,以及有关调试软件 (Soft/Ice)的使用。文中给出了一个程序实例 ,表明该方法是可行的。     

Windows95/98中的注册表及应用

介绍了Ｗｉｎ９５／９８注册表的有关知识及应用。