利用SPR生物传感器检测缺血修饰白蛋白

缺血修饰白蛋白(IMA)的检测对心肌缺血的早期诊断和治疗具有重要意义。利用纳米金颗粒和混合巯基自组装于金膜表面上,研制了一种快速检测IMA的表面等离子体共振(SPR)生物传感器。同时比较了直接法和抑制法的检测下限。结果表明:直接检测法可以检测到393ng/L的IMA,而抑制检测法检测限小于5.0 ng/L。与现有的IMA检测方法相比,SPR生物传感器具有特异性好、检测下限低以及检测耗时短等优点。     

AT91SAM7X的多路USB2.0数据采集系统

随着SoC技术的发展,应用单芯片满足应用中的各种需求已经成为一种趋势。将更多设计中必需的通用外设集成到芯片内部,不但可以降低成本,而且可以提高系统的稳定性。本文给出一种基于AT91SAM7X的单芯片多路USB2.0数据采集系统的解决方案。芯片本身集成USB2.0接口和8路10位A/D转换器,外部标准的-5～＋5V信号可以直接接入本系统进行采集,达到了降低成本、提高系统稳定性的目的。     

GaAs功率场效应管失效中源一漏烧毁现象的SEM／SAM研究

采用光学显微镜、扫描电子显微镜（ＳＥＭ）及扫描俄歇微探针（ＳＡＭ）等表面分析技术对ＧａＡｓ功率场效应管（ＦＥＴ）源－漏烧毁失效现象进行了分析研究。ＳＥＭ分析结果表明，源－漏烧毁失效的表面形貌状况较为复杂，烧伤区域的表面形态不尽一致。有源极烧毁较为严重的情况，也有漏极烧伤较严重的情况。ＳＡＭ分析结果说明，源－漏烧毁ＦＥＴ中烧毁处附近的外表完好的源、漏条Ａｕ薄膜下欧姆接触金属薄膜层已完全消失，烧毁源、漏条部位表面化学元素有Ｃ、Ｏ、Ｔｉ、Ｎ和Ｇａ，其中Ｃ、Ｏ在表层几十纳米深度内均有相当高的含量。结合分析结果，讨论了源－漏烧毁的物理机理。     

基于IEEE1451标准的物联网网关协议转换

为解决物联网中传感网络与互联网间协议转换,提出一种基于 IEEE 1451标准的物联网网关的体系结构。该体系结构利用 IEEE 1451标准的3个子系列：IEEE 1451.0、IEEE 1451.2、IEEE 1451.5,通过 AT91SAM9X35微处理器实现网关,解决了物联网网关协议转换问题,使得网关分别具有有线和无线的接入能力。     

Development of environmental scanning electron microscopy electron beam profile imaging with self-assembled monolayers and secondary ion mass spectroscopy

A method for demonstrating the scattering of the primary electron beam in the presence of a gas has been developed. A self-assembled decanethiol monolayer is damaged by primary beam electrons. The damaged portion of the mono-layer is exchanged with another thiol-containing molecule by immersion in solution. The resulting film is imaged using a secondary ion mass spectrometer. Three-dimensional reconstruction of the data yields a representation of scattered electrons in the gaseous environment of the environmental scanning electron microscope.     

Is the SAM phantom conservative for SAR evaluation of all phone designs?

The specific anthropomorphic mannequin (SAM) phantom was designed to provide a conservative estimation of the actual peak spatial specific absorption rate (SAR) of the electromagnetic field radiated from mobile phones. However, most researches on the SAM phantom have been based on early phone models. Therefore, we numerically analyze the SAM phantom to determine whether it is sufficiently conservative for various types of mobile phone models. The peak spatial 1‐ and 10‐g averaged SAR values of the SAM phantom are numerically compared with those of four anatomical head models at different ages for 12 different mobile phone models (a total of 240 different configurations of mobile phones, head models, frequencies, positions, and sides of the head). The results demonstrate that the SAM phantom provides a conservative estimation of the SAR for only mobile phones with an antenna on top of the phone body and does not ensure such estimation for other types of phones, including those equipped with integrated antennas in the microphone position, which currently occupy the largest market share.     

两种基于北斗BDM100模块的家庭监护终端设计

针对家庭监护中老人实时定位问题,结合北斗全球卫星定位系统和北斗模块BDM100,分别采用3G和2G模块设计了两种解决方案。3G方案中,采用AT91SAM9260芯片作为主控芯片,自定义通信协议,并封装了若干基于Linux操作系统的通信函数,具有良好的扩展性和稳定性。2G模块则采用LPC1766芯片,设计了具有良好健壮性的软件,成本低,对于单一需求的用户具有很好的适应性。     

兰州北编组站综合自动化系统

介绍了兰州北编组站概况,详细阐述了编组站综合自动化（S A M）系统的构成和过程控制系统。     

Formation and characterization of low resistivity sub-100 nm copper films deposited by electroless on SAM

Thin Cu films of microelectronic quality and low electrical resistivity were created by electroless deposition (ELD) onto SiO₂ surface modified first with self-assembled monolayer (SAM) of 3-aminopropyltrimethoxysilane (APTMS) and activated then by 5 nm gold nano-particles (AuNPs). The presence of highly oriented amino-terminated SAM was revealed by XPS and ToF-SIMS analyses. The Cu films were deposited in boron- and phosphorous-free tartrate/formaldehyde electrolyte. Controlling the deposition rate via the solution pH permitted a minimum value in resistivity ρ. XPS depth profile revealed that diffusion of Cu into SiO₂ modified by APTMS did not take place after annealing at 220 °C, 4 h. Moreover, annealing resulted in the drop of electrical resistivity to ρ = 4 ± 0.4 μΩ cm for the films with the thickness of 35-100 nm. This value of ρ is several times smaller than those reported in literature for sub-100 nm Cu films deposited by electroless on different SAMs. It is speculated that nano-scale porosity and corrugated structure observed by HRTEM and AFM in the ELD Cu films contribute to the resistivity. The obtained results demonstrate a viable route for formation of low resistivity, sub-100 nm Cu films on dielectrics for microelectronic application.     

An Engineered E. coli Strain for Direct in Vivo Fluorination

Selectively fluorinated compounds are found frequently in pharmaceutical and agrochemical products where currently 25–30 % of optimised compounds emerge from development containing at least one fluorine atom. There are many methods for the site-specific introduction of fluorine, but all are chemical and they often use environmentally challenging reagents. Biochemical processes for C−F bond formation are attractive, but they are extremely rare. In this work, the fluorinase enzyme, originally identified from the actinomycete bacterium Streptomyces cattleya, is engineered into Escherichia coli in such a manner that the organism is able to produce 5′-fluorodeoxyadenosine (5′-FDA) from S-adenosyl-l -methionine (SAM) and fluoride in live E. coli cells. Success required the introduction of a SAM transporter and deletion of the endogenous fluoride efflux capacity in order to generate an E. coli host that has the potential for future engineering of more elaborate fluorometabolites.