Red Wine Polyphenols for Cancer Prevention

Conventional cancer therapies, the second leading cause of death worldwide, result in serious side effects and, at best, merely extend the patient''s lifespan by a few years. Searching for effective prevention is of high priority in both basic and clinical sciences. In recent decades natural products have been considered to be an important source of cancer chemopreventive agents. Red wine polyphenols, which consisted of various powerful antioxidants such as flavonoids and stilbenes, have been implicated in cancer prevention and that promote human health without recognizable side effects. Since resveratrol, a major component of red wine polyphenols, has been studied and reviewed extensively for its chemopreventive activity to interfere with the multi-stage carcinogenesis, this review focuses on recent progress in studies on cancer chemopreventive activities of red wine polyphenol extracts and fractions as well as other red wine polyphenols, like procyanidin B5 analogues and myricetin.     

An integrated biodesulfurization process,including inoculum preparation,desulfurization and sulfate removal in a single step,for removing sulfur from oils

BACKGROUND: A single‐stage reactor, in which the growth of bacterial culture, induction of desulfurizing enzymes, and desulfurization reaction are carried out in a single step, was adopted to investigate desulfurization of dibenzothiophene (DBT) at high cell densities. Rhodococcus erythropolis, IGTS8 was used as the biocatalyst. Optimal conditions for bacterial growth and DBT desulfurization were investigated. RESULTS: Optimization of fermentation conditions was necessary to obtain high cell densities including controlling accumulation of acetate. Under optimal operating conditions, the maximum optical density at 600 nm (OD₆₀₀) was measured to be 26.6 at 118 h of cultivation. When biodesulfurization of DBT in model oil with a high cell density culture of IGTS8 was investigated, accumulation of sulfate was found to limit the extent of desulfurization. A sulfate removal step was added to obtain a single‐stage integrated biodesulfurization process. Sulfate removal was achieved via an aqueous bleed stream and use of a separation unit to recycle the organic phase. CONCLUSION: A proof of principle of a complete system capable of biocatalyst growth, induction, desulfurization and by‐product separation was demonstrated. This system enables simplification of the biodesulfurization process and has potential to lower the operating cost of the bioprocess. Copyright © 2008 Society of Chemical Industry     

Spline-regression estimation of the influence of exposure dose on cancer probability

Spline regression is used to analyze the influence of radiation on the cancer probability in a group of participants of Chernobyl accident mitigation, depending on the exposure dose. A new method is proposed to approximate modified polygons by linear splines with two nodes. An algorithm for the identification of a transition point is outlined. __________ Translated from Kibernetika i Sistemnyi Analiz, No. 3, pp. 168–176, May–June 2006.     

新器件条件下对行输出级电路计算公式的修正与补充(Ⅵ)

当彩色显示器使用初级线圈电感量L_P较小的新逆程变压器时,流过饱和导通行输出管的集电极电流I_(CP),不但包括偏转线圈L_Y中的正向锯齿波电流I_(YCP),还有不能忽略的FBT初级线圈中的正向锯齿电流I_(FCP),即CGA卡时峰值电流I_(CP)(6.1A)=I_(YCP)(3.9A)+I_(FCP)(2.2A)。因此有必要对行输出级电路的电流计算公式作相应的修正和补充。     

Patterns of Fos-like immunoreactivity in the brains of parent ring doves (Streptopelia risoria) given tactile and nontactile exposure to their young.

Neuronal activation was examined by fos immunohistochemistry in ring doves (Streptopelia risoria) reunited with their young after overnight separation. In an initial study, squab-exposed parents showed more fos immunoreactivity (ir) in the preoptic area (POA) and lateral hypothalamus (LH) than squab-deprived parents. In a 2nd study, parents allowed free access to young and those separated from young by a wire mesh partition showed more fos-ir in the POA, LH, and lateral septum than box-exposed controls. Contact with young also increased fos-ir in the medial preoptic nucleus and bed nucleus of the stria terminalis, but noncontact exposure did not. Conversely, nontactile squab exposure stimulated more fos-ir in the POA than did free access to young, which suggests POA involvement in appetitive aspects of parenting. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

浅谈施工阶段的工程造价管理

就施工单位如何把工程造价的发生控制在合理的范围和核定的造价限额以内，从工程承包实行招投标制、缩短工期、重视现场签证和索赔工作等方面进行了阐述，以达到节约投资，提高经济效益目的。     

基于改进BP神经网络的网络故障诊断研究

针对网络故障诊断过程中故障规则难以提取的问题,提出一种基于改进BP神经网络的故障诊断方法。以网络故障信息为样本对BP网络进行训练,利用其强大的自适应能力和非线性映射能力,建立起网络故障信息与故障模式输出之间的映射。同时,为了避免BP网络的学习算法陷入局部极小值,提高故障诊断的效率和精确度,采用L-M优化算法来对网络进行训练。另外,采取初期终止的方法提高BP网络的泛化能力。实例表明,该方法有效提高了网络故障诊断的有效性。     

重症监护病房紧急状况预警算法

重症监护病房中的病人身体状况通常很不稳定,常出现各种需要医护人员介入治疗的紧急状况。由于医疗资源有限,医护人员可能无法及时发现并处理这些紧急状况,给病人的存活率带来严重的负面影响。如果可以预测这些紧急状况的发生,并及时通知相关医护人员,将大大提高病人的存活率。常见重症监护病房紧急状况包括突然死亡、败血症、肺部感染、急性低血压、以及器官衰竭等。紧急状况预警建模主要采用病人的长时间生命体征监测数据,预测在一定时间之后发生某种紧急状况的可能性。预警模型所采用的监测数据分为静态数据、事件数据和时间序列数据等三类。静态数据具有容易采集、但预测准确性偏低的特点。事件数据或时间序列数据、以及多种类型数据的混合数据对于紧急状况预警模型的预测性能的提高有重要作用,将会获得更广泛的应用。     

SCS模型在山区小流域山洪灾害预报预警中的适用性分析

预报预警是山洪灾害防治中重要的非工程措施,是防灾减灾救灾的关键环节。选取分别代表秦巴山地水资源保护区、西南地震作用区、喀斯特地区、黄土高原超渗产流区、东南沿海台风影响区的湖北省丹江口官山河流域、四川省都江堰白沙河流域、贵州省望谟县望谟河流域、陕西省子洲县岔巴沟流域、广东省高州市马贵河流域这5个典型流域,通过构建改进的SCS模型进行历史山洪模拟,探讨该模型在小流域暴雨山洪预报预警中的广泛适用性。结果表明:基于SCS模型构建的小流域暴雨山洪预报方案中官山河、白沙河、望谟河、马贵河方案均为乙级方案,可用于正式发布预报;岔巴沟为丙级方案,可用于参考性预报。SCS模型在5个典型示范区的洪峰流量预报精度普遍在80%左右,高于我国山洪灾害洪峰流量预报平均水平(40%)。总体来说,SCS模型对各类典型流域的山洪模拟效果较好,能够用于山洪灾害预报预警业务。SCS模型结构简单,参数少,特别适用于无资料地区推广应用。     

小浪底细砂岩单轴压缩声发射特征研究

采用岩石伺服试验机和声发射仪,对小浪底三叠系细砂岩进行单轴压缩声发射试验。基于试验结果,将试样变形过程划分为压密、弹性、塑性和破坏四个阶段,分析了不同阶段试样声发射幅值、峰值频率、振铃计数和能量的变化特征,在此基础上对比分析了试样声发射ｂ值以及累计振铃计数的演化规律,得出了岩石的破坏时间前兆特征。研究结果表明:压密和弹性阶段试样声发射幅值、振铃计数和能量处于较低水平、峰值频率频带数量依次增多;塑性阶段试样幅值增大、振铃计数与能量上升且整体处于较高水平、峰值频率数值增大且呈现多频带化,临近破坏阶段试样产生大量100ｄＢ的高幅值信号,振铃计数与能量持续急增,峰值频率降低,频带减少;声发射ｂ值的变化规律可以间接反映岩体内部微裂隙萌生、扩展的演化特征。