Modelling of the mist formation in a segmented grinding wheel system

It has been found that using a segmented grinding wheel with a fluid chamber can significantly minimise the quantity of coolant while improving the ground surface integrity. The present investigation aims to explore the fluid flow mechanism in such a wheel system. To this end, the Weber theory for Newtonian jet instability was applied to quantitatively determine the contribution of coolant flow rate to mist and ligament modes. A semi-analytical model was then developed to predict the mist flow rate by taking into account both the grinding parameters and fluid properties. It was shown that the model prediction was in good agreement with experimental measurements. Because of the comprehensive integration of variables in the formulation, the model provides a good fundamental understanding of the mist formation and offers a practical guideline for the selection and use coolant in minimising the mist flow rate.     

Electrochemically deposited polypyrrole films and their characterization

Ionically conductive polypyrrole films have been deposited at 295 K from anhydrous acetonitrile, acetonitrile/H₂O and NaBF₄ aqueous solutions onto platinum, mild steel and stainless steel discs, using cyclic voltammetry, potentiostatic and galvanostatic techniques. Cyclic voltammetry of the polymer films has been studied as a function of water content of the acetonitrile solvent, polypyrrole concentration and potential sweep rate. Potentiostatic growth of thicker (< 30 micron) films on stainless steel allowed free-standing polypyrrole membranes to be produced. Well adherent and conductive films were deposited at constant potential in stirred solutions from acetonitrile electrolytes containing 1% (v/v) of water. The membrane resistivity of the reduced films in 0.5 mol dm^− 3 KCl_(aq) at 295 K was ≈ 1 × 10⁶ Ω cm, while the resistivity of the oxidised membrane was 2700 Ω cm.     

块体金属基纳米复合材料的制备技术

金属基纳米复合材料（MMNCs）兼有高的强度和良好的韧性，是金属基复合材料（MMCs）的一个重要发展方向。但是，无论是采用液相铸造法还是固相烧结法，欲制备纳米颗粒增强的块体金属基复合材料均相对困难。综述了国内外制备块体金属基纳米复合材料的工艺原理、结构特征和主要性能，并展望了其发展和应用前景。     

铸钢件准固态区域应力,应变数值模拟及热裂机制

对ＺＧ４５实验热裂试棒的数种工况进行了应力－应变的数值模拟，对热裂形成机制进行了讨论。研究认为：热裂起源于Ｂｉｎｇｈａｍ体，是塑性变形超过Ｂｉｎｇｈａｍ体塑性储备值所致。     

Theoretical analysis of β-LaNi5Hx(5≤x≤8): structure and energetics

The calculations of total energy, band structure, and electronic density of states and Mulliken population analysis of β-LaNi5 Hx (5≤x≤8) were performed by adopting the method of total energy based on the density functional theory. The augmented plane wave function was selected as the basis set in combination with ultra-soft pseudo-potential technology. The influence of the amount of H absorbed in alloys was discussed in terms of geometry, electronic structure and thermodynamic derived from calculated results. The results show that the amount of H absorbed and the preferred site occupation of the absorbed hydrogen atoms were controlled by the position of Hbands and the energy gap between H-bands and conduction bands. The β-phase hydrides of LaNi5 are most stable when hydrogen atom capacity coating in the range of 6 - 7.     

一种引入通信的多移动机器人编队方法*

提出以视觉跟踪为基础并引入通信进行多机器人的编队控制方法,根据需要编写了一种新的通信协议,采用闭环l-Φ实现编队算法.这种多机器人编队控制避免了视觉系统的局限,能够更好地在复杂未知环境中协作完成任务,解决了编队控制的无反馈和实时性不高的问题,使得机器人能够准确迅速地进行跟踪和通信编队,一起顺利达到目标点.试验结果证明了该方法的有效性.     

Screening of Inhibitors Targeting Heat Shock Protein 47 Involved in the Development of Idiopathic Pulmonary Fibrosis

Heat shock protein 47 (HSP47), a collagen-specific molecular chaperone, is causally related to fibrotic diseases, including idiopathic pulmonary fibrosis. The identification of Compounds that interfere with the HSP47-collagen interaction is essential for the development of relevant therapeutics. Herein, we prepared human HSP47 as a soluble fusion protein expressed in E. coli and established an assay system for HSP47 inhibitor screening. We screened a natural and synthetic Compound library established at Nagasaki University. Among 1023 Compounds, 13 exhibited inhibitory activity against human HSP47, of which three inhibited its function in a dose-dependent manner. Epigallocatechin-3-O-gallate, one of these three Compounds, is a typical polyphenol Compound derived from tea leaves. Structurally related Compounds were synthesized and examined for their activity, revealing a hydroxyl group at A-ring position 5 as important for its activity. The present findings provide valuable insight for the development of natural product-derived therapeutics for fibrotic diseases, including idiopathic pulmonary fibrosis.     

Dynamic “Molecular Portraits” of Biomembranes Drawn by Their Lateral Nanoscale Inhomogeneities

To date, it has been reliably shown that the lipid bilayer/water interface can be thoroughly characterized by a sophisticated so-called “dynamic molecular portrait”. The latter reflects a combination of time-dependent surface distributions of various physicochemical properties, inherent in both model lipid bilayers and natural multi-component cell membranes. One of the most important features of biomembranes is their mosaicity, which is expressed in the constant presence of lateral inhomogeneities, the sizes and lifetimes of which vary in a wide range—from 1 to 10³ nm and from 0.1 ns to milliseconds. In addition to the relatively well-studied macroscopic domains (so-called “rafts”), the analysis of micro- and nanoclusters (or domains) that form an instantaneous picture of the distribution of structural, dynamic, hydrophobic, electrical, etc., properties at the membrane-water interface is attracting increasing interest. This is because such nanodomains (NDs) have been proven to be crucial for the proper membrane functioning in cells. Therefore, an understanding with atomistic details the phenomena associated with NDs is required. The present mini-review describes the recent results of experimental and in silico studies of spontaneously formed NDs in lipid membranes. The main attention is paid to the methods of ND detection, characterization of their spatiotemporal parameters, the elucidation of the molecular mechanisms of their formation. Biological role of NDs in cell membranes is briefly discussed. Understanding such effects creates the basis for rational design of new prospective drugs, therapeutic approaches, and artificial membrane materials with specified properties.     

An electrochemical method for the preparation of Mg–Li alloys at low temperature molten salt system

Mg–Li alloys have been prepared by electrolysis in a molten salt electrolyte of 50% LiCl–50% KCl (mass%) at low temperature of 420–510 °C. The effects of electrolytic temperature and cathodic current density on alloy formation rate and current efficiency were studied. For the deposition of metallic lithium on the cathode consisting of solid Mg and liquid Mg–Li, both electrolytic temperature and cathodic current density have no obvious influence on current efficiency; while for the deposition of metallic lithium on the solid magnesium cathode, both electrolytic temperature and cathodic current density greatly affect alloy formation rate and current efficiency. The optimum electrolysis condition is—molten salt mixture, LiCl:KCl = 1:1 (mass%), electrolytic temperature: 480 °C, cathode current density: 1.13 A cm⁻². Mg–Li alloys with low lithium content (about 25 wt% Li) were prepared via electrolysis at low temperature following by thermal treatment at higher temperature.     

An extension of Wagner's analysis of competing scale formation

Wagner's criterion to predict the minimum concentration of solute (N _B(min) ⁰ )necessary for the exclusive formation of its scale has been modified to incorporate both thermodynamic and kinetics requirements. The analysis presented here involves a receding alloy/scale interface for which the composition of the alloy at this interface is governed by thermodynamic equilibrium between the two competing scale phases and the base alloy. This is a more rigorous analysis than that of Wagner's, who assumed the alloy/scale interface to be immobile and the solute composition at the interface to be zero. A comparison is made between values of N _B(min) ⁰ found experimentally and those predicted by Wagner's and the present criterion for a number of alloy-gas systems. It is shown that the criterion developed in the present analysis can often provide a better approximation of the actual N _B(min) ⁰ .The expressions derived from the present analysis have been extended also in a semiquantitative manner to provide a criterion for the minimum amount of solute in the alloy required for the transition from internal to external scale formation.