装饰设计专业《计算机辅助设计》辅助教学网站的建设研究

装饰艺术设计专业《计算机辅助设计》课程的教学,既要能学会熟练操作各类艺术设计软件,又要有装饰制图知识、艺术设计能力和独创性思维能力。而各类辅助设计软件彼此之间缺少必要的联系和连贯性,学生很难系统掌握。因此建设本课程的辅助教学网站很有必要,使传统课堂讲授和网络教学相结合。本文同时还从网站建设思路和建设方案等方面来探讨本课程的网站辅助教学方法。     

Site occupations and ordering behaviour of O phase in Ti2AlNb—based intermetallics

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智能化磁控谐振高压试验系统研究

目前电网智能化水平的提升对高压试验的智能化和试验效率也有了更高的需求,为解决现有的高压试验电源在高压交流绝缘试验中存在的不足,提升高压试验的效率,提出了一种智能化磁控谐振高压试验系统。该试验系统集升压、补偿和调谐于一体,具有升压调节平滑连续,结构紧凑等优势,可用于工频耐压试验。阐述了该系统的结构组成与基本原理,并搭建了该试验系统仿真模型,通过研究空载和负载运行特性验证了该系统原理的正确性。     

The GAUGAA Motif Is Responsible for the Binding between circSMARCA5 and SRSF1 and Related Downstream Effects on Glioblastoma Multiforme Cell Migration and Angiogenic Potential

Circular RNAs (circRNAs) are a large class of RNAs with regulatory functions within cells. We recently showed that circSMARCA5 is a tumor suppressor in glioblastoma multiforme (GBM) and acts as a decoy for Serine and Arginine Rich Splicing Factor 1 (SRSF1) through six predicted binding sites (BSs). Here we characterized RNA motifs functionally involved in the interaction between circSMARCA5 and SRSF1. Three different circSMARCA5 molecules (Mut1, Mut2, Mut3), each mutated in two predicted SRSF1 BSs at once, were obtained through PCR-based replacement of wild-type (WT) BS sequences and cloned in three independent pcDNA3 vectors. Mut1 significantly decreased its capability to interact with SRSF1 as compared to WT, based on the RNA immunoprecipitation assay. In silico analysis through the “Find Individual Motif Occurrences” (FIMO) algorithm showed GAUGAA as an experimentally validated SRSF1 binding motif significantly overrepresented within both predicted SRSF1 BSs mutated in Mut1 (q-value = 0.0011). U87MG and CAS-1, transfected with Mut1, significantly increased their migration with respect to controls transfected with WT, as revealed by the cell exclusion zone assay. Immortalized human brain microvascular endothelial cells (IM-HBMEC) exposed to conditioned medium (CM) harvested from U87MG and CAS-1 transfected with Mut1 significantly sprouted more than those treated with CM harvested from U87MG and CAS-1 transfected with WT, as shown by the tube formation assay. qRT-PCR showed that the intracellular pro- to anti-angiogenic Vascular Endothelial Growth Factor A (VEGFA) mRNA isoform ratio and the amount of total VEGFA mRNA secreted in CM significantly increased in Mut1-transfected CAS-1 as compared to controls transfected with WT. Our data suggest that GAUGAA is the RNA motif responsible for the interaction between circSMARCA5 and SRSF1 as well as for the circSMARCA5-mediated control of GBM cell migration and angiogenic potential.     

基于水质模拟的水质在线监测站点布设研究

随着水质监测连续化的需求增加,河流水质在线监测站布设成为不可忽视的问题。本文采用水文模拟模型HSPF对台湾淡水河流域进行水量水质联合模拟。水文模拟以9个测站比对,纳什效率系数多数大于0.7;相关系数r皆大于0.7。水质模拟以27个测站比对,生化需氧量、氨氮、悬浮固体、溶氧的修正平均百分误差多数小于25%。基于水质变化率和水质超标率提出水质敏感河段概念,并以此确定为补充布设水质在线监测站点的优先河段。研究指出,淡水河流域水质在线监测站目前仍缺乏且位置不尽合理,应优先补充三峡河的三峡大桥、景美溪的宝桥、基隆河的江北桥水质在线监测站。     

基于RHT模型双孔同时爆破均质岩体损伤的数值模拟

为探究双孔爆破时炮孔间距和额外自由面对爆破过程中爆破损伤的影响,基于RHT（Riedel-Hiermaier-Thoma）损伤本构建立了多组三维数值模型,利用模型损伤云图研究不同爆破条件下的岩石爆破过程,通过自定义变量—有效损伤率的变化探究炮孔周围岩石损伤的时空演化过程。结果表明：随着炮孔间距的增加,岩石有效损伤率逐渐递减,相同截面处的有效损伤率在炮孔间距最小的方案中最大,相邻炮孔间的爆破能量叠加作用随炮孔间距的增大而减弱,合适的炮孔间距可以获得更加理想的爆破效果;岩石有效损伤率随着自由面到炮孔中心处距离的增大而逐渐减小,爆破能量倾向于向自由面方向传播,额外自由面对爆破能量分布的影响随自由面与炮孔间距的增大而减弱。数值模拟结果对研究双孔爆破能量的传递法则具有一定的借鉴意义。     

全层状TiAl合金层片生长及其影响因素

利用光学显微镜(OM)和TEM，研究了全层状TiAl合金的层片间距的影响因素及与各因素的关系。实验结果表明，全层状TiAl合金的层片间距与冷却速度和合金中铝含量有关，层片间距与冷却速度呈反比关系，并随着合金中铝含量的增加而增加。同时，以层片生长的台阶机制为基础，推导出了全层状TiAl合金在连续冷却过程中层片间距的数学表达式，推导结果与实验结果相符。     

用攀枝花钛矿和云南钛矿冶炼钛渣工业试验研究

通过磁性测量和X-射线衍射研究了Gd2(Co，Al)17化合物的结构和磁晶各向异性。当x≤4时，样品具有菱方Th2znl7型结构，x=5时，具有六方CaCu5型结构。随着Al浓度增加，晶格常数和单胞体积单调增大，而居里温度和自发磁化强度近似线性地减小；在x≥l时，观察到Co亚点阵的磁晶各向异性变号，室温易磁化方向由易面转变为易轴，且易轴各向异性场和各向异性常数随Al原子浓度增加出现极大值；基于补偿温度(65K)下自由粉末颗粒的磁化曲线，导出了亚点阵间的分子场系数和Gd-co交换耦合常数，结果表明，Al原子对Gd-Co交换耦合作用的影响较小。根据Al原子在Co亚点阵4种晶位的择优占位，分析了磁晶各向异性的演变。     

Effect of lamellar spacing on microstructural instability and creep behavior of a lamellar TiAl alloy

Finer lamellar spacing in the lamellar structure of a Ti–45Al–2Nb–2Mn + 0.8 vol.%TiB₂ (45XD) alloy does improve the primary creep resistance. However, the unstable nature of the fine plate contributes largely to the degradation of the lamellar structure and a rapid increase in the tertiary creep rate, indicating that a fine lamellar structure has a detrimental effect on the long-term creep.     

凝固速率对定向凝固合金DZ22枝晶臂间距和枝晶偏析的影响

采用新研制的超高梯度定向凝固装置，研究了不同凝固速率下定向凝固高温合金ＤＺ２２枝晶臂间距和枝晶偏析。结果表明，冷运速率增大，枝晶臂间距显著细化，枝晶偏析被强烈抑制。当冷运速率为５２．４Ｋ．ｓ＾－１时，一次、二次枝晶臂间距λ１和λ２分别为２８．８和８．４μｍ，Ｎｂ，Ｔｉ，Ａｌ，Ｃｒ，Ｃｏ，Ｗ等元素的偏析比均趋近于１。