丝绸之路与中国早期玻璃艺术

我国在商、周之交,就开始了早期的中西交流,而张骞西行后又开辟了新的中外来往的交通路线。我国的玻璃业尽管没能发展为重要的手工业门类,但它始终在持续而缓慢的发展,更重要的是,正是由于玻璃业的非主流,在发展过程中凸显了外部因素的重要性。丝绸之路在中国古代玻璃艺术的发展过程中起到了重要作用。     

农产品电子商务网站的建设与研究

农产品电子商务是一个借助于网络平台新型的农产品销售模式。用户将自己的各类相关信息按照一定的格式输入到电子商务这个系统中,此系统就会协助完成合同的签订、分类、传递和款项收付等全套业务,为卖方以较高的价格出售农产品,买方以较低的价格购入原材料提供了一条非常好的途径,而且也减少了运输渠道所带来的额外消费。因此,农产品电子商务网站的发展对农业的发展和农民的收入的提高有着极大的意义。     

Characterization of acoustic signals due to surface discharges on H.V. glass insulators using wavelet radial basis function neural networks

A hybrid model incorporating wavelet and radial basis function neural network is presented which is used to detect, identify and characterize the acoustic signals due to surface discharge activity and hence differentiate abnormal operating conditions from the normal ones. The tests were carried out on cleaned and polluted high voltage glass insulators by using surface tracking and erosion test procedure of international electrotechnical commission 60587. A laboratory experiment was conducted by preparing the prototypes of the discharges. This study suggests a feature extraction and classification algorithm for surface discharge classification, which when combined together reduced the dimensionality of the feature space to a manageable dimension, by “marrying” the wavelet to radial basis function neural network very high levels of classification are achieved. Wavelet signal treatment toolbox is used to recover the surface discharge acoustic signals by eliminating the noisy portion and to reduce the dimension of the feature input vector. A radial basis function neural network classifier was used to classify the surface discharge and assess the suitability of this feature vector in classification. This learning method is proved to be effective by applying the wavelet radial basis function neural network in the classification of surface discharge fault data set. The test results show that the proposed approach is efficient and reliable.     

Model-guided evaluation of consumer products

An evaluation of a consumer product is presented as an example of how ergonomics models can guide data collection and interpretation by non-ergonomists. The product, a new cooking pan, was compared with its earlier counterpart on performance and safety tests for specific features. Model-guided evaluations produced data which could be well-fitted by linear relationships, and measures derived from the data could be interpreted in physical terms by engineers. This is now the standard methodology for pan evaluation in the client company.     

The Role of Chronic Inflammation in Various Diseases and Anti-inflammatory Therapies Containing Natural Products

Chronic inflammation represents a long-term reaction of the body's immune system to noxious stimuli. Such a sustained inflammatory response sometimes results in lasting damage to healthy tissues and organs. In fact, chronic inflammation is implicated in the development and progression of various diseases, including cardiovascular diseases, respiratory diseases, metabolic diseases, neurodegenerative diseases, and even cancers. Targeting nonresolving inflammation thus provides new opportunities for treating relevant diseases. In this review, we will go over several chronic inflammation-associated diseases first with emphasis on the role of inflammation in their pathogenesis. Then, we will summarize a number of natural products that exhibit therapeutic effects against those diseases by acting on different markers in the inflammatory response. We envision that natural products will remain a rich resource for the discovery of new drugs treating diseases associated with chronic inflammation.     

Screening of Inhibitors Targeting Heat Shock Protein 47 Involved in the Development of Idiopathic Pulmonary Fibrosis

Heat shock protein 47 (HSP47), a collagen-specific molecular chaperone, is causally related to fibrotic diseases, including idiopathic pulmonary fibrosis. The identification of Compounds that interfere with the HSP47-collagen interaction is essential for the development of relevant therapeutics. Herein, we prepared human HSP47 as a soluble fusion protein expressed in E. coli and established an assay system for HSP47 inhibitor screening. We screened a natural and synthetic Compound library established at Nagasaki University. Among 1023 Compounds, 13 exhibited inhibitory activity against human HSP47, of which three inhibited its function in a dose-dependent manner. Epigallocatechin-3-O-gallate, one of these three Compounds, is a typical polyphenol Compound derived from tea leaves. Structurally related Compounds were synthesized and examined for their activity, revealing a hydroxyl group at A-ring position 5 as important for its activity. The present findings provide valuable insight for the development of natural product-derived therapeutics for fibrotic diseases, including idiopathic pulmonary fibrosis.     

Nephrotoxicity of Herbal Products in Europe—A Review of an Underestimated Problem

Currently in Europe, despite the many advances in production technology of synthetic drugs, the interest in natural herbal medicines continues to increase. One of the reasons for their popular use is the assumption that natural equals safe. However, herbal medicines contain pharmacologically active ingredients, some of which have been associated with adverse effects. Kidneys are particularly susceptible to injury induced by toxins, including poisonous constituents from medicinal plants. The most recognized herb-induced kidney injury is aristolochic acid nephropathy connected with misuse of certain Traditional Chinese herbal medicines. Data concerning nephrotoxicity of plant species of European origin are scarce. Here, we critically review significant data of the nephrotoxicity of several plants used in European phytotherapy, including Artemisia herba-alba, Glycyrrhiza glabra, Euphorbia paralias, and Aloe). Causative mechanisms and factors predisposing to intoxications from the use of herbs are discussed. The basic intention of this review is to improve pharmacovigilance of herbal medicine, especially in patients with chronic kidney diseases.     

Identification of the Catalytic Residues in the Cyclase Domain of the Class IV Lanthipeptide Synthetase SgbL

Lanthipeptides belong to the family of ribosomally synthesized and post-translationally modified peptides (RiPPs) and are subdivided into different classes based on their processing enzymes. The three-domain class IV lanthipeptide synthetases (LanL enzymes) consist of N-terminal lyase, central kinase, and C-terminal cyclase domains. While the catalytic residues of the kinase domains (mediating ATP-dependent Ser/Thr phosphorylations) and the lyase domains (carrying out subsequent phosphoserine/phosphothreonine (pSer/pThr) eliminations to yield dehydroalanine/dehydrobutyrine (Dha/Dhb) residues) have been characterized previously, such studies are missing for LanL cyclase domains. To close this gap of knowledge, this study reports on the identification and validation of the catalytic residues in the cyclase domain of the class IV lanthipeptide synthetase SgbL, which facilitate the nucleophilic attacks by Cys thiols on Dha/Dhb residues for the formation of β-thioether crosslinks.     

玻璃钢制品拉拔模具的型腔表面处理工艺

玻璃钢制品拉拔工艺是较为先进的制造工艺之一，拉拔模具是决定玻璃钢制品质量好坏的关键。介绍了玻璃钢制品拉拔模具的型腔表面处理工艺，采用该处理工艺能有效地提高玻璃钢制品的质量。