基因营养素-核酸在固体饮料中的强化探讨

利用基因营养素-核酸作为强化剂添加在固体饮料中，中老年人通过补充核酸可以养育和修复基因，达到防病治病、延缓衰老、防治心脑血管疾病和糖尿病等目的。本文以基因营养素-核酸作为强化剂来生产固体饮料，就其原料、配方、工艺流程、治病机理、有效成分、组织结构、功效作用、吸收性、安全性、可行性等方面进行了详尽的介绍和探讨。     

Methodology for uncertainty calculation of net total cooling effect estimation for rating room air conditioners and packaged terminal air conditioners

This article presents the general procedure for uncertainty calculation of net total cooling effect estimation for rating room air conditioners and packaged terminal air conditioners, by means of measurements carried out in a test bench specially designed for this purpose. The uncertainty analysis presented in this work looks for establishing a confidence degree or certainty of experimental results. It is particularly important considering that international standards related to this type of analysis are too ambiguous when treating this subject. The uncertainty analysis is on the other hand an indispensable requirement to international standard ISO 17025 [ISO, 2005. International Standard. 17025. General Requirement to Test and Calibration Laboratories Competences. International Organization for Standardization, Geneva.], which must be applied to obtain the required quality levels according to the Word Trade Organization WTO.     

Efficacy of chlorfenapyr against Tribolium castaneum and Tribolium confusum (Coleoptera: Tenebrionidae) adults exposed on concrete, vinyl tile, and plywood surfaces

The insecticidal pyrrole chlorfenapyr was applied to concrete, vinyl tile, and plywood surfaces, at an application rate of 1.1 g AI m⁻². Adult Tribolium castaneum (Herbst), the red flour beetle, and adult Tribolium confusum (Du Val), the confused flour beetle, were exposed for 2 and 4 h, removed, and held without food for 7 d post-exposure. All beetles survived the initial exposures, but survival of both species decreased during the 7-d holding period, with T. confusum being the more susceptible species. Survival was generally lower on concrete than on tile or plywood, and was greatly reduced on all three surfaces after 4 h of exposure compared to 2 h. Survival of T. castaneum after 2 h of exposure on concrete, tile, and plywood was 2.5±2.5%, 25.5±15.4%, and 40.0±7.1%, respectively, after 7 d. In contrast, all T. confusum exposed on concrete and tile were dead after 4 and 5 d, respectively, while survival on plywood after 7 d was 20.0±16.8%. After 4 h of exposure, all T. castaneum and T. confusum exposed on concrete and tile were dead after 2–4 d post-exposure, while survival on plywood after 7 d was 41.5±6.4% and 0 for each species, respectively. Non-linear and linear regressions were fit to the data for both species. Results show exposure to chlorfenapyr is effective against T. castaneum and T. confusum, but efficacy will vary depending on the surface substrate.     

利培酮联合抗抑郁药物治疗抑郁症对照研究的 Meta 分析

目的: 评价利培酮联合抗抑郁药物与抗抑郁药物单一治疗抑郁症的有效性与安全性的差异。方法: 应用循证医学方法对符合标准的10项研究进行分析,评价利培酮联合抗抑郁药物与抗抑郁药物单一治疗抑郁症的疗效、效应大小、痊愈率以及副作用的差异。结果: 同质性检验:(1)有效性:χ²=7.26,d_f=9(P>0.05);(2)安全性:χ²=3.41,d_f=2(P>0.05)。综合检验:研究组与对照组在第1、2、4、6、8周末的综合检验分别为Z₁=14.19(P<0.01)、Z₂=14.00(P<0.01)、Z₄=17.40(P<0.01)、Z₆=12.10(P<0.01)、Z₈=5.94(P<0.01)。效应大小:无论是研究组还是对照组,在第1、2、4、6、8周末与治疗前进行比较的治疗效应大多数达到0.5以上;研究组与对照组干预处理效应的差异效应在不同时段的差异效应都大于0.8。有效性比较:应用固定效应模型或随机效应模型显示研究组所有时段痊愈率、显效率均非常显著高于对照组,而无效率低于对照组(8周末除外)。副作用:两组之间的副作用差异没有显著性(Z=0.20~1.15,P>0.05)。结论: 小剂量利培酮联合抗抑郁药物治疗抑郁症是一种良好的方法,可能特别适宜于难治性抑郁症。     

Modified Therapeutic Antibodies: Improving Efficacy

The prosperity of the biotherapeutics market reflects the feasibility and effectiveness of therapeutic antibodies for the treatment of cancers, inflammatory disorders, and refractory infections. As drawbacks emerge in clinical trials and practice, such as impeded binding, reduced effector functions, and frequent adverse reactions, modifications of therapeutic antibodies are unprecedently burgeoning in research and development (R&D). These modifications include: ① modified glycosylation; ② fragment of crystallizable domain (Fc) amino acid alterations; ③ cross-isotype or cross-subclass exchanges; ④ antibody–drug conjugates (ADCs); ⑤ single chain of variable region fragment (scFv) for chimeric antigen receptor T (CAR-T) cells; and ⑥ bispecific antibodies (bsAbs) in order to promote binding affinity, half-life in circulation, effectiveness toward target cells and, ultimately, to achieve overall improved efficacy. While many achievements have been made around the world in the past decades, China has been playing an active role in this realm, with its great demand for biotherapeutics with R&D potential. This review recapitulates the international progress that has been achieved with modified therapeutic antibodies, and then focuses on that of China in an independent section.     

全液压履带深孔钻车在任楼煤矿瓦斯钻孔施工中的应用

针对煤矿井下瓦斯抽采钻孔布孔密集,成孔速度快,钻机搬迁频繁等特点,任楼煤矿根据煤层赋存特征等地质条件,引进一台CMS1-6200/80型煤矿用全液压履带式深孔钻车,总结出本煤层顺层钻孔施工工艺。     

Efficacy of layer grain treatment with thiamethoxam against adults of Rhyzopertha dominica (F.) and Sitophilus oryzae (L.)

The insecticidal effect of the neonicotinoid insecticide thiamethoxam, applied in layers of wheat, was studied in laboratory experiments, for the control of the lesser grain borer, Rhyzopertha dominica (F.) and the rice weevil Sitophilus oryzae (L.). In general, the increase of the size of the treated layer of wheat increased parental morality and decreased progeny production for both species. However, progeny production could not be totally avoided, even when the entire grain quantity was treated. Parental morality was lower for R. dominica than for S. oryzae, but the reverse was observed for progeny production for all treatments. Insect placement drastically affected thiamethoxam efficacy, since morality was generally higher when insects were forced to move downwards from the upper layer, as compared with insects that had been placed in the bottom part of the wheat column. Our study shows that thiamethoxam can reduce insect populations in partially treated wheat, at concentrations that are comparable with other, currently registered grain protectants.     

办公建筑室内垂直照度对视觉功效的影响评价

办公建筑是企事业单位人员从事各 类业务活动的重要场所。办公建筑的室内光 环境质量将直接影响人员的视觉功效和视力 健康,对提高办公场所的人居环境健康具 有重要意义。本文通过28名被试者对安菲莫 夫表读取完成时间和正确率的数据分析,结 合主观问卷调查反馈数据,结果发现：视觉 功效与垂直照度具有密切相关性;垂直照度 在300-600 lx区段内,21—40岁的人的舒适 度较高;不同年龄段对最佳垂直照度的需求 不同,性别对舒适度影响较小。本文对提升 办公场所室内光环境质量,优化办公照明设 计,改善办公场所人居环境,具有重要的指 导价值,同时将提高学者对垂直照度的关注 度,对未来照明建筑一体化概念的提出具有 重要意义。