Integrated data analysis on the electron temperature profile of HL-2A with the Bayesian probability inference method

Data analysis on tokamak plasmas is mainly based on various diagnostic systems, which are usually modularized and independent of each other. This leads to a large amount of data not being fully and effectively exploited so that it is not conducive to revealing the deep physical mechanism. In this work, Bayesian probability inference with machine learning methods have been applied to the electron cyclotron emission and Thomson scattering diagnostic systems on HL-2A/2M, and the effects of integrated data analysis (IDA) on the electron temperature of HL-2A with Bayesian probability inference are demonstrated. A program is developed to infer the whole electron temperature profile with a confidence interval, and the program can be applied in online analysis. The IDA results show that the full profile of the electron temperature can be obtained and the diagnostic information is more comprehensive and abundant with IDA. The inference models for electron temperature analysis are established and the developed programs will serve as an experimental data analysis tool for HL-2A/2M in the near future.     

基于多体动力学的汽轮机振动声辐射机理及传递路径

采用多体动力学方法进行汽轮机机械振动激励源精确分析,在激励源分析结果的基础上研究低频激励下的机组振动响应,并采用声传递向量（Acoustic Transfer Vector,ATV）方法研究汽轮机组表面与外场辐射的声压传递贡献量,从多体动力学的角度并结合流固耦合的方法综合分析汽轮机组振动噪声产生机理并研究噪声典型传递路径。研究结果表明,旋转激励源为汽轮机组的主要振动激励源,在低频段汽轮机组辐射模式为单极子,在中高频段汽轮机组辐射模式为偶极子。由噪声辐射的指向性极坐标图可知,在不同高度处噪声指向性相似,并都在长度方向上取得噪声声压级较大值,具有较强的指向性。计算方法对汽轮机组减振降噪研究具有一定的指导意义。     

电位滴定法测定重过磷酸钙中游离P2O5含量

介绍用电位滴定法测定重过磷酸钙中游离P2O5含量的方法。采用设定终点滴定,终点pH值为4.5,开始条件设置滴定前搅拌60s,最大滴定速度0.01mL/min,最小滴定速度0.005mL/min,终点前动态范围pH1.000,终点停止漂移0.02mL/min,测量点时间间隔2.0s,滴定方向选择pH值升高的方向,停止体积为成品重钙10.00mL、鲜钙20.00mL。该方法简便,快速,准确度、精密度高。     

AH36钢两相区非平衡凝固路径的数值预测

应用多元合金两相区凝固显微偏析数学模型,对AH36钢在一定冷却条件下的非平衡凝固路径进行了数值计算,获得了相应的局部固相分数与局部温度之间的变化关系,为该钢种对应的连铸浇铸过程仿真及其它凝固过程仿真提供了必要而准确的耦合数据,具有重要的理论意义和广泛的适用性.     

Myoglobin/gold nanoparticles/carbon spheres 3-D architecture for the fabrication of a novel biosensor

A novel biosensor based on a myoglobin/gold nanoparticles/carbon spheres (Mb-AuNPs-CNs) 3-D architecture bioconjunction has been fabricated for the determination of hydrogen peroxide (H₂O₂). Cyclic voltammetry (CV), Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) were used to characterize the bioconjunction of the AuNPs-CNs with Mb. Experimental results demonstrate that the AuNPs-CNs hybrid material is more effective in facilitating electron transfer of the immobilized enzyme than CNs alone, which can be attributed to the unique nanostructure and larger surface area of the bioconjunction. The biosensor displayed good performance for the detection of H₂O₂ with a wide linear range from 0.28 μmol/L to 116.5 μmol/L and a detection limit of 0.12 μmol/L. The Michaelis-Menten constant K _M^app value was estimated to be 0.3 mmol/L. The resulting biosensor exhibited fast amperometric response, and good stability, reproducibility, and selectivity to H₂O₂. This article is published with open access at Springerlink.com     

有机硅膜分离润滑油中脱蜡溶剂的机理研究

利用气相色谱法,在348．15～368．15K温度,测定了正己烷、正庚烷、正癸烷、甲苯和丁酮溶剂在有机硅膜中的无限稀释扩散系数,结合Vrentas-Duda自由体积模型计算得到溶剂／有机硅膜体系溶剂有限浓度扩散系数,在理论上预测了不同溶剂在有机硅膜中扩散特性对膜分离性能的影响,在实验和理论两个方面,为进一步研究有机硅膜分离机理打下了基础．     

A_Ⅰ型多元固溶体价电子结构的计算

利用“固体与分子经验电子理论”提出:1)A(?)型多元置换、间隙式固溶体价电子结构计算的模型;z)末知键距结构的键距差(BLD)分析方法;3)BLD分析中解的不唯一性的处理。     

Order vs. Disorder: Cholesterol and Omega-3 Phospholipids Determine Biomembrane Organization

Lipid structural diversity strongly affects biomembrane chemico-physical and structural properties in addition to membrane-associated events. At high concentrations, cholesterol increases membrane order and rigidity, while polyunsaturated lipids are reported to increase disorder and flexibility. How these different tendencies balance in composite bilayers is still controversial. In this study, electron paramagnetic resonance spectroscopy, small angle neutron scattering, and neutron reflectivity were used to investigate the structural properties of cholesterol-containing lipid bilayers in the fluid state with increasing amounts of polyunsaturated omega-3 lipids. Either the hybrid 1-stearoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine or the symmetric 1,2-docosahexaenoyl-sn-glycero-3-phosphocholine were added to the mixture of the naturally abundant 1-palmitoyl-2-oleyl-sn-glycero-3-phosphocholine and cholesterol. Our results indicate that the hybrid and the symmetric omega-3 phospholipids affect the microscopic organization of lipid bilayers differently. Cholesterol does not segregate from polyunsaturated phospholipids and, through interactions with them, is able to suppress the formation of non-lamellar structures induced by the symmetric polyunsaturated lipid. However, this order/disorder balance leads to a bilayer whose structural organization cannot be ascribed to either a liquid ordered or to a canonical liquid disordered phase, in that it displays a very loose packing of the intermediate segments of lipid chains.     

Structural Abnormalities of the Optic Nerve and Retina in Huntington’s Disease Pre-Clinical and Clinical Settings

Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin protein. HD-related pathological remodelling has been reported in HD mouse models and HD carriers. In this study, we studied structural abnormalities in the optic nerve by employing Spectral Domain Optical Coherence Tomography (SD-OCT) in pre-symptomatic HD carriers of Caucasian origin. Transmission Electron Microscopy (TEM) was used to investigate ultrastructural changes in the optic nerve of the well-established R6/2 mouse model at the symptomatic stage of the disease. We found that pre-symptomatic HD carriers displayed a significant reduction in the retinal nerve fibre layer (RNFL) thickness, including specific quadrants: superior, inferior and temporal, but not nasal. There were no other significant irregularities in the GCC layer, at the macula level and in the optic disc morphology. The ultrastructural analysis of the optic nerve in R6/2 mice revealed a significant thinning of the myelin sheaths, with a lamellar separation of the myelin, and a presence of myelonoid bodies. We also found a significant reduction in the thickness of myelin sheaths in peripheral nerves within the choroids area. Those ultrastructural abnormalities were also observed in HD photoreceptor cells that contained severely damaged membrane disks, with evident vacuolisation and swelling. Moreover, the outer segment of retinal layers showed a progressive disintegration. Our study explored structural changes of the optic nerve in pre- and clinical settings and opens new avenues for the potential development of biomarkers that would be of great interest in HD gene therapies.