Formulation strategy towards minimizing viscosity mediated negative food effect on disintegration and dissolution of immediate release tablets

Food induced viscosity can delay disintegration and subsequent release of API from solid dosage form which may lead to severe reduction in the bioavailability of BCS type III compounds. Formulations of such tablets need to be optimized in view of this postprandial viscosity factor. In this study, three super disintegrants, croscarmellose sodium (CCS), cross-linked polyvinylpolypyrrolidone (CPD), and sodium starch glycolate (SSG) were assessed for their efficiency under simulated fed state. Tablets containing these disintegrants were compressed at 10 and 30?KN, while taking lactose as a soluble filler. In addition to other compendial tests, disintegration force of these formulations was measured by texture analysis. Comparison of parameters derived from force – time curves revealed a direct relation of maximum disintegration force (F_max) and disintegration force development rate (DFDR) with compressional force in fasted state, whereas an inverse relationship of F_max and DFDR with compressional force was observed in fed state. The gelling tendency of disintegrants influenced the rate of release of API in simulated fed and fasted states when compressional force was changed. These observations recommend the evaluation of formulations in simulated fed state, in the development stage, with an objective of minimizing the negative impact of food induced viscosity on disintegration. Use of disintegrants that act without gelling or can counteract the effect of gelling is recommended for tablet formulations with reduced disintegration time (DT) and mean dissolution time (MDT) in fed state, respectively.     

Research Developments and Prospects on Microseismic Source Location in Mines

Microseismic source location is the essential factor in microseismic monitoring technology, and its location precision has a large impact on the performance of the technique. Here, we discuss the problem of low-precision location identification for microseismic events in a mine, as may be obtained using conventional location methods that are based on arrival time. In this paper, microseismic location characteristics in mining are analyzed according to the characteristics of the mine’s microseismic wavefield. We review research progress in mine-related microseismic source location methods in recent years, including the combination of the Geiger method with the linear method, combined microseismic event location method, optimization of relative location method, location method without pre-measured velocity, and location method without arrival time picking. The advantages and disadvantages of these methods are discussed, along with their feasible conditions. The influences of geophone distribution, first arrival time picking, and the velocity model on microseismic source location are analyzed, and measures are proposed to influence these factors. Approaches to solve the problem under study include adopting information fusion, combining and optimizing existing methods, and creating new methods to realize high-precision microseismic source location. Optimization of the velocity structure, along with applications of the time-reversal imaging technique, passive time-reversal mirror, and relative interferometric imaging, are expected to greatly improve microseismic location precision in mines. This paper also discusses the potential application of information fusion and deep learning methods in microseismic source location in mines. These new and innovative location methods for microseismic source location have extensive prospects for development.     

Effective organizational improvisation in information systems development: Insights from the Tencent messaging system development

Organizational improvisation has been increasingly observed in information systems development (ISD), which leads to both positive and negative results. Extant studies have examined how to conduct effective improvisation, but findings are mainly based on variance-based models; a process model is missing. Our study fills this gap by conducting an in-depth case study of the Tencent messaging system development. Our study identifies a four-phase process model featuring, a continuous iteration between improvisational search and build. Our findings make important contributions to organizational improvisation literature in ISD and general management and provide a step-by-step guide for ISD managers to conduct effective improvisation.     

Development and validation of a crisis self‐efficacy index

This study develops a crisis self‐efficacy index to provide a tool for crisis communication researchers and practitioners to understand behavioural aspects of crisis response better. Evaluations of public's crisis self‐efficacy using this index inform strategic message development to protect the public and minimize crisis damages by identifying the public/s most in need of self‐efficacy enhancing interventions. The index also provides practitioners a useful longitudinal index to evaluate progress in crisis preparedness programs and track changes in efficacy. A four‐stage survey index development process using structural equation modelling identifies four underlying constructs of crisis self‐efficacy: action, preventive, achievement and uncertainty management.     

In the Right Place at the Right Time: miRNAs as Key Regulators in Developing Axons

During neuronal circuit formation, axons progressively develop into a presynaptic compartment aided by extracellular signals. Axons display a remarkably high degree of autonomy supported in part by a local translation machinery that permits the subcellular production of proteins required for their development. Here, we review the latest findings showing that microRNAs (miRNAs) are critical regulators of this machinery, orchestrating the spatiotemporal regulation of local translation in response to cues. We first survey the current efforts toward unraveling the axonal miRNA repertoire through miRNA profiling, and we reveal the presence of a putative axonal miRNA signature. We also provide an overview of the molecular underpinnings of miRNA action. Our review of the available experimental evidence delineates two broad paradigms: cue-induced relief of miRNA-mediated inhibition, leading to bursts of protein translation, and cue-induced miRNA activation, which results in reduced protein production. Overall, this review highlights how a decade of intense investigation has led to a new appreciation of miRNAs as key elements of the local translation regulatory network controlling axon development.     

Sustainability Science and Planning: A Crucial Collaboration?

In this age of public skepticism about science, sustainability science offers a way to increase the application of science in planning and policy. This paper explores the relationship between science and society and the emergence of sustainability science. A comparison of the theory and practice of sustainability science and planning reveals the potential for a natural partnership. Based on the analysis, I suggest ways that planning may bridge the gap and build on the opportunity to strengthen its purpose and impact.     

Refurbishment or quality recovery: joint quality and pricing decisions for new product development

Refurbishment and quality recovery, as two important strategies of reverse logistics, have been widely used for consumer durables, especially consumer electronics. This trend is driven by manufacturers’ profit-seeking behaviours and the increasing environmental concerns of society. This study investigates and compares the optimal emergence of these two strategies when product quality is endogenous. Model analyses provide several notable insights. First, we find that the refurbishment strategy dominates the quality recovery strategy when the fraction of the recoverable quality-inducing components in the defective product is low enough. Moreover, when the refurbishment strategy emerges as the optimum, the quality and price of the new product as well as the total realised sales of both new and refurbished products are consistently higher than those with the quality recovery strategy. In addition, when either the refurbishment or quality recovery strategy emerges as the optimum, the overall consumer surplus is also enhanced. Finally, in the model generalisation, we show that a synthetic strategy with which some of the returned defective products are refurbished and others are remanufactured through quality recovery can certainly increase the manufacturers’ profit compared to either one of them when the fraction of the recoverable quality-inducing components in the defective product is moderate.     

Epos – an instrument for the assessment of the ethical position in software development

Digital technology becomes more powerful, intelligent, pervasive and ubiquitous. Ethical aspects of this development have not yet drawn the appropriate attention of researchers and engineers. This paper presents an instrument that aims at measuring the individual ethical position with regard to the design and development of computer software. The development of the Epos tool was based on two data collections. The data of the first survey (n₁ = 147 participants) were used to select items and to determine the factorial structure of the questionnaire. Results show that the Epos instrument reliably assesses peoples’ ethical opinion with respect to five central components: (1) regulation, (2) data privacy, (3) domain specific knowledge, (4) societal responsibility and (5) company responsibility. In the second survey, we determined the stability of the instruments factor structure by assessing a sample of n₂?=?196 participants. A confirmatory factor analysis (CFA) supported the initial factor structure. Next steps and further implications are discussed regarding the final version of the questionnaire.