Photoresponsive Protein–Graphene–Protein Hybrid Capsules with Dual Targeted Heat‐Triggered Drug Delivery Approach for Enhanced Tumor Therapy

A novel photo‐responsive protein–graphene–protein (PGP) capsule that doubles as a photothermal agent with core/shell structure is constructed by anchoring reduced graphene oxide nanosheets on one‐component protein (lactoferrin) shell through a double emulsion method. PGP capsules can transport fully concealed hydrophilic anticancer cargo, doxorubicin (Dox), with a large payload (9.43 μmol g^‐1) to be later unloaded in a burst‐like manner by photo‐actuation triggered by near‐infrared irradiation. Being biocompatible yet with a high cancer cell targeting efficiency, PGP capsules have successfully eradicated subcutaneous tumors in 10 d following a single 5 min NIR irradiation without distal damage. Besides, the photochemothermal therapy of PGP capsules eradicates tumor cells not only in the light‐treating area but also widely light‐omitted tumor cells, overcoming the tumor recurrence due to efficient cell killing efficacy. These results demonstrate that the PGP capsule is a potential new drug delivery platform for local‐targeting, on‐demand, photoresponsive, combined chemotherapy/hyperthermia for tumor treatment and other biomedical applications.     

Synergy of Pickering Emulsion and Sol‐Gel Process for the Construction of an Efficient,Recyclable Enzyme Cascade System

An efficient, easily recyclable enzyme cascade system based on nanoparticle‐stabilized capsules (NPSCs) is constructed through a synergy of a Pickering emulsion and sol‐gel process. Specifically, oligodopa‐coated titania nanoparticles (biomimetic titania) containing the first enzyme (FateDH) are synthesized through a bioadhesion‐assisted biomimetic mineralization approach. The biomimetic titania is then spontaneously assembled at the interface between the oil phase (hexadecane/butyl titanate (BuTi) mixture) and water phase during the formation of Pickering emulsions. The sol‐gel process of BuTi can produce not only butanol for assisting the formation of Pickering emulsions but also titania gel particles (sol‐gel titania) for cross‐linking the biomimetic titania through catechol‐titanium chelating. The NPSCs obtained, which contain the first enzyme, conjugate the second enzyme (FaldDH) onto the surface for constructing the enzyme cascade system. The system exhibits high activity and stability, particularly, superior recyclability for conversion of CO₂ into formaldehyde. In detail, the system shows a formaldehyde yield of 50.0%, and can quickly float onto the air/water interface soon after stopping the agitation of reaction mixtures, which ensures that the formaldehyde yield keeps almost unaltered after 10 times recycling. This study will be useful for facile construction of a wealth of catalytic systems with efficient, recyclable attributes.     

功率型白光LED平面涂层技术研究

基于水溶性感光胶的白光LED表面涂层技术,阐述了含有荧光粉感光胶悬浮液的配比和封装结构对白光LED出光效率的影响,提出了相应的改进措施,通过实验证实提高了白光LED器件的整体性能.同时,对利用该法得到的功率型白光LED进行了光衰减测试,LED在700mA电流下点亮168 h后,光输出为初始光输出的95.95%,满足实用要求.     

乳化炸药油水相流量控制

以乳化炸药生产线油、水相流量控制系统为研究对象,分析油、水相流量添加过程的滞后性,针对传统PID控制理论的不足,详细分析了自校正PID理论,采用自校正PID控制策略来实现流量的实时控制。现场运行情况表明,这种控制策略符合工业实际,采用的控制器稳定可靠。     

聚酰胺-胺星形聚醚原油破乳剂的合成与性能

以1.0G、2.0G、3.0G 乙二胺为核制备了星形大分子聚酰胺-胺,并与环氧丙烷、环氧乙烷进行烷氧基化反应制备了一系列具有多分支结构的二嵌段聚醚类破乳剂。采用浊点法测定了系列破乳剂的亲水亲油平衡值,单滴法测量了降低油水界面膜强度的能力,针对油包水型原油乳状液进行了破乳性能研究。结果表明:该系列聚醚破乳剂具有良好的界面活性,对油包水型原油乳状液脱水率超过90%,具有良好的破乳性能和适应性;破乳剂起始剂聚酰胺-胺代数越高,分支越多,所合成的聚醚破乳剂性能越好;随着聚酰胺-胺的代数及破乳剂质量浓度的增加,油滴液膜排液时间缩短,半生命期减小,破裂速率常数增大。     

混沌脉宽调制电场激励油中液滴振动动力学特性分析

常用的恒定脉冲电场进行破乳脱水处理过程中,由于乳化油中液滴粒径的动态变化导致了电场最佳破乳频率的不确定,使得电场破乳效果受到了影响,进而提出了运用混沌脉宽调制电场实现乳化油高效破乳处理。以油中单液滴为研究对象,建立了液滴混沌脉宽调制电场振动动力学模型,数值分析了液滴的振动特性。结果表明：电场频率对液滴振动产生了直接影响,当施加的电场频率等于或接近液滴共振频率时,液滴发生共振;当电场频率小于液滴共振频率一半时,液滴振动频率高于电场频率;反之,液滴振动频率与电场频率一致。此外,不同粒径的液滴在混沌脉宽调制电场中的振动响应均存在滞后现象,粒径越大,其响应滞后越明显,混沌振动程度也会随之降低。     

原油乳状液稳定性研究 Ⅱ.原油成分对原油乳状液稳定性的影响

原血成分的表面活性物质及其细微固体颗粒,在油水界面上相互作用是原油乳状液其有稳定性的主要原因。本文采用简单的方法将原油中众多的物质分成两大类,并根椐它们单独时或混合后对癸烷/水乳状液稳定性作用的特征,将其分别称为原油乳化剂和原油破乳剂。试验表明,原油乳状液稳定性的高低主要取决于所含的这两大类物质的多少和相对比例,其相对重要性可由界面张力定性地反映出来;并且由原油/水界面张力的大小可以定性地评估原油乳状液的稳定性。     

热镀锌基板表面缺陷遗传性影响分析及相应措施

研究了酸轧产品表面质量对镀锌产品表面质量的影响,探讨了酸洗质量、乳化液残留、带钢表面粗糙度、冷硬卷表面带状缺陷对镀锌产品表面质量缺陷,如带状锌花偏小或无锌花、片状锌花偏小、线状锌花偏小的影响,并确定了酸洗及轧制过程的关键工艺控制措施,使镀锌产品一级品率提升了1.5% 。     

防雾包装材料用助剂的研究

目的制备一种功能性核-壳结构复合微球。方法以过硫酸铵(APS)引发剂引发苯乙烯(St)、丙烯酸(AA)和甲基丙烯酸甲酯(MMA)进行无皂乳液聚合。采用红外光谱分析仪(FT-IR)对功能微球的结构进行表征,通过扫描电子显微镜(SEM)和激光衍射粒度分析仪对产物的形貌、粒径大小及分布进行分析,采用接触角测定仪(OCA)对材料薄膜与水的接触角进行测定。讨论控制功能微球形态、粒径及分布的影响因素,并研究功能微球薄膜在不同温度下亲水性的变化。结果功能微球为亚微米级核-壳结构,该微球以PSt为核,以亲水性的MMA-AA链段为壳,单分散性良好。结论在25℃时功能微球涂覆薄膜与水的接触角为3°具有最佳的超亲水性能。     

破乳菌B_3菌株分批发酵动力学分析

以从采油废水中筛选到的一株高效生物破乳菌株B3为试验菌株,为认识其发酵机理并指导发酵工艺设计,利用分批发酵的方法研究破乳菌株B3菌体生长和葡萄糖消耗情况.根据分批发酵实验结果,采用Logistic方程和Lu-edeking-Piret方程,建立破乳菌株B3的菌体生长和葡萄糖消耗动力学模型,利用拟线性法求得破乳菌分批发酵的动力学模型参数.模型计算值与实验值能够较好地拟合,相对误差分别小于9%和6%,表明所建立的动力学模型能够反映B3破乳菌株发酵过程的动力学特征.