草浆漂白中生物技术的应用

随着生物技术的发展,木聚糖酶在包括漂白在内的制浆造纸工业上的应用日益受到重视。但由于木聚糖酶用于纸浆漂白的机理至今尚不完全清楚,这在一定程度上影响了木聚糖酶在纸浆漂白中的广泛应用。本文对木聚糖酶漂白草浆的作用原理及其应用进行了重点阐述。     

Particle‐Based Synthesis of Peptide Arrays

High‐density peptide arrays with solid amino acid particles: Intermittent “freezing” of activated amino acid derivatives within solid particles allows a laser printer or a chip to spatially address these “postal packages”. Subsequent parallel coupling is started simply by melting a whole layer of 20 different amino acid particles, freeing the hitherto immobilized amino acids and resulting in the coupling of all 20 different amino acids to the support in a single coupling step.

     

Selective Antifolates for Chemically Labeling Proteins in Mammalian Cells

Antifolate labels : Molecules that bind specifically and with high affinity to proteins can be developed into powerful tools for chemical biology. The interaction between substituted 5‐benzyl pyrimidines and dihydrofolate reductase can be exploited for chemically labeling fusion proteins in mammalian cells.

     

In vitro and in vivo Staining Characteristics of Small,Fluorescent, Aβ42‐Binding D‐Enantiomeric Peptides in Transgenic AD Mouse Models

Plaque visualisation : We identified three different D ‐enantiomeric peptides that bind to Alzheimer's amyloid β (Aβ1‐42). As there is currently no definitive pre‐mortem diagnosis for Alzheimer's disease, we investigated the peptides' suitability as molecular probes for in vivo imaging in transgenic mouse models.

     

2003年美国总统绿色化学挑战奖

论述了一年一度的美国总统绿色化学挑战奖,对于绿色化学研究、推动化学化工等领域的安全与环保工作有启发和指导意义。2003年获奖的个人和公司已经揭晓,介绍了他们的绿色化学成就——固体氧化物催化剂合成的无废水工艺(更新合成路线奖)、微生物法生产1,3．丙二醇(改进溶剂和反应条件奖)、EcoWorx(tm)地毯片(设计更安全化学品奖)、温和的选择性脂肪酶催化聚合(绿色化学学术奖)、高效而环境友好的生物杀真菌剂Serenade(r)(小企业奖)等,指出与生物技术相结合是未来化学化工的重要方向。     

生物技术及产业发展趋势

分析了世界生物技术及产业发展的趋势特点 ,归纳了我国现阶段生物技术产业化的重点领域 ,提出了生物技术作为我国实现跨越式发展的重要技术 ,在发展中必须转变观念 ,抢先起步 ,重新整合科技力量 ,推动形成融合机制和坚持园区聚集发展的观点     

Robustness of bioprocess feedback control to biodiversity

The design of control laws for bioprocesses is generally based on simplified single‐species models. Biodiversity is nonetheless inherent in any bioreactor where contamination leads to a mixture of different species or strains. This paper proposes to define and study the robustness to biodiversity of bioprocess control laws: given a control law designed for one species, what happens when additional species are present? is the approach is illustrated with a well‐used control law which regulates substrate concentration using measurement of growth activity. Depending on the properties of the additional species, the control law can lead to the required objective, but also to an undesired monospecies equilibrium point, coexistence, or even a failure point. Finally, for this case, the robustness can be improved by a saturation of the control. Robustness to biodiversity is a difficult issue which should be better understood and accounted for in the control design. © 2017 American Institute of Chemical Engineers AIChE J, 63: 2742–2750, 2017     

分子生物技术在果汁鉴伪中应用的研究现状

为探究传统发酵牦牛酸奶及奶酪中细菌群落结构的多样性,采用Illumina Miseq高通量测序对西藏林芝传统自然发酵牦牛酸奶（sn）和酪乳（nl）样品进行细菌群落结构分析。结果表明,酪乳和酸奶样品总计测得有效序列条数分别为（58 455±1 145）条和（57 068±1 263）条,共产生（63±2）个和（25±3）个操作分类单元（OTUs）。酪乳样品的α多样性指较高,具有较高的细菌群落多样性;酸奶和酪乳样品细菌的优势细菌门均为厚壁菌门（Firmicutes）,其相对丰度分别为（99.80±3.47）%和（50.76±2.13）%;酸奶样品的优势菌属为乳杆菌属（Lactobacillus）（相对丰度为（74.32±1.23）%）,酪乳样品的优势属为乳球菌属（Lactococcus）（相对丰度为（48.44±2.13）%）;酸奶和酪乳样品在属水平的热图分析表明两个样品的细菌群落结构具有差异性和相似性。     

Linking agricultural production and human nutrition

The adequacy of nutritional status in a population depends on an effective food and agricultural sector. The development of agriculture in relation to nutrition has occurred in 3 phases: 1) improving yield to provide adequate energy from food, 2) improving efficiency of production to diversify the sources of nutrients in the food supply, and 3) targeted efforts to improve the nutritional profile of foods that will help lower the risk of disease and promote health. Success in maintaining yield and efficiency while improving the ability of the food supply to provide good nutrition will require a multi‐discipline effort of nutrition, food, plant and animal scientists in order that the most effective strategies are targeted. © 2000 Society of Chemical Industry