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101.
Periodontal disease can lead to severe degeneration of periodontium tissue and the global prevalence is continuously increasing with the growth and aging of population. Guided tissue regeneration (GTR) therapy with an occlusive membrane represents a golden standard in the dental clinic. Given the complex anatomy of the natural periodontium comprising alveolar bone, periodontal ligament (PDL) and cementum, GTR membrane/scaffolds with advanced multiphasic design are put forward to potentially repair the entire periodontium and restore its normal function. In principle, the multiphasic GTR membranes/scaffolds aim to coordinate the responses of both hard and soft tissues during the defect-healing process, augment multi-tissue regeneration, and optimize the formation of new periodontal attachment. In the past few decades, a diversity of GTR membranes/scaffolds with biphasic, triphasic, or gradient structures have been developed and demonstrated a substantial success in periodontal regeneration. This review covers the recent advancements in design of multiphasic GTR membranes/scaffolds from the aspects of materials, functional agents, and fabrication procedures, as well as their therapeutic efficacy assessed in vitro and in vivo. Finally, the limitations in current GTR therapy are discussed and future directions on the material design are also included accordingly. 相似文献
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阐述大型合成氨装置脱碳系统的改造情况,分析改造前脱碳系统运行中存在的问题,介绍脱碳系统改造内容及改造后的运行情况,并总结改造后的工艺效果。 相似文献
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Kazuyuki Matsumoto Yasuhiro Miyake Yuzo Umeda Hiroshi Matsushita Hiroaki Matsuda Akinobu Takaki Hiroshi Sadamori Kazuhiro Nouso Takahito Yagi Toshiyoshi Fujiwara Kazuhide Yamamoto 《International journal of molecular sciences》2013,14(10):20877-20889
This study aimed to investigate the associations of the serial changes of serum levels of various growth factors with liver regeneration after hepatectomy in healthy liver donors. Sixteen healthy liver donors who underwent conventional liver resection were included. Serum levels of various growth factors before hepatectomy and on postoperative day (POD) 1, 3, 5 and 7 were measured. Liver volume data calculated by multi-detector computed tomography using workstation. The ratio of remnant liver volume on POD 0 to liver volume before the operation was 51% ± 20%. The ratio of liver volume on POD 14 to liver volume on POD 0 were inversely correlated with remnant liver volume on POD 0 (r = −0.91). The ratio of liver volume on POD 14 to liver volume on POD 0 were significantly correlated with serum hepatocyte growth factor (HGF) levels on POD 1 (r = 0.54), serum leptin levels on POD 1 (r = 0.54), and serum macrophage colony-stimulating factor (M-CSF) levels on POD 5 (r = 0.76) and POD 7 (r = 0.80). These results suggest that early-phase elevation of serum levels of HGF, leptin and M-CSF may be associated with the acceleration of liver regeneration after hepatectomy in humans. 相似文献
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A concept called “concentration swing absorption (CSA)” was present to save CO2 regeneration heat requirement. In this process the initial lean-CO2 solvent is executed to form the so-called initial CO2-rich solvent (ICRS) by absorbing CO2, then ICRS is split into the concentrated CO2-rich solvent (CCRS) phase and the diluted phase (mainly water). And only CCRS is regenerated in the stripper. Regeneration characteristics of CCRS were investigated as the first step study of CSA. Results showed that compared to the direct regeneration of ICRS, concentrating ICRS before regeneration cannot only improve the regeneration performance, but also reduce the regeneration temperature. Despite the increase of solvent viscosity hindering the CO2 molecular diffusion of regeneration, ICRS should be concentrated to become the special CCRS with higher concentration beyond its unique critical concentration range. Moreover, based on the energy analysis of CSA considering the reboiler heat duty and energy required to concentrate ICRS by taking 30 wt% monoethanolamine (MEA) as an example, theoretically the overall CO2 regeneration heat requirement may be decreased considerably to 2739.98 kJ/kg of CO2 by about 34.78% in the future when ICRS was concentrated to 60 wt%. 相似文献
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Jan H. Hagemann Holger Haegele Susanna Müller Hans-Joachim Anders 《International journal of molecular sciences》2013,14(6):11319-11346
Are there common pathways underlying the broad spectrum of tissue pathologies that develop upon injuries and from subsequent tissue remodeling? Here, we explain the pathophysiological impact of a set of evolutionary conserved danger control programs for tissue pathology. These programs date back to the survival benefits of the first multicellular organisms upon traumatic injuries by launching a series of danger control responses, i.e., 1. Haemostasis, or clotting to control bleeding; 2. Host defense, to control pathogen entry and spreading; 3. Re-epithelialisation, to recover barrier functions; and 4. Mesenchymal, to repair to regain tissue stability. Taking kidney pathology as an example, we discuss how clotting, inflammation, epithelial healing, and fibrosis/sclerosis determine the spectrum of kidney pathology, especially when they are insufficiently activated or present in an overshooting and deregulated manner. Understanding the evolutionary benefits of these response programs may refine the search for novel therapeutic targets to limit organ dysfunction in acute injuries and in progressive chronic tissue remodeling. 相似文献
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介绍了氨分解制氢工艺设备的改进.改造氨汽化器,用蒸汽加热液氨替换电加热液氨;用电加热器直接加热氮气,使分子筛加热再生,改造净化系统. 相似文献