基于激光扫描的船舶超载超吃水自动监测系统

近年来,内河干线航道超载、超吃水现象较为严重,船舶搁浅、碰撞等水上交通事故时有发生.而目前相应的治理手段单一,尽管相关部门投入了巨大的人力、物力、财力,但效果也并不理想.设计并实现了一套基于激光扫描和视频分析的船舶超载超吃水自动监测系统,并在镇江市地方海事局辖区水域实现了应用.结果表明,实际应用中系统在测量精度、实时性等方面表现优异,能够满足海事部门的日常监管需求.     

基于DSC控制的移相全桥DC/DC变换器

数字控制由于高集成度带来的低成本、设计沿继性、控制灵活等优点而应用逐渐广泛,电力电子应用逐渐朝着高频化方向发展,这也对高频开关电源的数字控制提出了要求。利用Freescale新型号数字信号控制器(DigitalSingnalController,DSC)MC56F8323的高性能特性,完成了基于DSC的带同步整流的高频软开关移相全桥变换器的数字控制,描述了DSC产生软件移相控制策略,并给出了详细的数字控制系统设计和软件结构设计,最后用一台500W实验样机验证了数字控制所带来的优良的系统性能。     

大变形对钨合金材料扫描断口及力学性能的影响

研究了高强度钨合金材料大变形量锻造后的扫描断口,并结合力学性能变化规律分析了大变形对材料组织和性能的影响。结果表明随着变形量增大断口上钨颗粒尺寸减小并呈多边化趋势,断裂方式则呈现钨颗粒解理断裂逐渐增多的特点,这些变化有利于钨合金材料的强化     

聚酯的热性能分析

使用DSC差示扫描量热仪对聚酯进行了热性能分析测试,分析了样品量和样品状态对聚酯热性能分析测试的影响,样品量的大小影响曲线图形,从而影响结晶度的准确分析判断。同等试样量时,整粒样品的熔点测定值略高于剪碎样品的熔点测定值。     

邻苯二甲酸二烯丙基酯树脂固化特性的研究

运用示差扫描量热(DSC)法研究了邻苯二甲酸二烯丙基酯(DAP)树脂的固化反应历程。讨论了引发剂对DAP固化特性的影响,并由DSC曲线得到了DAP树脂的固化工艺和动力学参数。通过固化度、FT-IR的测试对DAP树脂在中温条件下的固化情况进行了研究。结果表明:在过氧化二异丙苯(DCP)固化体系中引入BPO可以使DAP树脂在更低温度下引发固化;在BPO、DCP用量均为2%的条件下,确定了体系的凝胶温度、固化温度、后处理温度分别为:100.5℃,124.3℃,137.8℃,表观活化能为129.3 kJ/mol,反应级数为0.950。固化度、FTIR的测试结果表明:DAP树脂在中温条件下可以固化得较完全。     

杂萘联苯聚醚砜酮/环氧树脂共混体系固化反应动力学

采用热熔法制备了杂萘联苯聚醚砜酮(PPESK)/环氧树脂(E-51)共混物,利用差示扫描量热仪(DSC)对共混物的固化反应动力学进行了研究。借助Ozawa和Kissinger等方法确定了PPESK增韧E-51体系的固化动力学参数,包括反应的表观活化能E,指前因子A和反应级数n;结果表明,采用新型高性能热塑性树脂PPESK增韧环氧树脂不仅在工艺上具有可行性,而且PPESK的加入降低了固化反应的表观活化能,促进了固化反应的进行。     

透明聚丙烯EP2X32G结晶性能研究

通过差示扫描量热仪和广角X光衍射等分析方法,研究EP2X32G及其基料的结晶性能。结果表明,EP2X32G及其基料中存在α和γ两种晶型。     

SARS-CoV-2 Infection Dysregulates Cilia and Basal Cell Homeostasis in the Respiratory Epithelium of Hamsters

Similar to many other respiratory viruses, SARS-CoV-2 targets the ciliated cells of the respiratory epithelium and compromises mucociliary clearance, thereby facilitating spread to the lungs and paving the way for secondary infections. A detailed understanding of mechanism involved in ciliary loss and subsequent regeneration is crucial to assess the possible long-term consequences of COVID-19. The aim of this study was to characterize the sequence of histological and ultrastructural changes observed in the ciliated epithelium during and after SARS-CoV-2 infection in the golden Syrian hamster model. We show that acute infection induces a severe, transient loss of cilia, which is, at least in part, caused by cilia internalization. Internalized cilia colocalize with membrane invaginations, facilitating virus entry into the cell. Infection also results in a progressive decline in cells expressing the regulator of ciliogenesis FOXJ1, which persists beyond virus clearance and the termination of inflammatory changes. Ciliary loss triggers the mobilization of p73⁺ and CK14⁺ basal cells, which ceases after regeneration of the cilia. Although ciliation is restored after two weeks despite the lack of FOXJ1, an increased frequency of cilia with ultrastructural alterations indicative of secondary ciliary dyskinesia is observed. In summary, the work provides new insights into SARS-CoV-2 pathogenesis and expands our understanding of virally induced damage to defense mechanisms in the conducting airways.     

The Use of Molecular Dynamics Simulation Method to Quantitatively Evaluate the Affinity between HBV Antigen T Cell Epitope Peptides and HLA-A Molecules

Chronic hepatitis B virus (HBV), a potentially life-threatening liver disease, makes people vulnerable to serious diseases such as cancer. T lymphocytes play a crucial role in clearing HBV virus, while the pathway depends on the strong binding of T cell epitope peptide and HLA. However, the experimental identification of HLA-restricted HBV antigenic peptides is extremely time-consuming. In this study, we provide a novel prediction strategy based on structure to assess the affinity between the HBV antigenic peptide and HLA molecule. We used residue scanning, peptide docking and molecular dynamics methods to obtain the molecular docking model of HBV peptide and HLA, and then adopted the MM-GBSA method to calculate the binding affinity of the HBV peptide–HLA complex. Overall, we collected 59 structures of HLA-A from Protein Data Bank, and finally obtained 352 numerical affinity results to figure out the optimal bind choice between the HLA-A molecules and 45 HBV T cell epitope peptides. The results were highly consistent with the qualitative affinity level determined by the competitive peptide binding assay, which confirmed that our affinity prediction process based on an HLA structure is accurate and also proved that the homologous modeling strategy for HLA-A molecules in this study was reliable. Hence, our work highlights an effective way by which to predict and screen for HLA-peptide binding that would improve the treatment of HBV infection.     

P(MMA/EA)/PEG-TPE半互穿网络聚合物的合成

为提高聚甲基丙烯酸甲酯/聚乙二醇聚氨酯(PMMA/PEG-TPE)半互穿网络聚合物的相容性,探索了在PEG-TPE中将甲基丙烯酸甲酯(MMA)与丙烯酸乙酯(EA)共聚形成P(MMA/EA)/PEG-TPE半互穿网络聚合物(S-IPN).红外光谱和核磁共振氢谱分析表明丙烯酸酯基本反应完全,PEG-TPE的单体转化率达到89%; 动态热机械分析(DMA)显示P(MMA/EA)/PEG-TPE的玻璃化转变温度峰较同组成比例的PMMA/PEG-TPE内移,甚至在组成比为10/90,30/70的体系中形成了单一的玻璃化转变峰,且扫描电镜(SEM)中表面形貌也变得较柔顺,表明体系的相容性和互穿程度进一步提高.