250g/L苯醚甲环唑乳油配方研究

以改性大豆为溶剂,筛选出250 g/L苯醚甲环唑乳配方,并测定了其稳定性。结果表明,该乳油性能稳定、乳化性良好。     

苯醚甲环唑水乳剂高效液相色谱分析

[目的]建立高效液相色谱法测定苯醚甲环唑水乳剂中苯醚甲环唑的含量的方法.[方法]分析条件:色谱柱Waters C18 Bondapak 300 mm×4.9 mm;以乙腈-甲醇-水(体积比45:40:15)为流动相;检测波长254 nm;流速0.7 mL/min.[结果]变异系数0.60%,标准偏差为0.061,平均回收率为99.3%.[结论]该方法具有较高的准确度和精密度,并且操作简便、快速,可用于产品质量分析检测.     

苯醚甲环唑残留量的气相色谱分析方法研究

建立了气相色谱法测定香蕉果肉、全果和土壤中苯醚甲环唑残留量的分析方法。实验结果表明：添加量为0．02～2．0mg／kg时．果肉、全果和土壤中的平均回收率分别为：86．88％-98．52％、83．80％-96．01％和94．00％～97．27％．相对标准偏差分别为2．77％～5．74％、3．98％-6．11％和2．76％-5．32％,方法的最小检出量为2．0×10^-12g．最低检出浓度为0．002mg／kg。方法快速、灵敏度高、重现性好,具有较好的准确度和精确度．可用于环境系统中的苯醚甲环唑的残留检测分析。     

新型杀菌剂苯醚甲环唑合成研究

以间二氯苯、乙酰氯等为起始原料,经酰化、醚化、溴化、环化和缩合反应,合成了苯醚甲环唑。关键中间体4-(4氯-苯氧基)-2氯-苯乙酮的粗品含量达到了98.7%,收率高达96.0%;苯醚甲环唑的含量达到97.6%,合成总收率为70%。     

25%苯醚甲环唑水悬浮剂的研制

苯醚甲环唑是一种广谱内吸型杀菌剂,对多种作物的病害有较好防治效果。介绍了农药悬浮剂的实验理论依据,并采用优化组合法对25%苯醚甲环唑水悬浮剂的表面活性剂进行了筛选。试验结果表明,该产品悬浮率90%以上,热贮(54℃±2℃,14d)分解率小于5%,产品各项指标符合悬浮剂的要求。     

恶醚唑防治石榴麻皮病试验效果

用10%恶醚唑水分散颗粒剂50～100mg a.i./L喷雾对石榴麻皮病防治效果90%以上,优质果比例76%～66%,果实售价增加1.4～3.4元/kg.     

苯甲·吡唑酯微乳剂研制及田间防效

介绍了苯甲·吡唑酯微乳剂的配方和制备方法。通过对溶剂、乳化剂、防冻剂、水质的考察,最终确定20%苯甲·吡唑酯微乳剂最优配方为10%苯醚甲环唑、10%吡唑醚菌酯、13%乙酸乙酯、10%环己酮、7%BP、5%农乳500#、3%农乳1602P、6%JFC、3%乙二醇,自来水补足至100%。在此基础上,开发了30%苯甲·吡唑酯微乳剂配方。苯甲·吡唑酯微乳剂各项性能良好,具有良好的开发和应用前景。     

苯醚甲环唑和吡唑醚菌酯在西瓜中的残留分析及膳食风险评价

目的评价苯醚甲环唑和吡唑醚菌酯在西瓜中的长期慢性和短期急性膳食摄入风险。方法于2018年进行1年10地规范残留试验,建立检测西瓜中苯醚甲环唑和吡唑醚菌酯残留的分析方法。样品经乙腈提取,加NaCl盐析,经无水MgSO4除水和PSA净化,用超高效液相色谱串联质谱法(ultra performance liquid chromatography tandem mass spectrometry, UPLC-MS/MS)分析,采用多反应离子监测模式(MRM)检测,正离子(ESI+)化,基质匹配外标法定量。结果目标物在一定质量浓度范围内具有良好的线性关系(r≥0.9991)。西瓜在0.01、0.05、0.5 mg/kg添加水平下,苯醚甲环唑平均回收率为92%~103%,相对标准偏差为0.9%~8.9%之间;吡唑醚菌酯的平均回收率为92%~95%, RSDs为1.7%~10.3%,定量限为0.01 mg/kg。膳食评估的结果:一般人群苯醚甲环唑的国家估算每日摄入量(the national estimated daily intake, NEID)为8.57μg/kg·bw/d,占日允许摄入量的85.7%;一般人群吡唑醚菌酯的NEID为18.72μg/kg·bw/d,占日允许摄入量的62.4%。短期急性膳食风险评苯醚甲环唑短期膳食摄入量(the national estimated short-term daily intake, NESTI)为2.98~4.26μg/kg·bw/d,占急性参考剂量(the acute reference dose, ARfD)的0.99%~1.42%,吡唑醚菌酯NESTI为6.23~8.90μg/kg·bw/d,占ARfD的12.46%~17.8%。我国规定的水果中苯醚甲环唑和吡唑醚菌酯最高MRL分别为2 mg/kg和4 mg/kg,该值对我国各类人群在水果中苯醚甲环唑暴露保护水平为1.44~11.24倍;吡唑醚菌酯暴露保护水平为2.16~16.86倍。结论苯醚甲环唑和吡唑醚菌酯长期慢性和短期急性膳食摄入风险较低,现有水果MRL对各类人群的暴露量在可接受的范围之内。     

防治梨黑星病田间药效试验

为筛选出防治梨黑星病的有效药剂，2002年以宝珠梨为对象，对梨黑星病进行田间防治试验，结果表明：10％恶醚唑3000倍液、40％氟硅唑3000倍液和50％醚菌酯4000倍液对梨黑星病防效分别为88％、83％和81％。生产上建议于梨树花前、花后及进入雨季后施药进行防冶。     

Cellulose-Based Hectocycle Nanopolymers: Synthesis,Molecular Docking and Adsorption of Difenoconazole from Aqueous Medium

The goal of this work was to develop polymer-based heterocycle for water purification from toxic pesticides such as difenoconazole. The polymer chosen for this purpose was cellulose nanocrystalline (CNC); two cellulose based heterocycles were prepared by crosslinking with 2,6-pyridine dicarbonyl dichloride (Cell-X), and derivatizing with 2-furan carbonyl chloride (Cell-D). The synthesized cellulose-based heterocycles were characterized by SEM, proton NMR, TGA and FT-IR spectroscopy. To optimize adsorption conditions, the effect of various variable such as time, adsorbent dose, pH, temperature, and difenoconazole initial concentration were evaluated. Results showed that, the maximum difenoconazole removal percentage was about 94.7%, and 96.6% for Cell-X and Cell-D, respectively. Kinetic and thermodynamic studies on the adsorption process showed that the adsorption of difenoconazole by the two polymers is a pseudo-second order and follows the Langmuir isotherm model. The obtained values of ∆G ° and ∆H suggest that the adsorption process is spontaneous at room temperature. The results showed that Cell-X could be a promising adsorbent on a commercial scale for difenoconazole. The several adsorption sites present in Cell-X in addition to the semi crown ether structure explains the high efficiency it has for difenoconazole, and could be used for other toxic pesticides. Monte Carlo (MC) and Molecular Dynamic (MD) simulation were performed on a model of Cell-X and difenoconazole, and the results showed strong interaction.