超临界汽轮机用9Cr钢材料开发

超临界、超超临界汽轮机用ZG1Cr10MoVNbN不锈钢是一种改良型9％-12％Cr铁素体型不锈钢,要求材质具有优良的冶金质量和合理的成分搭配。文中采用AOD精炼炉精炼工艺技术,开发9Cr钢汽轮机铸钢件产品,掌握了该类材质的冶炼、焊接和热处理特性。     

ADAM10 and ADAM17—Novel Players in Retinoblastoma Carcinogenesis

A disintegrin and metalloproteinase (ADAM) family proteins, acting as sheddases, are important factors in a number of pathologies, including cancer, and have been suggested as promising therapeutic targets. The study presented focuses on the involvement of ADAM10 and ADAM17 in retinoblastoma (RB), the most common malignant intraocular childhood tumor. A significant correlation between ADAM17 expression levels and RB laterality and RB staging was observed. Levels of ADAM10 or ADAM17 regulating miRNAs miR-145, -152, and -365 were significantly downregulated in RB cell lines, and reduced miR levels with simultaneously upregulated ADAM10 and ADAM17 expression were found in RB patients. The involvement of both ADAMs analyzed in ectodomain shedding of the neuronal cell adhesion molecule L1 (L1CAM), shown to induce pro-tumorigenic effects in RB, was confirmed. Lentiviral ADAM10 and ADAM17 single or ADAM10/17 double knockdown (KD) induced caspase-dependent apoptosis and reduced cell viability, proliferation, growth, and colony formation capacity of RB cells. Moreover, differential phosphorylation of the serine/threonine kinase AKT was observed following ADAM17 KD in RB cells. Chicken chorioallantoic membrane (CAM) assays revealed that ADAM17 and ADAM10/17 depletion decreases the tumorigenic and migration potential of RB cells in vivo. Thus, ADAMs are potential novel targets for future therapeutic RB approaches.     

Dual Mode of Mitochondrial ROS Action during Reprogramming to Pluripotency

Essential changes in cell metabolism and redox signaling occur during the reprogramming of somatic cells into induced pluripotent stem cells (iPSCs). In this paper, using genetic and pharmacological approaches, we have investigated the role of electron transport chain (ETC) complex-I (CI) of mitochondria in the process of cell reprogramming to pluripotency. Knockdown of NADH-ubiquinone oxidoreductase core subunits S1 (Ndufs1) or subunit B10 (Ndufb10) of the CI or inhibition of this complex with rotenone during mouse embryonic fibroblast (MEF) reprogramming resulted in a significantly decreased number of induced pluripotent stem cells (iPSCs). We have found that mitochondria and ROS levels due course of the reprogramming tightly correlate with each other, both reaching peak by day 3 and significantly declining by day 10 of the process. The transient augmentation of mitochondrial reactive oxygen species (ROS) could be attenuated by antioxidant treatment, which ameliorated overall reprogramming. However, ROS scavenging after day 3 or during the entire course of reprogramming was suppressive for iPSC formation. The ROS scavenging within the CI-deficient iPSC-precursors did not improve, but further suppressed the reprogramming. Our data therefore point to distinct modes of mitochondrial ROS action during the early versus mid and late stages of reprogramming. The data further substantiate the paradigm that balanced levels of oxidative phosphorylation have to be maintained on the route to pluripotency.     

共存离子对八元瓜环与菲罗啉及其衍生物相互作用的影响

利用紫外光谱技术考察了一些离子对八元瓜环与1,10-菲罗啉及其衍生物作用的影响,结果显示:碱金属与碱土等金属离子及强酸根离子在一定的浓度范围内影响较小;H 和OH-影响较大,在pH=2～6时能生成包结比为1:2的包结物,在碱性条件下包结物分解;弱酸酸根离子对八元瓜环与菲罗啉及其衍生物的作用影响主要因为其水解产生的OH-的影响。可以通过调节溶液的酸度来控制瓜环对底物分子的包结作用。     

基于FPGA的DVB-ASI信号接收的实现

DVB-ASI(Digtal Video Broadcasting-Asynchronous Serial Interface)信号是一种高速的异步串行信号,在对其接收时常会出现误码率过高,解码困难等情况。以往DVB-ASI信号的接收常采用专用的通信接收处理芯片,成本较高,本文采用芯片为altera公司的EP2C8Q208C8,其中采用多重相位技术和过采样实现了时钟的恢复,有效地降低了误码率。然后对采样的数据进行字对齐,8B/10B解码,字同步,经过包同步后输出符合MPEG-2标准的TS(Transport Stream)流。系统的所占资源为610个LE,占芯片总资源的7.4%,工作频率为135MHZ。     

K60与动态集成模拟摄像头的智能车控制策略设计

本文设计了一种能在模拟跑道上顺利完成智能循迹的小车.该设计以嵌入式单片机MK60DN512ZLVQ10作为核心控制器,CMOS动态集成模拟摄像头OV5116作为图像传感器获取跑道图像信息.运用硬件二值化处理图像并提取赛道特征信息,通过控制舵机的转向和电机的转速,使车模能够按照规定的跑道和规则完成比赛.实验结果表明:该智能小车循迹精准,运行快速平稳,为相关循迹比赛和设计提供了参考.     

网络聚合技术在高性能地震资料处理系统中的应用

根据近年来中海油南海西部油田地震勘探资料高性能并行处理系统建设的成功案例。详细地介绍几个基于偏移技术计算的有代表性的HPC集群并行处理系统网络架构模型（包括千兆或万兆以太网和存储网络）的演变、趋势和技术特点。以及不同的网络在新建集群和系统扩充中整合与汇聚。     

青岛海滨大气PM_(2.5)与PM_(10)观测

2007年5～10月在黄海海滨青岛的观测表明大气PM_(2.5)和PM_(10)质量浓度呈同步变化,且变化范围较大.海陆风转换对海滨空气质量有重要影响:海风输送时空气较洁净,而陆风输送通常导致空气质量变差.PM_(2.5)、PM_(10)质量浓度与相对湿度(RH%)呈显著反相关,可能与RH%较高时多为海风输送有关.海风输送条件下较高的RH%和细粒子吸湿增长可能导致了此时PM_(2.5)对PM_(10)质量载荷的贡献率(64.7%)小于在海风/陆风混合输送和陆风输送条件下的贡献率(70.9%和77.5%).PM_(2.5)占PM_(10)质量载荷的72.3%,表明细粒子贡献显著.整个观测期PM_(10)未"达标"(PM_(10) 24 h均值 < 150 μg m~(-3),空气质量"良")的观测日仅占14 7%;但PM_(2.5)未达到美国EPA标准(PM_(2.5) 24 h均值 < 35 μg m~(-3)的观测日约为68.6%,表明大气细颗粒物PM_(2.5)的达标任务尚很艰巨.