通过式固相萃取-高效液相色谱法测定小麦粉及面粉处理剂中的硫脲

目的 建立通过式固相萃取柱净化,高效液相色谱法测定小麦粉及面粉处理剂(FTA)中硫脲的分析方法。方法 试样中的硫脲经乙腈-水溶液(8:2,V/V)提取,通过式固相萃取柱PRiME HLB净化,XBridge Amide色谱柱(4.6 mm×250 mm,5μm)分离,乙腈-水为流动相梯度洗脱,二极管阵列检测器(DAD)检测,外标法定量。结果 该方法在0.05～20μg/mL浓度范围线性关系良好,相关系数(R²)>0.999;检出限(LOD,S/N≥3)为0.15 mg/kg,定量限(LOQ,S/N≥10)为0.5 mg/kg;在空白小麦粉和FTA中进行3个加标水平(LOQ、2LOQ、10LOQ)的加标回收实验,方法的平均回收率在95.5%～103.7%之间,相对标准偏差(RSD)<5.7%。结论 该方法解决了酶式FTA易胶化分散效果差的问题,同时有效去除了小麦粉及FTA中的基质干扰,保护了色谱柱。该方法简单、灵敏、准确,适用于小麦粉及FTA中硫脲的准确定性、定量分析。     

2021年中国大陆食源性疾病暴发监测资料分析

目的 分析2021年中国大陆食源性疾病暴发事件的流行病学特征,为制定预防措施提供依据。方法对我国食源性疾病暴发监测系统收集的2021年食源性疾病暴发数据的流行病学特征进行描述性统计学分析。结果 2021年,30个省（自治区、直辖市）和新疆生产建设兵团（除西藏自治区）共上报食源性疾病暴发事件数5 493起,累计发病32 334人,死亡117人。在病因明确的3 275起事件中,毒蘑菇导致的事件数和死亡人数最多,分别占49.13%(1 609/3 275)和67.86%(76/112);微生物性致病因子导致的发病人数最多,占53.05%(11 585/21 839);在食源性疾病暴发的场所中,家庭的事件数和死亡人数最多,分别占54.00%(2 966/5 493)和92.31%(108/117);餐饮服务场所的发病人数最多,占65.59%(21 208/32 334)。结论 家庭是毒蘑菇死亡事件发生最多的场所;微生物性致病因子是餐馆和学校食堂的主要致病因素。建议各地根据不同类别食源性疾病暴发事件的发生特点,在高发季节、高发地区、重点场所做好监测预警、食品安全监管、健康教育和医疗救治等工作。     

移动IPv6中的服务质量管理架构研究

为提高下一代移动互联网服务质量管理的有效性，提出了移动IPv6中的一种移动代理扁平架构 (MAFS)，该架构基于MPLS和移动代理的概念，引入了服务质量对象选项QOO和扁平化管理的概念，优化了服务质量的管理机制。通过与分层移动代理架构HMAT的比较看出，MAFS减少了分层、移动代理的数量、开销和信令传递的时间，增强了切换发生时的效率和可用性，提供了更为有效的服务质量管理。     

膜厚大于20μm阳极氧化UNICOL着色的探索

针对膜厚大于20μm阳极氧化6063铝合金型材UNICOL着哑黑色时存在颜色发白的问题,进行分析改进,使UNICOL着色后,得到与AA15哑黑色同样的着色品质。     

Oxy210, a Semi-Synthetic Oxysterol,Exerts Anti-Inflammatory Effects in Macrophages via Inhibition of Toll-like Receptor (TLR) 4 and TLR2 Signaling and Modulation of Macrophage Polarization

Inflammatory responses by the innate and adaptive immune systems protect against infections and are essential to health and survival. Many diseases including atherosclerosis, osteoarthritis, rheumatoid arthritis, psoriasis, and obesity involve persistent chronic inflammation. Currently available anti-inflammatory agents, including non-steroidal anti-inflammatory drugs, steroids, and biologics, are often unsafe for chronic use due to adverse effects. The development of effective non-toxic anti-inflammatory agents for chronic use remains an important research arena. We previously reported that oral administration of Oxy210, a semi-synthetic oxysterol, ameliorates non-alcoholic steatohepatitis (NASH) induced by a high-fat diet in APOE*3-Leiden.CETP humanized mouse model of NASH and inhibits expression of hepatic and circulating levels of inflammatory cytokines. Here, we show that Oxy210 also inhibits diet-induced white adipose tissue inflammation in APOE*3-Leiden.CETP mice, evidenced by the inhibition of adipose tissue expression of IL-6, MCP-1, and CD68 macrophage marker. Oxy210 and related analogs exhibit anti-inflammatory effects in macrophages treated with lipopolysaccharide in vitro, mediated through inhibition of toll-like receptor 4 (TLR4), TLR2, and AP-1 signaling, independent of cyclooxygenase enzymes or steroid receptors. The anti-inflammatory effects of Oxy210 are correlated with the inhibition of macrophage polarization. We propose that Oxy210 and its structural analogs may be attractive candidates for future therapeutic development for targeting inflammatory diseases.     

不同成核效果成核剂的应用与研究进展

成核调节剂按其对成核的影响分为成核促进剂和成核抑制剂,介绍了这两类成核剂的特性、研究现状及其对结晶过程及晶体产品质量的影响,且对溶液结晶中的成核剂作用机理进行了简要的论述,旨在使研究者对成核调节剂及成核作用机理有更深的理解,为晶体成核的研究提供理论指导.     

基于分级代理的智能家庭网络模型研究

针对现有家庭网络中智能设备不能有效学习家庭用户习惯,致使不能满足用户的个性化服务质量的问题,给出了一种基于分级代理的智能家庭网络模型.首先给出了一种智能家庭网络设备的形式化描述,以此为基础提出了分级代理的智能家庭网络模型:全局Agent通过对家庭中的长期数据进行学习,总结出一定的服务规则,指导设备Agnet根据家庭成员的生活习惯改变工作方式;设备Agent利用强化学习算法,自主学习,解读家庭环境的状态变化,并做出最优选择.该模型的应用实例及仿真结果表明,应用此模型,设备可以学习用户习惯,为用户提供个性化服务.     

Preparation and characterization of foamed polyurethane/silicone rubber/graphite nanocomposite as radio frequency wave absorbing material: The role of interfacial compatibilization

A novel method for the preparation of radio frequency (RF) wave absorber polyurethane foam (PU) has been developed by impregnation of PU foam in n-hexane solution of room temperature vulcanizing (RTV) silicone rubber (SR) hybridized with graphite nanosheets (GNs) called doping solution. Extent of the GNs dispersion was optimized by the incorporation of a specific type of bifunctional compatibilizer. Insulator to conductive transition threshold as well as electromagnetic wave absorption characteristics of the fabricated nanocomposites was shown to be dependent upon the compatibilizer functionality. All PU/SR/GN nanocomposites generated from bifunctional compatibilizer exhibited higher electrical conductivity with enhanced permittivity implying enhanced formation of conductive networks by GN platelets. Permittivity of the PU/SR/GN nanocomposite based on bifunctional compatibilizer showed to be higher than uncompatibilized counterpart. Electromagnetic reflection loss behavior of the PU/SR/GN nanocomposites exhibited a non-linear correlation with the electrical conductivity. Although all PU/SR/GN prepared nanocomposites exhibited electromagnetic wave reflection loss behavior, but this revealed to be affected by the GN level as well as the size and dispersion state of the graphite nanosheets.     

基于图着色理论的异构车联网时隙分配方案

针对异构车联网系统车辆较多导致时隙分配困难的问题,提出了一种基于图着色理论的时隙分配方案。该方案以考虑两跳内节点的图为模型,通过图着色的方法分配时隙,有效降低了隐藏终端带来的丢包;另外给出了一种高效实用的时隙重用分配算法。该算法根据度定义权值以确定车辆分配时隙数目,保证了公平性,提高了时隙重用,进而提高了消息发送的可靠性,同时也适用于网络拓扑多变的车联网场景。仿真结果表明,在车辆数为200、时隙数为100时,与传统时隙分配方法相比,该方案的车辆平均收包率获得大幅提升。此外,随着时隙重用的增加,车辆间干扰增强,从而导致平均收包率降低。研究还发现,增加车辆发射功率时,由于接收端信干噪比先增加后趋于不变,所以平均收包率也先增加后趋于不变。