GFAAS法测定LiMn2O4中的Pb和Cd

采用石墨炉原子吸收光谱法(GFAAs)测定锂离子电池正极材料LiMn2O4中杂质Pb和Cd的含量.探讨了HNO2浓度、Pb和Cd的灰化温度和原子化温度、基体改进剂对测定结果的影响.该方法的操作简单,准确度高,Pb的回收率为91.22%～93.75%,Cd的回收率为96.5%～108.6%;精密度好,两种元素测定的相对标准偏差RSD(n=lO)<5%.     

Obesity and Bone Health: A Complex Relationship

Recent scientific evidence has shown an increased risk of fractures in patients with obesity, especially in those with a higher visceral adipose tissue content. This contradicts the old paradigm that obese patients were more protected than those with normal weight. Specifically, in older subjects in whom there is a redistribution of fat from subcutaneous adipose tissue to visceral adipose tissue and an infiltration of other tissues such as muscle with the consequent sarcopenia, obesity can accentuate the changes characteristic of this age group that predisposes to a greater risk of falls and fractures. Other factors that determine a greater risk in older subjects with obesity are chronic proinflammatory status, altered adipokine secretion, vitamin D deficiency, insulin resistance and reduced mobility. On the other hand, diagnostic tests may be influenced by obesity and its comorbidities as well as by body composition, and risk scales may underestimate the risk of fractures in these patients. Weight loss with physical activity programs and cessation of high-fat diets may reduce the risk. Finally, more research is needed on the efficacy of anti-osteoporotic treatments in obese patients.     

萍水河水质空间分布特征及水质评价对比研究

流域水质直接关系到人体健康和生态安全。以萍水河向阳湖至何雁桥段为研究对象,分析其水质空间特征,综合4种方法进行水质评价,进一步利用多元统计和级别差方法对比分析水质评价结果。结果表明：1)COD、NH₃-N、TP和TN的最高浓度位于赤山桥处;上游(向阳湖-桥头村)和下游(赤山桥-何雁桥)总体水质较好,部分采样点TN、Fe和Mn轻度超标,污染程度明显弱于中游(桥头村-赤山桥)。2)最差水质级别均为Ⅴ类或劣Ⅴ类水,污染程度属严重污染及以上;单因子评价法确定总氮(TN)为首要污染指标;主成分分析法确定2个主成分,可解释为营养盐污染指标和地质沉积环境指标。3)4种方法两两之间呈显著正相关,相关系数为0.937～0.994,但水质级别表现出明显的差异性;级差法结果表明,3种综合水质评价方法的水质级别顺序为：内梅罗污染指数法<综合污染指数法<主成分分析法。研究成果可为流域水质评价工作和研究提供参考,同时为流域水资源开发利用和水环境保护及综合治理提供科学依据。     

Pathogenic Impact of α-Synuclein Phosphorylation and Its Kinases in α-Synucleinopathies

α-Synuclein is a protein with a molecular weight of 14.5 kDa and consists of 140 amino acids encoded by the SNCA gene. Missense mutations and gene duplications in the SNCA gene cause hereditary Parkinson’s disease. Highly phosphorylated and abnormally aggregated α-synuclein is a major component of Lewy bodies found in neuronal cells of patients with sporadic Parkinson’s disease, dementia with Lewy bodies, and glial cytoplasmic inclusion bodies in oligodendrocytes with multiple system atrophy. Aggregated α-synuclein is cytotoxic and plays a central role in the pathogenesis of the above-mentioned synucleinopathies. In a healthy brain, most α-synuclein is unphosphorylated; however, more than 90% of abnormally aggregated α-synuclein in Lewy bodies of patients with Parkinson’s disease is phosphorylated at Ser129, which is presumed to be of pathological significance. Several kinases catalyze Ser129 phosphorylation, but the role of phosphorylation enzymes in disease pathogenesis and their relationship to cellular toxicity from phosphorylation are not fully understood in α-synucleinopathy. Consequently, this review focuses on the pathogenic impact of α-synuclein phosphorylation and its kinases during the neurodegeneration process in α-synucleinopathy.     

四川盆地老气田二次开发优化技术及应用

经过近60年的开发,四川盆地的许多老气田已进入低压、低产的开发中后期,部分气田虽然已濒临废弃,但其中仍尚存较多剩余天然气资源未采出。通过梳理分析,认为具备二次开发条件的气田多存在地层水活跃形成水封难以解封、低渗透储量难动用等问题。为此,从老气田二次开发的定义出发,全面阐述了其技术路线及优选条件:(1)在建立缝洞系统多储渗体模式的基础上,采用压力重整曲线进行地质模型正演、生产动态反演特征曲线诊断,提出了复杂岩溶缝洞系统多储渗体识别及定量描述方法,结合U型管气水赋存新模式,形成了强水侵多缝洞系统天然气储量计算新技术;(2)建立孔、洞、缝三重介质数值模型,形成强水侵底水缝洞气藏"水平井排水+直井采气"排采井网模拟及效果评价新技术;(3)依托精细气藏描述形成的配套集成技术,重构气藏地质模型,分类评价气藏低渗透储量,结合井网优化、水平井地质导向、分段酸化压裂等工艺技术,进一步提高有效动用率;(4)建立多节点、多环节输气管网模型,形成区域性管网整体模拟优化及预测技术。实施效果表明,该二次开发技术在老气田产能建设、提高老气田采收率、延缓老气田产量递减、稳定老气田产量等方面均具有明显成效。     

粉防己碱对血管性痴呆大鼠齿状回S100B蛋白表达的研究

目的：探讨粉防己碱（Tet）对血管性痴呆（VaD）大鼠齿状回S100B蛋白表达的影响以及在血管性痴呆发病中的作用。方法：运用双侧颈总动脉永久性结扎（2-VO法）建立VaD大鼠模型,Nissl染色观察海马齿状回（DG）神经元内的尼氏小体的变化,免疫荧光观察海马DG区S100B的表达情况,F1uo-3/AM探针负载后检测各组大鼠海马内〔Ca2＋〕i浓度变化,探讨Tet改善VaD大鼠神经功能的分子机制。结果：Nissl染色后,Tet干预组大鼠海马DG区尼氏小体较模型组显著增多;免疫标记发现Tet干预组大鼠DG区神经元内S100B蛋白的表达量明显增多;Tet干预组大鼠海马〔Ca2＋〕i浓度显著下降（p〈0.05）。结论：Tet可改善大鼠脑缺血损伤引起的学习记忆能力障碍,可能与Tet下调S100B蛋白,抑制钙离子有关。     

自行火炮车体刚强度有限元分析

对某自行火炮车体在静态射击时的受力情况进行了分析，建立了；一体刚强度有限元分析的数学模型，给出了整；一网格图。采用三维空间板壳单元对最小射角、中间射角三种情况下的车体刚强度进行了计算，给出了计算结果，并对计算结果进行了分析。结果表明：火炮射击时对车体顶甲板的应力和变形影响最大，且顶甲板应力和变形随角的改变而明显改变；该车体结构设计合理，刚强度满足设计要求。最后提出了４点改善车体刚强度的建议。     

Androgen Receptor Gene Pathway Upregulation and Radiation Resistance in Oligometastatic Prostate Cancer

Stereotactic ablative body radiotherapy (SABR) is currently used as a salvage intervention for men with oligometastatic prostate cancer (PC), and increasingly so since the results of the Stereotactic Ablative Body Radiotherapy for the Comprehensive Treatment of Oligometastatic Cancers (SABR-COMET) trial reported a significant improvement in overall survival with SABR. The addition of androgen deprivation therapy (ADT) to localised prostate radiotherapy improves survival as it sensitises PC to radiotherapy-induced cell death. The importance of the androgen receptor (AR) gene pathway in the development of resistance to radiotherapy is well established. In this review paper, we will examine the data to determine how we can overcome the upregulation of the AR pathway and suggest a strategy for improving outcomes in men with oligometastatic hormone-sensitive PC.     

Artist Space 6: Generative computation and the arts

Cyberart incorporates interactive systems within artistic practices. The foundation for a theory of artistic production and creativity becomes expanded on the basis of a biological implication that is not dependent solely on aesthetic judgment. To communicate with computers and their high performance software stimulates artists’ imagination and there are types of interface or hardware that connect the natural system (especially the body) to the internal life of computers.     

地层（体）切片技术及其应用

地层（体）切片技术自提出后就得到了广泛的应用,不只是在地震沉积学上的应用,很多时候也应用于储层的预测方面,已成为目前全三维地震综合解释的常用手段,同时在应用过程中也出现了新的变化。将地震属性切片分为时间切片、沿层切片、地层切片和地层体切片,着重对地层切片和地层体切片进行了严格区分与详述。在对地层切片技术原理及应用条件分析基础上,结合其在大港油田滨海斜坡区的应用,指出应用地层切片技术时应注意其所适用的地震、地质条件,描述了参考等时面的提取方法及使用技巧等,为地层切片技术的应用提供借鉴。