Photoresponsive Protein–Graphene–Protein Hybrid Capsules with Dual Targeted Heat‐Triggered Drug Delivery Approach for Enhanced Tumor Therapy

A novel photo‐responsive protein–graphene–protein (PGP) capsule that doubles as a photothermal agent with core/shell structure is constructed by anchoring reduced graphene oxide nanosheets on one‐component protein (lactoferrin) shell through a double emulsion method. PGP capsules can transport fully concealed hydrophilic anticancer cargo, doxorubicin (Dox), with a large payload (9.43 μmol g^‐1) to be later unloaded in a burst‐like manner by photo‐actuation triggered by near‐infrared irradiation. Being biocompatible yet with a high cancer cell targeting efficiency, PGP capsules have successfully eradicated subcutaneous tumors in 10 d following a single 5 min NIR irradiation without distal damage. Besides, the photochemothermal therapy of PGP capsules eradicates tumor cells not only in the light‐treating area but also widely light‐omitted tumor cells, overcoming the tumor recurrence due to efficient cell killing efficacy. These results demonstrate that the PGP capsule is a potential new drug delivery platform for local‐targeting, on‐demand, photoresponsive, combined chemotherapy/hyperthermia for tumor treatment and other biomedical applications.     

适合批量生产的GaAs数字IC背面金属化工艺

当前,IC逐步向高集成度、高密度、多功能方向发展,管芯尺寸也在增大;剪切力是器件考核的基本项目,随管芯面积的增大而增大,这就对背面金属化可靠性提出了较高的要求.本文通过分析、实验、分析改进的方法,提出了适合批量生产又兼顾成本因素的数字背面金属化工艺,使背面金属化性能满足了器件可靠性要求.     

大功率扬声器与功率有关的若干问题

在大功率扬声器设计中音圈线径设计是关键。从介绍音圈线径与功率的关系开始,谈到最大振幅(位移)及各注意要点,最后介绍了大功率扬声器用胶粘剂的一些使用问题。     

Synergy of Pickering Emulsion and Sol‐Gel Process for the Construction of an Efficient,Recyclable Enzyme Cascade System

An efficient, easily recyclable enzyme cascade system based on nanoparticle‐stabilized capsules (NPSCs) is constructed through a synergy of a Pickering emulsion and sol‐gel process. Specifically, oligodopa‐coated titania nanoparticles (biomimetic titania) containing the first enzyme (FateDH) are synthesized through a bioadhesion‐assisted biomimetic mineralization approach. The biomimetic titania is then spontaneously assembled at the interface between the oil phase (hexadecane/butyl titanate (BuTi) mixture) and water phase during the formation of Pickering emulsions. The sol‐gel process of BuTi can produce not only butanol for assisting the formation of Pickering emulsions but also titania gel particles (sol‐gel titania) for cross‐linking the biomimetic titania through catechol‐titanium chelating. The NPSCs obtained, which contain the first enzyme, conjugate the second enzyme (FaldDH) onto the surface for constructing the enzyme cascade system. The system exhibits high activity and stability, particularly, superior recyclability for conversion of CO₂ into formaldehyde. In detail, the system shows a formaldehyde yield of 50.0%, and can quickly float onto the air/water interface soon after stopping the agitation of reaction mixtures, which ensures that the formaldehyde yield keeps almost unaltered after 10 times recycling. This study will be useful for facile construction of a wealth of catalytic systems with efficient, recyclable attributes.     

Conductive adhesive with transient liquid‐phase sintering technology for high‐power device applications

A highly reliable conductive adhesive obtained by transient liquid‐phase sintering (TLPS) technologies is studied for use in high‐power device packaging. TLPS involves the low‐temperature reaction of a low‐melting metal or alloy with a high‐melting metal or alloy to form a reacted metal matrix. For a TLPS material (consisting of Ag‐coated Cu, a Sn96.5‐Ag3.0‐Cu0.5 solder, and a volatile fluxing resin) used herein, the melting temperature of the metal matrix exceeds the bonding temperature. After bonding of the TLPS material, a unique melting peak of TLPS is observed at 356 °C, consistent with the transient behavior of Ag₃Sn + Cu₆Sn₅ → liquid + Cu₃Sn reported by the National Institute of Standards and Technology. The TLPS material shows superior thermal conductivity as compared with other commercially available Ag pastes under the same specimen preparation conditions. In conclusion, the TLPS material can be a promising candidate for a highly reliable conductive adhesive in power device packaging because remelting of the SAC305 solder, which is widely used in conventional power modules, is not observed.     

基于工控机和VC的点阵布胶

介绍一种采用螺杆泵式点胶器的接触式布胶试验装置,论述了装置的系统组成及功能,针对系统中的关键组成部分—z轴的运行模式进行了深入的分析和研究;通过VC++6.0设计的用户界面,设定有关参数以控制x、y运动平台、z轴的运动和挤胶过程,达到了应用的要求。     

Self‐Hydrophobization in a Dynamic Hydrogel for Creating Nonspecific Repeatable Underwater Adhesion

Adhesive hydrogels are widely applied for biological and medical purposes; however, they are generally unable to adhere to tissues under wet/underwater conditions. Herein, described is a class of novel dynamic hydrogels that shows repeatable and long‐term stable underwater adhesion to various substrates including wet biological tissues. The hydrogels have Fe³⁺‐induced hydrophobic surfaces, which are dynamic and can undergo a self‐hydrophobization process to achieve strong underwater adhesion to a diverse range of dried/wet substrates without the need for additional processes or reagents. It is also demonstrated that the hydrogels can directly adhere to biological tissues in the presence of under sweat, blood, or body fluid exposure, and that the adhesion is compatible with in vivo dynamic movements. This study provides a novel strategy for fabricating underwater adhesive hydrogels for many applications, such as soft robots, wearable devices, tissue adhesives, and wound dressings.     

功率型白光LED平面涂层技术研究

基于水溶性感光胶的白光LED表面涂层技术,阐述了含有荧光粉感光胶悬浮液的配比和封装结构对白光LED出光效率的影响,提出了相应的改进措施,通过实验证实提高了白光LED器件的整体性能.同时,对利用该法得到的功率型白光LED进行了光衰减测试,LED在700mA电流下点亮168 h后,光输出为初始光输出的95.95%,满足实用要求.     

乳化炸药油水相流量控制

以乳化炸药生产线油、水相流量控制系统为研究对象,分析油、水相流量添加过程的滞后性,针对传统PID控制理论的不足,详细分析了自校正PID理论,采用自校正PID控制策略来实现流量的实时控制。现场运行情况表明,这种控制策略符合工业实际,采用的控制器稳定可靠。