静电层层自组装法整理多巴胺改性涤/棉混纺织物的阻燃性能

为了赋予涤/棉混纺织物良好的阻燃性能,以pH值为5、质量分数为1%壳聚糖溶液和pH值为2、质量分数为1.5%植酸钠溶液,通过静电层层自组装法,对经多巴胺改性后的涤/棉(65/35)混纺织物进行阻燃整理。其中正负离子交替沉积1次记为组装1层,第1层内每次组装15 min,第1层后各次组装时间为5 min,共组装15层。探讨了整理后织物极限氧指数(LOI)、炭长、热重、热释放速率、炭渣形貌等性能。结果表明:多巴胺改性可以提高涤/棉混纺织物的反应性,有利于阻燃整理;整理后织物阻燃性能显著提高,LOI值从未整理时的18.8%提高到28.7%;热分解温度比未整理织物大幅提前,炭渣含量较未整理提高了5.7%;整理后织物点燃时间延长,平均热释放速率(HRR)和峰值热释放速率(PHRR)分别为14.16 k W/m2和51.07 k W/m2,相较未整理涤/棉织物下降了84.62%和78.47%,织物燃烧危险性显著降低。     

Sila-haloperidol, a silicon analogue of the dopamine (D2) receptor antagonist haloperidol: synthesis, pharmacological properties, and metabolic fate

Haloperidol (1 a), a dopamine (D(2)) receptor antagonist, is in clinical use as an antipsychotic agent. Carbon/silicon exchange (sila-substitution) at the 4-position of the piperidine ring of 1 a (R(3)COH --> R(3)SiOH) leads to sila-haloperidol (1 b). Sila-haloperidol was synthesized in a new multistep synthesis, starting from tetramethoxysilane and taking advantage of the properties of the 2,4,6-trimethoxyphenyl unit as a unique protecting group for silicon. The pharmacological profiles of the C/Si analogues 1 a and 1 b were studied in competitive receptor binding assays at D(1)-D(5), sigma(1), and sigma(2) receptors. Sila-haloperidol (1 b) exhibits significantly different receptor subtype selectivities from haloperidol (1 a) at both receptor families. The C/Si analogues 1 a and 1 b were also studied for 1) their physicochemical properties (log D, pK(a), solubility in HBSS buffer (pH 7.4)), 2) their permeability in a human Caco-2 model, 3) their pharmacokinetic profiles in human and rat liver microsomes, and 4) their inhibition of the five major cytochrome P450 isoforms. In addition, the major in vitro metabolites of sila-haloperidol (1 b) in human liver microsomes were identified using mass-spectrometric techniques. Due to the special chemical properties of silicon, the metabolic fates of the C/Si analogues 1 a and 1 b are totally different.     

基于多巴胺及其衍生物的传感器在食品快速检测中的研究进展

食品安全问题关系国计民生,快速检测技术对实现食品安全战略具有重要意义。聚多巴胺及其复合材料修饰的传感器在食品快速检测中表现出良好的稳定性,且具有检测限低、灵敏度高的优势;此外,聚多巴胺及其修饰复合材料制备过程简单、绿色环保,基于这些优点,聚多巴胺及其复合材料在食品安全评价、环境监测、生物分析等领域的运用备受关注。本文综述了基于多巴胺及其衍生物的光学、电化学传感器在食品检测方面的一些设计和应用,以体现其明显的应用优越性。最后,对多巴胺及其衍生物在食品快速检测领域面临的挑战和未来的发展前景进行探讨,以期对多巴胺在食品快速检测新技术方面的推广应用提供参考。     

聚ABSA修饰电极对多巴胺、抗坏血酸、尿酸的同时测定

采用电聚合的方法制备了聚对氨基苯磺酸修饰电极（pABSA/GCE）,并采用循环伏安法和线性扫描方法分别对多巴胺（DA）,抗坏血酸（AA）,尿酸（UA）以及三者的混合液进行了测定,研究了该修饰电极的电化学行为。结果表明,pABSA/GCE对AA,DA,UA有良好的电催化作用。在混合液的测定中,三者可以很好的分离,AA-DA、DA-UA、AA-UA的峰电位差分别为265 mV,146 mV和411 mV。该pABSA/GCE修饰电极既用于混合液中AA、DA和UA的分别测定也可以用于三者的同时测定,电极重现性和稳定性良好。     

手性拓扑电荷指数和构效关系研究

对拓扑电荷指数进行了扩展,得到了含电负性的手性拓扑电荷指数。将其与Julián-Qrtiz 等人对该指数的扩展结果相比较,结果表明,新的拓扑指数能够得到更好的QSAR 模型。进一步运用人工神经网络法构造了数学模型,该模型能够更好地预测手性化合物的活性。     

Dopamine‐Modified Cationic Conjugated Polymer as a New Platform for pH Sensing and Autophagy Imaging

A dopamine‐modified conjugated polymer PFPDA is synthesized and characterized. At low pH, dopamine exists in its hydroquinone form and lacks the ability to quench fluorescence. At high pH, the proportion of the quinone form of dopamine increases due to its autooxidation, and efficient intramolecular electron transfer from the polymer main chain to quinone occurs, resulting in the quenching of the fluorescence of PFPDA. Thus, PFPDA exhibits a fluorescence “turn‐on” response at low pH. PFPDA possesses excellent photostability and exhibits no cytotoxicity, which makes it a good fluorescent material for pH sensing and cell imaging. A light‐induced hydroxyl anion emitter, MGCB, is also used to change the pH of the solution and thus regulate the fluorescence of PFPDA via remote control under light irradiation. Because the cytoplasm becomes acidic when cell autophagy occurs, PFPDA can also be used for autophagy imaging of HeLa cells with good selectivity.     

碳纳米管表面修饰/有机氟改性聚氨酯-丙烯酸酯的制备与性能

以多巴胺(DOA)在弱碱性体系下氧化自聚反应和γ-氨丙基三乙氧基硅烷(APTES)水解缩合反应协同修饰碳纳米管(CNTs)，获得了A-DOA/CNTs材料；再以异佛尔酮二异氰酸酯(IPDI)、聚碳酸酯多元醇(PCDL)、二羟甲基丁酸(DMBA)、季戊四醇三丙烯酸酯(PETA)合成了双键半封端的聚氨酯预聚体，利用体系中剩余的异氰酸酯基与修饰后CNTs表面活性基团发生共价缩聚并交联，最终与有机氟等乙烯基类单体进行乳液共聚反应，制备出A-DOA/CNTs改性FPUA复合乳液。经检测得出结论如下：当A-DOA/CNTs用量为0.75%时，有机氟单体用量为12%时，A-DOA/CNTs/FPUA复合胶膜在热失重为10%时，热分解温度为329℃，相比PUA胶膜热分解温度为292℃时提高了37℃，此时，复合胶膜在-55℃时的动态储能模量E′为最大值，玻璃化温度Tg为83℃，显著改善了胶膜的热稳定性，此时，A-DOA/CNTs/FPUA胶膜的吸水率为5.2%，水接触角为103.1?，其拉伸强度为23.3MPa，断裂伸长率为352%，综合性能为最佳。     

液质法测定动物源性食品中肾上腺素、多巴胺

为同时测定动物源性食品中肾上腺素、多巴胺的含量,建立HPLC-MS-MS检测方法。该两种物质的线性范围均为3～1500μg/kg。低、中、高三种浓度加标回收率均为90%～101%;检出限分别为肾上腺素1μg/kg、多巴胺3μg/kg。本方法快速简便,灵敏度高,选择性好,测定结果令人满意,可在各食品检测机构推广应用。     

Characterization of the role of medial prefrontal cortex dopamine receptors in cocaine-induced locomotor activity.

Medial prefrontal cortex (mPFC) dopamine (DA) modulates the motor-stimulant response to cocaine. The present study examined the specific mPFC DA receptor subtypes that mediate this behavioral response. Intra-mPFC injection of the DA D?-like receptor agonist quinpirole blocked cocaine-induced motor activity, an effect that was prevented by coadministration of the D2 receptor antagonist sulpiride. Intra-mPFC injection of the selective D? receptor agonist PD 168,077 or the selective D? receptor agonist SKF 81297 did not alter the motor-stimulant response to cocaine. Finally, it was found that an intermediate dose of quinpirole, which only attenuated cocaine-induced motor activity, was not altered by SKF 81297 coadministration, suggesting a lack of synergy between mPFC D?, and D? receptors. These results suggest that D? receptor mechanisms in the mPFC are at least partly responsible for mediating the acute motor-stimulant effects of cocaine. (PsycINFO Database Record (c) 2010 APA, all rights reserved)