NMDA and P2X7 Receptors Require Pannexin 1 Activation to Initiate and Maintain Nociceptive Signaling in the Spinal Cord of Neuropathic Rats

Pannexin 1 (Panx1) is involved in the spinal central sensitization process in rats with neuropathic pain, but its interaction with well-known, pain-related, ligand-dependent receptors, such as NMDA receptors (NMDAR) and P2X7 purinoceptors (P2X7R), remains largely unexplored. Here, we studied whether NMDAR- and P2X7R-dependent nociceptive signaling in neuropathic rats require the activation of Panx1 channels to generate spinal central sensitization, as assessed by behavioral (mechanical hyperalgesia) and electrophysiological (C-reflex wind-up potentiation) indexes. Administration of either a selective NMDAR agonist i.t. (NMDA, 2 mM) or a P2X7R agonist (BzATP, 150 μM) significantly increased both the mechanical hyperalgesia and the C-reflex wind-up potentiation, effects that were rapidly reversed (minutes) by i.t. administration of a selective pannexin 1 antagonist (10panx peptide, 300 μM), with the scores even reaching values of rats without neuropathy. Accordingly, 300 μM 10panx completely prevented the effects of NMDA and BzATP administered 1 h later, on mechanical hyperalgesia and C-reflex wind-up potentiation. Confocal immunofluorescence imaging revealed coexpression of Panx1 with NeuN protein in intrinsic dorsal horn neurons of neuropathic rats. The results indicate that both NMDAR- and P2X7R-mediated increases in mechanical hyperalgesia and C-reflex wind-up potentiation require neuronal Panx1 channel activation to initiate and maintain nociceptive signaling in neuropathic rats.     

P91主蒸汽管道高硬度和低硬度焊缝性能研究

对P91钢的高硬度和低硬度焊缝的冲击功、硬度、断裂韧度和持久强度进行了试验研究,结果表明:硬度高、韧性低的R焊缝具有高的持久强度;硬度低、韧性高的D焊缝具有低的持久强度。材料持久强度的高低与部件的蠕变寿命密切相关。     

110 kV GIS设备在金河水电站的应用

西藏金河水电站采用GIS全封闭组合电器，它改善了恶劣环境对电气设备的危害，提高了供电的可靠性及电站综合自动化水平，有利于运行管理。GIS设备在金河电站的成功应用说明，GIS完全可以在西藏地区推广应用．这也完全符合电力行业的发展趋势。     

High Temperature Oxidation of FGH96 P/M Superalloy

High temperature oxidation behaviors of FGH96 P/M superalloy have been studied in air at temperatures ranging from 600 to 1000℃. By means of isothermal oxidation testing,X-ray diffraction,SEM(scanning electron microscopy),and EDS(energy dispersive X-ray spectroscopy) analyses,the oxidation kinetics as well as the composition and morphology of scales were investigated. Thermodynamic calculations were used to explain the oxidation mechanism. The results showed that as the oxidation temperature increased,the oxidation rate,the scale thickness,and scale spallation increased. FGH96 P/M superalloy exhibits good oxidation resistance at temperature below 800℃. The oxidation kinetics follows an approximately parabolic rate law,and the oxide layer was mainly composed of Cr2O3,TiO2,and a little amount of NiCr2O4. The oxidation is controlled by the transmission of chromium,titanium,and oxygen through the oxide scale.     

便携式SF6气相色谱仪的试验研究及应用

介绍了一种在台式气相色谱仪的基础上,采用高新技术对核心部件热导池进行革新研制出的便携式SF6气相色谱仪。并通过对该气相色谱仪进行实验室试验研究,以及到现场检测SF6绝缘电气设备中的空气、CF4等杂质含量和SF6纯度,证明了该仪器具备同传统的台式色谱仪同等的灵敏度和精度,而且由于具备便携式这一特点,极大地方便了电力检修人员的现场测试,为SF6电气绝缘设备状态检修提供了一种检测手段。     

酸度对P204-HCl-H3AOH体系萃取La(Ⅲ)的机理影响

在pH >1、0204-煤油体系以及P₂₀₄-HCl-H₃AOH 体系负载La有机相进行红外光谱测试,研究了酸度对P₂₀₄-HCl-H₃AOH 体系萃取La(Ⅲ)的机理影响。研究结果表明,当pH>1时,萃取过程的实质是La离子与P-OH 置换,遵循阳离子交换机制;0相似文献   

P91大管氩电联焊工艺试验

P91马氏体钢在大型火力发电厂中得到广泛的应用。针对φ460mm×47.5mm的P91马氏体厚壁大径管接头在全位置状态下焊接进行了工艺性试验。确定了焊接工艺参数和焊后热处理温度,对接头进行了拉伸、弯曲、冲击等性能试验,观察了接头的微观金相组织。结果表明:焊接接头抗拉强度与弯曲试验结果合格,焊接接头所有区域的组织基本为回火马氏体状态,综合机械性能均能够满足国家标准DL/T868-2004和JB/T 8129-2002等规范要求,同时分析了焊接接头各区组织不同的形成原因。     

Self‐Powered Trace Memorization by Conjunction of Contact‐Electrification and Ferroelectricity

Triboelectric nanogenerator (TENG) is a newly invented technology that can effectively harvest ambient mechanical energy from various motions with promising applications in portable electronics, self‐powered sensor networks, etc. Here, by coupling TENG and a thin film of ferroelectric polymer, a new application is designed for TENG as a self‐powered memory system for recording a mechanical displacement/trace. The output voltage produced by the TENG during motion can polarize the dipole moments in the ferroelectric thin film. Later, by applying a displacement current measurement to detect the polarization density in the ferroelectric film, the motion information of the TENG can be directly read. The sliding TENG and the single‐electrode TENG matrix are both utilized for realizing the memorization of the motion trace in one‐dimensional and two‐dimensional space, respectively. Currently, the ferroelectric thin film with a size of 3.1 mm² can record a minimum area changing of 30 mm² and such resolution can still be possibly improved. These results prove that the ferroelectric polymer is an effective memory material to work together with TENG and thereby the fabricated memory system can potentially be used as a self‐powered displacement monitor.     

基于P2P技术的媒体电信网

融合了P2P技术、利用电信运营商业务平台的媒体电信网(MTN)能够提供有服务质量保证、安全诚信的数字媒体业务。与现有客户端/服务器(C/S)和内容分发网络(CDN)架构的数字媒体系统相比,媒体电信网利用P2P技术,充分挖掘了用户终端资源,极大地降低网络和平台建设投资,具有低成本、高扩展性等独特优势。基于P2P技术的媒体电信网可以激活整个数字媒体产业价值链,具有广阔的市场前景。