Inhibition of La-Fe-Co-Si compound corrosion in distilled water by sodium molybdate and disodium hydrogen phosphate

A comparative study of Na2MoO4·2H2O and Na2HPO4·12H2O as inhibitors for magnetic refrigeration material La-Fe-Co-Si compound corrosion in distilled water at room temperature was carried out.Moreover,the inhibiting behavior of the mixture of Na2MoO4·2H2O and Na2HPO4·12H2O was investigated.Potentiodynamic polarization curves and electrochemical impedance spectroscopy (EIS) measurements were applied to study the corrosion behavior of the compound in the absence or presence of different concentrations of these inhibitors under the same experimental conditions.The study revealed that the mixture of 3.0×10–3 kg/L Na2MoO4·2H2O and 5.0×10–3 kg/L Na2HPO4·12H2O was the best inhibitor reaching the value of inhibition efficiency (ε%) up to 93.9%.Polarization curves showed that the studied compounds acted as anodic inhibitors.The potential of zero charge (PZC) of La-Fe-Co-Si compound was determined in distilled water in the absence of the studied inhibitors.Corrosion inhibition mechanisms for inhibitors were proposed in this work.     

滨海地区地下混凝土结构防腐设计

通过了解氯离子对混凝土的腐蚀及破坏机理,介绍滨海地区一工程中地下混凝土结构防腐做法及相关混凝土耐久性设计措施。     

新型三氮唑化合物在H_2SO_4中对Q235钢的缓蚀作用

钢材酸洗时添加缓蚀剂是一种有效、经济的防腐蚀方法,研究缓蚀剂对其作用机理,发展和完善缓蚀剂理论,已成为研究热点.通过失重试验、动电位极化曲线、交流阻抗谱测试及扫描电镜(SEM)方法研究了新型三氮唑化合物1-(4-氟基苯)-3-[4-(1,2,4-三氮唑-1-甲氧基)-苯]-丙烯缓蚀剂(FTPP)在0.5mol/,L H2SO4溶液中对Q235钢的缓蚀作用.结果表明:FTPP对Q235钢的缓蚀效果与自身浓度有关,在0.5mol/L H2SO4中当其达到10-3 mol/,L时,缓蚀率高达92.8%,能同时抑制腐蚀的阴、阳极反应过程,它是一种混合型缓蚀剂;Q235钢的阻抗值随FTPP浓度增加而增大,FTPP在钢表面的吸附符合Langmuir等温式.     

1－十二酰胺基－1－甲基乙膦酸钠及其微乳液的缓蚀作用

用静态失重法、稳态极化曲线和扫描电镜初步研究了ＤＡＭＥＰＮａ＿２－及ＤＡＭＥＰＮａ＿２－庚烷－戊醇－自来水微乳液对２０￣＃碳钢的缓蚀性能，结果表明（１）两者都为抑制阳极为主的混合型缓蚀剂，（２）该微乳液具有较好的缓蚀性能，缓蚀率可达９９％以上，而单一ＤＡＭＥＰＮａ＿２－的缓蚀率仅为１６．２％。     

Pan-Lysyl Oxidase Inhibitor PXS-5505 Ameliorates Multiple-Organ Fibrosis by Inhibiting Collagen Crosslinks in Rodent Models of Systemic Sclerosis

Systemic sclerosis (SSc) is characterised by progressive multiple organ fibrosis leading to morbidity and mortality. Lysyl oxidases play a vital role in the cross-linking of collagens and subsequent build-up of fibrosis in the extracellular matrix. As such, their inhibition provides a novel treatment paradigm for SSc. A novel small molecule pan-lysyl oxidase inhibitor, PXS-5505, currently in clinical development for myelofibrosis treatment was evaluated using in vivo rodent models resembling the fibrotic conditions in SSc. Both lysyl oxidase and lysyl oxidase-like 2 (LOXL2) expression were elevated in the skin and lung of SSc patients. The oral application of PXS-5505 inhibited lysyl oxidase activity in the skin and LOXL2 activity in the lung. PXS-5505 exhibited anti-fibrotic effects in the SSc skin mouse model, reducing dermal thickness and α-smooth muscle actin. Similarly, in the bleomycin-induced mouse lung model, PXS-5505 reduced pulmonary fibrosis toward normal levels, mediated by its ability to normalise collagen/elastin crosslink formation. PXS-5505 also reduced fibrotic extent in models of the ischaemia-reperfusion heart, the unilateral ureteral obstruction kidney, and the CCl4-induced fibrotic liver. PXS-5505 consistently demonstrates potent anti-fibrotic efficacy in multiple models of organ fibrosis relevant to the pathogenesis of SSc, suggesting that it may be efficacious as a novel approach for treating SSc.     

Multiplexed-Based Assessment of DNA Damage Response to Chemotherapies Using Cell Imaging Cytometry

The current methods for measuring the DNA damage response (DDR) are relatively labor-intensive and usually based on Western blotting, flow cytometry, and/or confocal immunofluorescence analyses. They require many cells and are often limited to the assessment of a single or few proteins. Here, we used the Celigo^® image cytometer to evaluate the cell response to DNA-damaging agents based on a panel of biomarkers associated with the main DDR signaling pathways. We investigated the cytostatic or/and the cytotoxic effects of these drugs using simultaneous propidium iodide and calcein-AM staining. We also describe new dedicated multiplexed protocols to investigate the qualitative (phosphorylation) or the quantitative changes of eleven DDR markers (H2AX, DNA-PKcs, ATR, ATM, CHK1, CHK2, 53BP1, NBS1, RAD51, P53, P21). The results of our study clearly show the advantage of using this methodology because the multiplexed-based evaluation of these markers can be performed in a single experiment using the standard 384-well plate format. The analyses of multiple DDR markers together with the cell cycle status provide valuable insights into the mechanism of action of investigational drugs that induce DNA damage in a time- and cost-effective manner due to the low amounts of antibodies and reagents required.     

高分子荧光增白型返黄抑制剂的合成及性能研究

以自由基捕获剂2,2’,6,6’-四甲基哌啶胺(4-氨基哌啶)替代其中一种氨基化合物,用三聚氯氰为交联单体,经过两步缩合反应得到双三嗪氨基二苯乙烯荧光增白型返黄抑制剂单体,再与聚乙二醇系列产品发生缩聚反应合成了新型结构高分子化荧光增白型返黄抑制剂。采用红外和核磁光谱等手段对其分子结构进行了表征,用紫外光谱、荧光光谱分析方法对其光学性质进行了初步研究,并通过紫外光加速老化实验考察了目标产物对化机浆纸张的返黄抑制效果。实验结果表明,在使用性能上,与荧光返黄单体及传统的荧光增白剂VBL相比,合成的高分子荧光增白型返黄抑制剂对纸张增白效果及光抑制效果更好,其结构稳定性、耐光性得到明显改善,同时对其紫外吸收性能及荧光量子产率也有显著的增加。     

溴化锂溶液中苯并三氮唑对碳钢缓蚀作用研究

为降低溴冷机中碳钢的腐蚀,通过失重法和电化学方法研究了含有0.07 mol/L LiOH和150mg/L Na2MoO4的55%LiBr、60%LiBr溶液中苯并三氮唑(BTA)对碳钢的缓蚀作用.结果表明,在溴化锂溶液中添加BTA时可显著降低碳钢腐蚀;55%LiBr、60%LiBr溶液中BTA的最佳添加量为100 mg/L;55%LiBr溶液中,BTA通过与铁离子形成Fe-BTA型配合物覆盖在金属表面阻碍浸蚀性Br-吸附而起缓蚀作用;60%LiBr溶液中,BTA则与MoO42-共同作用,在碳钢表面形成MoO2、MoO3和Fe-BTA致密钝化膜减缓金属活性溶解.     

Early-stage nucleation of manganese sulfide particle and its processing evolution in Fe—3wt.%Si alloys

Manganese sulfide is often referred to as one of important inhibitors in grain-oriented electrical steels, which is of great importance to yield strong Goss texture. However, the early stage of nucleation for such inhibitors and their evolution during the processing has not been well understood. In present work we selected a Fe--3.12wt.%Si--0.11wt.%Mn--0.021wt.%S model system and used FE-SEM and atom probe tomography (APT) to investigate the precipitation behavior of MnS inhibitors at near atomic scale. It was found that the Si--S enriched clusters with sizes of 5--15 nm were formed close to the MnS particles. The density of inhibitors decreased after large pseudo-plane-strain compression because of the effect of dislocation motion, and then slightly increased again when sample was aged at 200°C for 48 h. The dislocations and grain boundaries can act as fast diffusion paths and assist the reemergence of Si--S enriched clusters.