办公建筑室内垂直照度对视觉功效的影响评价

办公建筑是企事业单位人员从事各 类业务活动的重要场所。办公建筑的室内光 环境质量将直接影响人员的视觉功效和视力 健康,对提高办公场所的人居环境健康具 有重要意义。本文通过28名被试者对安菲莫 夫表读取完成时间和正确率的数据分析,结 合主观问卷调查反馈数据,结果发现：视觉 功效与垂直照度具有密切相关性;垂直照度 在300-600 lx区段内,21—40岁的人的舒适 度较高;不同年龄段对最佳垂直照度的需求 不同,性别对舒适度影响较小。本文对提升 办公场所室内光环境质量,优化办公照明设 计,改善办公场所人居环境,具有重要的指 导价值,同时将提高学者对垂直照度的关注 度,对未来照明建筑一体化概念的提出具有 重要意义。     

Energy‐Efficiency Evaluation of Gas Sweetening Based on Yield‐Energy‐Selectivity Indicators

The high‐sulfur gas sweetening process is energy consuming. To analyze its energy efficiency effectively, and look for ways to improve this process, a novel energy‐efficiency evaluation method based on the yield‐energy‐selectivity and efficiency coefficient methods was proposed. First, the yield, energy, and selectivity are selected as evaluation indicators to establish the yield‐energy‐selectivity evaluation model. Then, the coefficient and score of each indicator were determined by using the analytical hierarchy process and efficacy coefficient method, respectively. Finally, the proposed energy‐efficiency evaluation method was applied to the actual high‐sulfur gas sweetening process. The evaluation results were in good agreement with those obtained by actual experiences.     

全液压履带深孔钻车在任楼煤矿瓦斯钻孔施工中的应用

针对煤矿井下瓦斯抽采钻孔布孔密集,成孔速度快,钻机搬迁频繁等特点,任楼煤矿根据煤层赋存特征等地质条件,引进一台CMS1-6200/80型煤矿用全液压履带式深孔钻车,总结出本煤层顺层钻孔施工工艺。     

Modified Therapeutic Antibodies: Improving Efficacy

The prosperity of the biotherapeutics market reflects the feasibility and effectiveness of therapeutic antibodies for the treatment of cancers, inflammatory disorders, and refractory infections. As drawbacks emerge in clinical trials and practice, such as impeded binding, reduced effector functions, and frequent adverse reactions, modifications of therapeutic antibodies are unprecedently burgeoning in research and development (R&D). These modifications include: ① modified glycosylation; ② fragment of crystallizable domain (Fc) amino acid alterations; ③ cross-isotype or cross-subclass exchanges; ④ antibody–drug conjugates (ADCs); ⑤ single chain of variable region fragment (scFv) for chimeric antigen receptor T (CAR-T) cells; and ⑥ bispecific antibodies (bsAbs) in order to promote binding affinity, half-life in circulation, effectiveness toward target cells and, ultimately, to achieve overall improved efficacy. While many achievements have been made around the world in the past decades, China has been playing an active role in this realm, with its great demand for biotherapeutics with R&D potential. This review recapitulates the international progress that has been achieved with modified therapeutic antibodies, and then focuses on that of China in an independent section.     

The route towards a high efficacy PDP; influence of Xe partial pressure, protective layer, and phosphor saturation

PDP efficacy improvement factors are investigated. It is found that key elements for a high discharge efficiency are: a high Xe partial pressure combined with phosphor materials which show little saturation at high VUV load. In a color test panel a white luminance of 3500 cd/m² and an efficacy of 4 lm/W is realized for sustaining at 225 V.     

Reduction of Listeria monocytogenes contamination on produce – A quantitative analysis of common liquid fresh produce wash compounds

Contaminated produce has been identified as the cause of several listeriosis outbreaks in recent years. Listeria monocytogenes is widely distributed in the environment and complete prevention of produce contamination is therefore challenging. Mitigation options that reduce contamination on produce are valuable, especially for produce commodities that are commonly consumed fresh or minimally processed. We performed a systematic review and meta-analysis of the available peer-reviewed literature to evaluate the efficacy of liquid fresh produce wash compounds in reducing produce contamination with L. monocytogenes, and derive quantitative estimates of treatment efficacy for a variety of common liquid fresh produce wash compounds. Treatment efficacy differed considerably across produce commodities, with liquid fresh produce wash compounds generally showing considerably greater efficacy for some tested commodities than for other commodities. Most but not all of the evaluated liquid fresh produce wash compounds were significantly more effective in reducing L. monocytogenes contamination than water alone, with mean reductions in L. monocytogenes levels ranging from less than 1 log₁₀ cfu to more than 5 log₁₀ cfu. Liquid fresh produce wash compounds are therefore a possible tool for reducing contamination with L. monocytogenes, for certain produce commodities.     

花红片治疗急性盆腔炎60例临床观察

目的探讨花红片治疗急性盆腔炎的疗效。方法60例急性盆腔炎患者随机分为治疗组和对照组,每组30例,对照组给予抗生素,治疗组在对照组的基础上给予花红片治疗,观察2组的疗效。结果患者宫颈分泌物细菌培养以需氧菌最多,血抗体检测以沙眼衣原体最多。治疗组总有效率(96.7%)高于对照组(83.3%),差异具有统计学意义(P<0.05)。治疗组不良反应的发生率较低。结论花红片治疗急性盆腔炎临床疗效较好,且副反应较轻微。     

化妆品功效评价的生物物理学方法

对化妆品的生物物理学功效评价方法进行了综述,重点介绍了保湿、防晒、美白和皮肤表面轮廓的评价方法,另外还对皮肤表面油脂、除臭止汗剂、皮肤清洗和皮肤弹性的评价方法进行了简要介绍.     

人用皮内注射布氏菌活疫苗毒理及药效学研究

目的研究人用皮内注射布氏菌活疫苗的毒理及药效学作用,以评价其可行性。方法对布氏菌活疫苗进行小白鼠急性毒性试验、局部刺激试验、全身过敏试验、长期毒性试验及豚鼠皮肤变态反应试验并免疫小鼠,进行血清抗体检测。结果小鼠皮内注射布氏菌活疫苗的最大耐受量为1·0×109个菌,用布氏菌素注射足底,可引起明显的迟发型变态反应。局部刺激试验,只有注射1·0×109个菌的部位会在48h后化脓,但在1~2周内可自愈。全身过敏试验均未出现任何异常反应,毒性试验、各项血常规、血生化检查均未见显著差异,各脏器组织的病理学检查亦未见病理改变。免疫12周后,对豚鼠骨髓造血细胞亦无影响。对皮内免疫12周的豚鼠作背部皮肤变态反应试验,24~48h结果为阳性。皮内免疫小鼠14d后可测得小鼠体内有抗体产生,50d后测得小鼠体内抗体均呈强阳性,对照组小鼠14d与50d抗体检测均为阴性。结论毒理和药效学试验结果显示,布氏菌活疫苗用皮内注射的途径进行免疫是可行的。     

Superiority of collaborative learning with complex tasks: A research note on an alternative affective explanation

Kirschner, Paas, and Kirschner (2009c) used the theoretical framework of cognitive load to explain why the learning of a group of collaborating individuals was more efficient than that of individuals learning alone with high-complexity tasks but not with low-complexity tasks. The authors argued that collaboration circumvented the limitations of an individual’s working memory by creating an expanded cognitive capacity and by allowing for the distribution of cognitive load among group members. Inspired by research on efficacy, this study explored an alternative affective explanation of the results. By measuring the amount of mental effort learners expected to invest in working on a learning task before actually carrying out the task, this study showed that learners who had to collaboratively solve a high-complexity problem expected to invest less mental effort than learners who had to solve the problem alone. When confronted with low-complexity tasks, the expected amount of mental effort did not differ.