阿托伐他汀钙联合普罗布考治疗冠心病合并高脂血症疗效观察

目的观察分析联合阿托伐他汀钙与普罗布考治疗冠心病合并高脂血症的临床疗效。方法将符合标准的冠心病合并高脂血症患者76例随机分为对照组38例和实验组38例,对照组口服阿托伐他汀钙20 mg/d,1次/d;观察组在此基础上加服普罗布考500mg/d,2次/d。2组均连续服药8周。治疗前后对2组患者的TC、TG、LDC-L水平进行检测。结果治疗后2组间血脂指标TC、TG、LDC-L间差异具有统计学意义（P〈0.05）。观察组与对照组完成治疗后总有效率相比,差异具有统计学意义（P〈0.05）,2组均未见明显不良反应。结论联合阿托伐他汀钙与普罗布考联合治疗冠心病合并高脂血症临床效果优于单用阿托伐他汀钙,值得推广采用。     

Efficacy of isoflavones in relieving vasomotor menopausal symptoms – A systematic review

This review assessed the efficacy of isoflavone supplements to reduce vasomotor symptoms in menopausal women by reviewing all published randomized controlled trials. Systematic literature searches were carried out in 70 databases. Randomized and placebo controlled studies were included if they investigated the treatment of isoflavone supplements derived from soy or red clover on vasomotor symptoms in peri‐ or postmenopausal women for at least 12 wks. Data were analyzed concerning outcome and methodological quality of the study. Twenty‐three trials met the inclusion criteria, thereof 17 investigated soy isoflavones and 6 red clover isoflavones. Without exception, selected trials examining the effect of red clover isoflavones were already assessed in several meta‐analyses and were therefore excluded from this evaluation. As the soy isoflavone studies were very heterogeneous concerning interventions and outcome measures, meta‐analysis could not be performed and trials were systematically assessed in a structured approach. Included soy isoflavone studies had numerous quality deficiencies and did not consistently show a reduction of flushes after treatment with soy isoflavones. Therefore, there is no conclusive evidence, but only some indication of a benefit of soy isoflavones on hot flush frequency or severity.     

北京天然光总照度变化趋势分析

基于北京连续54年太阳辐射数据,结合中国辐射光当量模型,获取北京天然光年总照度值和月总照度值。应用Mann—Kendall检验方法分析北京天然光年和月总照度值年际变化趋势,结果表明：北京天然光年总照度基本变化趋势为明显减少,且在1977年突变发生后其下降趋势明显增加;各月月总照度值基本年际变化趋势为明显减少,其中7月月总照度值下降幅度最大。11月月总照度值下降幅度最小;除5月在1967年发生突变外,其它月份的突变均发生在1975—1981年之间;各月天然光月总照度值年际变化在突变前为不明显波动变化趋势,突变后均为明显增加的下降趋势。云量及由大气污染所产生的气溶胶光学厚度是造成北京年与月总照度值持续下降的重要因素。     

5CrMnMo锻模失效分析与失效防止

介绍了5CrMnMo钢锻模的失效形式,以及防止失效的措施。     

Luminous efficacy of daylight under different sky conditions

Dalighting is recognised as an important and useful strategy in terms of energy-efficient building design in hot climates. However, daylighting is always accompanied by unwanted solar heat gain, particularly during the cooling season. To achieve and evaluate daylighting design, solar radiation and outdoor illuminance data are needed. In 1991, a measuring station was installed at the City University of Hong Kong to measure global and diffuse solar radiation and outdoor illuminance. The measured data are analysed, and empirical models to determine luminous efficacy under different sky conditions are developed and presented. Implications for energy efficiency in building designs are discussed.     

A186C型梳棉机安装附加分梳件的研究

介绍了A186C型梳棉机附加分梳件的齿形与结构、测试与分析、使用与维护等情况 ,提出梳棉机不同部位安装附加分梳件有其各自的作用 :刺辊预分梳板有效提高棉束分离度 ,锡林后固定盖板对棉束进行预梳理 ,而锡林前固定盖板则是对梳理区的纤维层进行补充梳理 ,改善棉网内在质量。指出梳棉机安装附加分梳件是增加梳理度的一项十分重要的技术措施     

Accelerated versus standard corneal collagen cross-linking in pediatric keratoconus patients: 24 months follow-up results

Purpose

To compare the 24 month visual, refractive, topographic and aberrometric results of the accelerated and standard corneal collagen cross-linking (CXL) in pediatric keratoconus patients.

Trap catches of stored-product insects before and after heat treatment in a pilot feed mill

The pilot feed mill at Kansas State University was heated to temperatures of 50°C for 28–35 h during August 4–6, 1999 using natural gas heaters to kill stored-product insects. A three-parameter nonlinear regression model satisfactorily described temperature profiles on each of the four mill floors and was useful in showing differences among floors in the number of hours taken to reach 50°C and hours above 50°C. Pitfall traps with food and pheromone lures and sticky traps with pheromone lures were used to sample adults of beetles and moths, respectively, between July 8 and December 1, 1999 to evaluate heat treatment effectiveness. A total of 32 insect species representing 26 families in seven orders were captured in traps. Immediately after heat treatment, there was 95% reduction in total beetle captures in pitfall traps and 99% reduction in moth captures in sticky traps. Trap captures of the almond moth, Cadra cautella (Walker) and cigarette beetle, Lasioderma serricorne (L.) were significantly reduced and remained low after heat treatment. However, trap captures of the flat grain beetle, Cryptolestes pusillus (Schöenherr), Indianmeal moth, Plodia interpunctella (Hübner), and red flour beetle, Tribolium castaneum (Herbst) increased gradually after heat treatment, especially on the 1st and 4th floors. Our results indicated that traps are valuable tools for gauging the degree and duration of insect suppression obtained by heat treatment. In addition to trapping, visual inspection of the mill areas and absolute sampling of ingredients, products and spillage should be undertaken, so that areas of incipient insect reinfestation can be identified and potential problems rectified or averted.     

Efficacy and Safety of Triazavirin Therapy for Coronavirus Disease 2019: A Pilot Randomized Controlled Trial

No therapeutics have been proven effective yet for the treatment of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To assess the efficacy and safety of Triazavirin therapy for COVID-19, we conducted a randomized, double-blinded controlled trial involving hospitalized adult patients with COVID-19. Participants were enrolled from ten sites, and were randomized into two arms of the study with a ratio of 1:1. Patients were treated with Triazavirin 250 mg versus a placebo three or four times a day for 7 d. The primary outcome was set as the time to clinical improvement, defined as normalization of body temperature, respiratory rate, oxygen saturation, cough, and absorption of pulmonary infection by chest computed tomography (CT) until 28 d after randomization. Secondary outcomes included individual components of the primary outcome, the mean time and proportion of inflammatory absorption in the lung, and the conversion rate to a repeated negative SARS-CoV-2 nucleic acid test of throat swab sampling. Concomitant therapeutic treatments, adverse events, and serious adverse events were recorded. Our study was halted after the recruitment of 52 patients, since the number of new infections in the participating hospitals decreased greatly. We randomized 52 patients for treatment with Triazavirin (n = 26) or a placebo (n = 26). We found no differences in the time to clinical improvement (median, 7 d versus 12 d; risk ratio (RR), 2.0; 95% confidence interval (CI), 0.7–5.6; p = 0.2), with clinical improvement occurring in ten patients in the Triazavirin group and six patients in the placebo group (38.5% versus 23.1%; RR, 2.1; 95% CI, 0.6–7.0; p = 0.2). All components of the primary outcome normalized within 28 d, with the exception of absorption of pulmonary infection (Triazavirin 50.0%, placebo 26.1%). Patients in the Triazavirin group used less frequent concomitant therapies for respiratory, cardiac, renal, hepatic, or coagulation supports. Although no statistically significant evidence was found to indicate that Triazavirin benefits COVID-19 patients, our observations indicated possible benefits from its use to treat COVID-19 due to its antiviral effects. Further study is required for confirmation.     

联合氯法齐明方案治疗耐多药肺结核的临床研究

目的: 探讨氯法齐明联合其他抗结核药物治疗耐多药肺结核的临床疗效。方法: 72例耐多药肺结核患者,随机分为试验组32例和对照组40例,观察治疗6、18个月末痰结核菌阴转率、胸部X线病灶和空洞变化情况等。结果: 治疗6个月末试验组的涂阳阴转率、培阳阴转率、病灶显吸率分别为 81.3%、84.4%、37.5%,均高于对照组的 57.5%、62.5%、15.0%,差异有统计学意义(P<0.05),其他结果2组无明显差异(P>0.05)。结论: 联合氯法齐明方案治疗耐多药肺结核可以提高疗效、缩短疗程,特别是在强化期具有明显的优势。