EFFECTS OF HEXASULFOBUTYLATED C60 ON THE GASTRIC CIRCULAR MUSCLE OF GUINEA PIG

The effects of hexasulfobutylated (FC₄S), the fullerene derivative on the contraction of smooth muscle were tested pharmacologically on the circular muscle of stomach of guinea pigs. The effects of monomalonic acid C₆₀ (MMA C₆₀) on the same preparations were compared. The effects of those compounds on the taenia coli, portal vein and vas deferens of guinea pigs were also tested. The FC₄S did, while MMA C₆₀ did not elicit contracture of the circular muscle of stomach and taenia coli. Both FC₄S and MMA C₆₀ did not elicit contraction on the portal vein and on the vas deferens of the guinea pig. Prazosin (0.5 μM) or propranolol (0.5 μM) did not alter the FC₄S elicit contracture of the circular muscle of stomach. However, atropine (0.01, 0.1 and 1 μM), tetrodotoxin (0.1 μM) or low calcium medium decreased reversibly the FC₄S elicited contracture of the circular muscle of stomach. The effect of FC₄S on the contracture of the gastric muscles was also tested using various muscarinic receptor subtype antagonists. 4-DAMP (1 μM), muscarinic M3 receptor antagonist, and tropicamide (1 μM), muscarinic M4 receptor antagonist, did not alter the contracture elicited by FC₄S. Pirenzepine (0.1 μM), muscarinic M1 receptor antagonist, and methoctramine (0.25 μM), muscarinic M2 receptor antagonist, significantly decreased the FC₄S elicited contracture of the circular muscle. Atropine (1 μM) or tetrodotoxin (0.1 μM) completely blocked the FC₄S elicited contracture of the circular muscle of stomach. It is concluded that FC₄S elicited contracture of the circular muscle of stomach. The effect may be due to FC₄S acts on the cholinergic cells existed in the gastric muscle and indirectly activating the tetrodotoxin dependent releasing of the transmitters from the cells, then, activating the muscarinice M1, M2 receptors in the muscle eliciting the contractures.     

Synthesis and characterization of binary copolymers of methyl methacrylate with glycidyl methacrylate and 2‐hydroxy ethyl methacrylate as carriers for cellulase

Cellulase was immobilized directly on methyl methacrylate‐glycidyl methacrylate copolymer (MMA‐co‐GMA) and methyl methacrylate‐2‐hydroxy ethyl methacrylate copolymer (MMA‐co‐HEMA) by covalent attachment and crosslinking methods. The properties of the immobilized cellulase were investigated and compared with those of the free one. For the assays carried out through crosslinking method at 25°C and pH 7, the retained activities were found to be 91.92% and 74.63%, respectively, for MMA‐co‐GMA and MMA‐co‐HEMA crosslinked with 0.1% of 1‐cyclohexyl‐3‐(2‐morpholino‐ethyl) carbodiimide metho‐p‐toluenesulfonate (CMCT), respectively. The immobilized cellulase had better stability and higher retained activities with respect to pH, temperature, and storage stability than the free one. In the repeated use experiments, the immobilized cellulase using (MMA‐co‐GMA)‐CMCT (0.1%) and (MMA‐co‐HEMA)‐CMCT (0.1%) did not change after 10 and eight times of repeated use and maintained 67% and 62% from their original activities after 25 times, respectively. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010     

接枝交联明胶的研究(Ⅱ) 具有亲水性与亲油性接枝支链的交联明胶的合成和表征

首次以ＡＰＳ－Ｎａ２Ｓ２Ｏ３为引发体系，实现了甲基丙烯酸甲酯（ＭＭＡ）与Ｇｅｌｘ－ｇ－ＰＭＡＡ的接枝共聚反应，研究了反应规律；以ＩＲ表征了产物的结构；得到两亲性接枝共聚交联明胶，并对此类接枝改性明胶在各种溶剂中的溶胀行为作了初步的研究。     

基于APC技术的空间分集MIMO雷达目标检测

为有效地抑制样本随机性的影响,改善MIMO雷达的检测性能,通过分析已有的基于迭代最小均方误差(RMMSE)估计和迭代最大化输出信噪比(RMSNR)准则的APC技术,指出样本随机性是影响以迭代APC技术为基础的检验统计量检测性能的重要因素。提出基于RMMSE和RMSNR的多通道多脉冲平均APC(MMA-APC)技术,并以此为基础构造检验统计量。基于自适应脉冲压缩(APC)技术研究了空间分集MIMO雷达相参脉冲串条件下的目标检测问题。     

交通事故现场防入侵设备设计

为了提高交通事故现场防护水平和预防二次事故,利用C8051F020单片机以及MMA7260,MicroMag2等传感器设计了一种设备,对车辆入侵进行检测,迅速有效地判断车辆是否侵入防护现场,根据检测结果实现报警。     

Human serum albumin adsorption on poly[(glycidyl methacrylate)‐co‐(methyl methacrylate)] beads modified with a spacer‐arm‐attached L‐histidine ligand

Poly(GMA/MMA) beads were synthesized from glycidyl methacrylate (GMA) and methyl methacrylate (MMA) in the presence of a cross‐linker (i.e. ethyleneglycol dimethacrylate) (EGDMA) via suspension polymerization. The epoxy groups of the poly(GMA/MMA) beads were converted into amino groups with either ammonia or 1,6‐diaminohexane (i.e. spacer‐arm). An L ‐histidine ligand was then covalently immobilized on the aminated (poly(GMA/MMA)‐AH) and/or the spacer‐arm attached (poly(GMA/MMA)‐SAH) beads using glutaric dialdehyde as a coupling agent. Both affinity adsorbents were used in human serum albumin (HSA) adsorption/desorption studies under defined pH, ionic strength or temperature conditions in a batch reactor. The spacer‐arm attached affinity adsorbent resulted in an increase in the adsorption capacity to HSA when compared to the aminated counterpart (i.e. poly(GMA/MMA)‐AH). The maximum adsorption capacities of the affinity adsorbents were found to be significantly high, i.e. 43.7 and 80.2 mg g^?1 (of the beads), while the affinity constants, evaluated by the Langmuir model, were 3.96 × 10^?7 and 9.53 × 10^?7 mol L^?1 for poly(GMA/MMA)‐AH and poly(GMA/MMA)‐SAH, respectively. The adsorption capacities of the affinity adsorbents were decreased for HSA by increasing the ionic strength, adjusted with NaCl. The adsorption kinetics of HSA were analysed by using pseudo‐first and pseudo‐second‐order equations. The second‐order equation fitted well with the experimental data. Copyright © 2005 Society of Chemical Industry     

NEW HMM ALGORITHM FOR TOPOLOGY OPTIMIZATION

0 INTRODUCTIONTwo types of algorithms are currently widely used instructure optimization. The first one is the optimization criteria(OC) method. The OC method can be understood directly, but it isdifficult to deduce different types of optimization criteri…     

基于MMA7260和μPD78F0547的水泵振动信号采集器

基于单片机μPD78F0547和加速度传感器MMA7260的水泵振动信号采集器的设计。该振动信号采集器可以实现对水泵振动信号的实时采集,并能通过RS232接口将振动数据传送到上位机,具有高灵敏度、高速、低成本、方便和实用等优点。以水泵正常运行和发生支座松动、不对中故障为例,进行水泵振动信号采集与小波消噪处理实验。实验表明该振动信号采集器可以很好地获取水泵各种工况下的振动信号。     

汽车安全气囊加速计MMA2204D及其应用

介绍了低功耗、高精度,并带有集成信号放大、信号处理、低通滤波和补偿的硅电容加速度计MMA2204D的主要性能,给出了将MMA2204D应用于汽车安全气囊的应用方法。     

基于车载传感信息融合的电动汽车驾驶行为辨识

本文的主要目的是基于信息融合的方法设计出一套能准确辨识出驾驶行为的系统.本系统使用六轴加速度计采集加速度信息,通过多尺度多重分形(MMA)算法(首次将该算法用作特征提取的方法)从加速度信号中提取出可反映不同驾驶行为的波动特征.并采集电动汽车的OBD接口获取的包括速度、功率、电流等车载OBD信息并提取特征.分别通过随机森林(RF)算法对驾驶员的驾驶行为进行辨识.提出一种新的信息融合的方法,采用该方法对加速度信息和OBD信息进行融合,发现信息融合的方法可以更有效的辨识出电动汽车的驾驶行为.