Dysregulation of the Enteric Nervous System in the Mid Colon of Complement Component 3 Knockout Mice with Constipation Phenotypes

Complement component 3 (C3) contributes to neurogenesis, neural migration, and synaptic elimination under normal and disease conditions of the brain, even though it has not been studied in the enteric nervous system (ENS). To determine the role of C3 in the regulatory mechanism of ENS during C3 deficiency-induced constipation, the changes in the markers of neuronal and interstitial cells of Cajal (ICCs), the markers for excitatory and inhibitory transmission of ENS, and expression of C3 receptors were analyzed in the mid colon of C3 knockout (KO) mice at 16 weeks of age. Prominent constipation phenotypes, including the decrease in stool parameters, changes in the histological structure, and suppression of mucin secretion, were detected in C3 KO mice compared to wildtype (WT) mice. The expression levels of the neuron specific enolase (NSE), protein gene product 9.5 (PGP9.5), and C-kit markers for myenteric neurons and ICCs were lower in the mid colon of C3 KO mice than WT mice. Excitatory transmission analysis revealed similar suppression of the 5-hydroxytryptamine (5-HT) concentration, expression of 5-HT receptors, acetylcholine (ACh) concentration, ACh esterase (AChE) activity, and expression of muscarinic ACh receptors (mAChRs), despite the mAChRs downstream signaling pathway being activated in the mid colon of C3 KO mice. In inhibitory transmission analysis, C3 KO mice showed an increase in the nitric oxide (NO) concentration and inducible nitric oxide synthase (iNOS) expression, while neuronal NOS (nNOS) expression, cholecystokinin (CCK), and gastrin concentration were decreased in the same mice. Furthermore, the levels of C3a receptor (C3aR) and C3bR expression were enhanced in the mid colon of C3 KO mice compared to the WT mice during C3 deficiency-induced constipation. Overall, these results indicate that a dysregulation of the ENS may play an important role in C3 deficiency-induced constipation in the mid colon of C3 KO mice.     

基于ICC阶调调整的陶瓷喷墨印刷颜色校正

目的 为了解决不同批次陶瓷制品的颜色一致性问题,提出一种基于ICC编辑的陶瓷喷墨制品颜色校正方法.方法 根据二分法原理,通过实验测量,找出网点阶调修正的颜色校正模型最佳校正参数a值,计算并绘制各单色通道色彩调整曲线Si.结果 应用经过Si值网点补偿校正后的ICC特性曲线,印刷并输出网点阶调测试色卡,测量得出各通道网点百分比的阶调值与基准值的平均差值减小到0.4％.结论 提出的基于ICC编辑的陶瓷喷墨印刷制品颜色校正方法有效解决了同一印前文件不同批次陶瓷制品颜色不一致的问题.     

Precise color capture using custom color targets

We have developed a procedure to achieve a high accuracy of color capture for digital still cameras for cultural heritage digitization. The procedure uses a standard color target and additional spectral measurements directly on the artwork. A set of complementary colors is determined thanks to an initial analysis of the digital image and a comparison with the standard color target. The developed procedure results in a digital copy that better represents the colors of the original than using only standard color targets.     

包装数码印刷的色彩管理

按照国际颜色协会ICC制定的开放式色彩管理标准，建立数码印刷的设备特征描述Profile文件．实现基于包装数码印刷的色彩管理。     

高术数字打样系列谈(二)——数字打样系统应用的关键技术

<正> 如今,数字打样在印刷领域已经得到普及,没有人再怀疑这项技术的可靠性。与前几年的观望态度相比,人们更多的考虑是怎样尽快满足自己打样用户对质量和效率的要求,怎样降低自己的成本,怎样更好地发挥这项技术的优势。数字打样相比于传统打样有着质量稳定性,操作容易性等特点。而所有这些是由于打样前就已经制订了一个质量标准。目前这个质量标准都是技术人员根据当地印刷质量特性而     

网上呼叫中心呼叫转换功能的实现

介绍了自行设计的一种基于H.323的网上呼叫中心实现各种呼转转移功能的实用系统。主叫方系统只有“选择呼叫转移”功能，被叫方系统可实现未注册转移、遇忙转移、无应答转移、无条件转移4种呼叫转移功能。     

基于AVAYA平台的自来水呼叫中心

本文讲述了AVAYADefinityG3si平台在自来水呼叫中心的应用,着重介绍了internet呼叫中心,简述了自来水业务功能。     

“Windows”平台下显示器色彩再现机理的研究和分析

计算机操作系统中的颜色管理设置对显示器的正确显色起着十分重要的作用。针对此问题,本文借助Windows7平台下的图形图像处理软件"Adobe PhotoShop",按照操作系统级和应用程序级颜色配置文件的不同,分3种情况设计了不同的颜色显示方案,并通过色差计算和色域比较的方法分析了操作系统级颜色配置文件在显示器颜色再现中所起的作用,所得重要结论如下:如果将操作系统级颜色配置文件设置为显示器自身的ICC特性文件,那么显示器的显色效果变化被看作是应用程序级ICC对颜色色度值进行重新定义的结果;如果将操作系统级颜色配置文件设置为其它ICC,则会发生从操作系统级ICC到应用程序级ICC的颜色空间转换,且两者的色域差别越大,转换后的显色效果变化就越剧烈。本研究结论对于正确应用显示器色彩管理具有一定的指导意义。     

ProfileMaker中色域映射选项对 ICC特性文件的影响

在Profile Maker 5.0中,基于LOGO Colorful、LOGO Chroma Plus和LOGO Classic 3个色域映射设置选项,分别制作了ICC特性文件,并针对其色域、密度范围和阶调曲线3个变量进行对比,研究了Profile Maker5.0中色域映射的选项对彩色输出设备ICC特性文件的影响,且计算了特性文件转换后的测试图色差值。结果表明,Profile Maker 5.0中,色域映射选项对应更改ICC曲线中色域范围和阶调复制曲线这两个参数,尤其是阶调复制曲线的改变非常明显。因此,Profile Maker 5.0中色域映射的选项对ICC特性文件内容有较大的影响,在实际应用中,应该合理进行选择。