香菇果蔬酱软罐头的研究

以香菇、桔皮、南瓜为主要原料,通过正交试验科学优选配方,采用真空浓缩新技术,研制了香菇果蔬酱软罐头。     

Targeting lncRNA H19/miR-29b/COL1A1 Axis Impedes Myofibroblast Activities of Precancerous Oral Submucous Fibrosis

Oral submucous fibrosis (OSF) is known as a potentially malignant disorder, which may result from chemical irritation due to areca nuts (such as arecoline). Emerging evidence suggests that fibrogenesis and carcinogenesis are regulated by the interaction of long noncoding RNAs (lncRNAs) and microRNAs. Among these regulators, profibrotic lncRNA H19 has been found to be overexpressed in several fibrosis diseases. Here, we examined the expression of H19 in OSF specimens and its functional role in fibrotic buccal mucosal fibroblasts (fBMFs). Our results indicate that the aberrantly overexpressed H19 contributed to higher myofibroblast activities, such as collagen gel contractility and migration ability. We also demonstrated that H19 interacted with miR-29b, which suppressed the direct binding of miR-29b to the 3′-untranslated region of type I collagen (COL1A1). We showed that ectopic expression of miR-29b ameliorated various myofibroblast phenotypes and the expression of α-smooth muscle actin (α-SMA), COL1A1, and fibronectin (FN1) in fBMFs. In OSF tissues, we found that the expression of miR-29b was downregulated and there was a negative correlation between miR-29b and these fibrosis markers. Lastly, we demonstrate that arecoline stimulated the upregulation of H19 through the transforming growth factor (TGF)-β pathway. Altogether, this study suggests that increased TGF-β secretion following areca nut chewing may induce the upregulation of H19, which serves as a natural sponge for miR-29b and impedes its antifibrotic effects.     

利29断块高温高盐油藏交联聚合物驱可行性研究

滨南油田利29断块是一高温高盐油藏。该文介绍了可用于高温高盐油藏的交联聚合物调驱体系，并以数值模拟为手段，对该断块交联聚合物驱浓度、段塞尺寸组合等参数进行了模拟，优选出交联聚合物驱油方案，并对其驱油效果进行了预测及评价。     

渤中29-4油田成藏分析及其勘探意义

渤中29-4油田是一个多层系复杂断块中型油气田,成藏分析表明,渤中29-4油田为明下段沉积期后形成,油气主要来自沙三段烃源岩,少量来自沙一段-沙二段;明化镇组天然气主要为生物降解气,古近系天然气为与油伴生的油型气,具有多期充注的特点。油气输导体系对油气分布控制作用明显,断层控制了下降盘油气运移,断层-砂体耦合形成的油气优势通道控制了断阶带、凸起区油气富集。渤中29-4油田勘探过程表明刻画油气优势运移通道是复杂断裂带寻找油气有利勘探区的有效手段。     

利用HT-2000网络转换器实现控制器的网络互连

工业控制领域需要一种高速，通用，廉价的网络，由于交换技术的发展，TCP／IP协议的采用以及网络结构的改变，使得Ethernet在工业控制领域中的应用成为可能。本文从HT－2000产品的结构出发，结合目前的一些控制的现状，详细介绍了采用HT－2000将各种控制器通过串口将现场总线的协议转换到Ethernet的方法及特点。     

Quasi-Interpolants with Tension Properties from and in CAGD

We present C² quasi-interpolating schemes with tension properties. The B-splines like functions used in the quasi-interpolanting schemes are parametric cubic curves and their shape can be easily controlled via tension parameters which have an immediate geometric interpretation. Applications to the problem of approximation of curves with shape-constraints are discussed.     

污泥灰替代粘土煅烧水泥熟料的~(29)Si固体高分辨核磁共振分析

城市污泥的灰分与水泥生料中粘土的成分类似,可被用作粘土的替代品煅烧生态水泥熟料,从而实现污泥的减量、无害、资源循环利用的可持续发展要求。本文用污泥灰替代粘土配置成掺量为0wt.%、3.58wt.%、7.16wt.%、10.73wt.%和14.31wt.%的生料并煅烧成熟料,再利用~(29)Si固体高分辨核磁共振技术分析五种熟料的矿物成分,通过固体核磁分峰拟合技术得出五种熟料的贝利特和阿利特的含量比值,结果表明随着污泥灰掺量的增加,熟料中贝利特含量增加,阿利特含量降低,污泥中微量元素的引入使β-C_2S更稳定,阻碍C_2S向C_3S的转化。     

MIR29A Impedes Metastatic Behaviors in Hepatocellular Carcinoma via Targeting LOX,LOXL2, and VEGFA

Primary liver cancer accounts for the third most deadly type of malignant tumor globally, and approximately 80% of the cases are hepatocellular carcinoma (HCC), which highly relies on the activity of hypoxia responsive pathways to bolster its metastatic behaviors. MicroRNA-29a (MIR29A) has been shown to exert a hepatoprotective effect on hepatocellular damage and liver fibrosis induced by cholestasis and diet stress, while its clinical and biological role on the activity hypoxia responsive genes including LOX, LOXL2, and VEGFA remains unclear. TCGA datasets were retrieved to confirm the differential expression and prognostic significance of all genes in the HCC and normal tissue. The Gene Expression Omnibus (GEO) dataset was used to corroborate the differential expression and diagnostic value of MIR29A. The bioinformatic identification were conducted to examine the interaction of MIR29A with LOX, LOXL2, and VEGFA. The suppressive activity of MIR29A on LOX, LOXL2, and VEGF was verified by qPCR, immunoblotting, and luciferase. The effect of overexpression of MIR29A-3p mimics in vitro on apoptosis markers (caspase-9, -3, and poly (ADP-ribose) polymerase (PARP)); cell viability and wound healing performance were examined using immunoblot and a WST-1 assay and a wound healing assay, respectively. The HCC tissue presented low expression of MIR29A, yet high expression of LOX, LOXL2, and VEGFA as compared to normal control. Serum MIR29A of HCC patients showed decreased levels as compared to that of normal control, with an area under curve (AUC) of 0.751 of a receiver operating characteristic (ROC) curve. Low expression of MIR29A and high expression of LOX, LOXL2, and VEGFA indicated poor overall survival (OS). MIR29A-3p was shown to target the 3′UTR of LOX, LOXL2, and VEGFA. Overexpression of MIR29A-3p mimic in HepG2 cells led to downregulated gene and protein expression levels of LOX, LOXL2, and VEGFA, wherein luciferase reporter assay confirmed that MIR29A-3p exerts the inhibitory activity via directly binding to the 3′UTR of LOX and VEGFA. Furthermore, overexpression of MIR29A-3p mimic induced the activity of caspase-9 and -3 and PARP, while it inhibited the cell viability and wound healing performance. Collectively, this study provides novel insight into a clinical-applicable panel consisting of MIR29, LOX, LOXL2, and VEGFA and demonstrates an anti-HCC effect of MIR29A via comprehensively suppressing the expression of LOX, LOXL2, and VEGFA, paving the way to a prospective theragnostic approach for HCC.     

Heterogenization of 12-tungstophosphoric acid on stabilized zeolite Y

Topics in Catalysis - 12-tungstophosphoric acid (PW12) has been supported on dealuminated zeolite Y, containing a secondary pore system with the predominant pore radii of 15 Å. The interaction...     

(Mindest-)Abstandsvorschriften; Liftanbauten; vorgeschobene Gebäudefront

Ein vom Erdgescho? hochgezogener Liftschacht stellt keinen vorspringenden Bauteil, sondern eine vorgeschobene Geb?udefront dar.