ZL205A高强度铝铜合金的铸造及热处理

探讨了ＺＬＮ２０５Ａ高强度铝铜合金的铸造性能和热处理工艺方法，阐述了ＺＬ２０５Ａ铝铜合金在Ｔ５热处理时，如何才能达到机械性能的工艺方法。     

高强灌浆材料结合卡箍在导管架受损构件加固中的应用

以南海某海域一施工船与四桩导管架基础发生碰撞为背景,结合当前研究对导管架受损区域的承载力进行分析,计算得到受损截面凹陷处的轴向承载力和极限弯矩。简述海洋工程领域中受损构件的加固修复方法,探讨卡箍技术的理论研究现状及其在实际工程中的应用现状。基于典型灌浆卡箍修复技术提出一种采用80 MPa高强度灌浆材料结合卡箍技术进行加固修复的新方案,并采用有限元软件对加固后的组合结构进行数值模拟。仿真结果表明,该组合结构可有效改善导管架受损区域受力状况,提高结构的承载力。简述该方案的施工流程,以期为实际工程提供参考。     

深水海上风机吸力桶导管架基础承载特性

针对海洋深水环境,设计适应70 m水深的四桶导管架结构形式,并在此基础上设计相同高度和主腿斜度的三桶导管架基础。采用Abaqus有限元软件建立导管架结构-吸力桶-土体整体有限元模型,通过对比分析探究海上风电深水吸力桶导管架基础的承载力特性。研究发现：吸力桶与土体的位移一致性程度可反映基础水平极限承载力大小,四桶导管架基础的综合承载特性优于三桶导管架基础;加载高度对四桶导管架基础的水平承载力特性有重要影响,基础水平承载力随着加载高度增加逐渐减小;加载方向对四桶导管架基础水平承载力影响较小。     

基于AHP-模糊综合评价的海上风机基础状态评估

为掌握服役时期的海上风机基础状态并对海上风机基础状态进行评估,提出一套结合故障树分析（Fault Tree Analysis,FTA）法、层次分析（Analytic Hierarchy Process,AHP）法和模糊综合评价法的海上风机基础状态评价模型。针对导管架式海上风机基础,考虑海洋腐蚀和海底冲刷,通过p-y曲线法模拟桩-土相互作用,在风浪流载荷的作用下进行动力响应分析,采用故障树对其失效模式进行分析,确定评价指标,构造判断矩阵计算指标权重,运用模糊综合评价法对各指标和整体进行评价。该模型结合各评价方法的优点,使评价结果更有说服力,可为海上风电场运行维护管理提供技术参考。     

受水流冲刷影响后的吸力桶基础水平极限承载力

以某海域海上风机吸力桶基础为研究对象,采用Abaqus有限元数值模拟软件,考虑基础在不同土层中由水流冲刷导致其周围土体缺失时吸力桶基础的水平承载力。结果表明,桶内土体的缺失对吸力桶水平承载力的影响不大,随着吸力桶基础外周围土体缺失的扩大,其水平承载力逐渐降低,并影响海上风机的正常使用。     

西南桦木包装材料在热处理后的润湿性能研究

通过动态接触角测量、红外光谱分析、表面粗糙度测量、扫描电镜观察和偏相关分析,研究了西南桦木的润湿性能。结果表明,木材经180℃热处理4 h后,润湿性能下降:接触角由40°增至121°,羟基和羰基数量减少,粗糙度降低;处理时间与接触角显著相关;西南桦木用作包装材料,若采用热处理,可去除有害生物,还具备疏水功能。     

C/C复合材料表面硬度对抗氧化性能的影响EI北大核心CSCD

C/C复合材料使用后由于氧化表面硬度有不同程度的下降。经再次防氧化处理后,测试了表面硬度及抗氧化性能。结果表明:氧化后C/C复合材料试样的表面肖氏硬度为HS70时,再次防氧化处理后,其表面硬度增至HS80,在700℃恒温静态氧化条件下,氧化失重率分别为0.44%/15h,1.2%/22h,其抗氧化性能最强。表面硬度为HS40的C/C复合材料试样,距表层1mm深度范围内其硬度均低于基底,再次防氧化处理后其硬度值从HS40增至HS60,其700℃抗氧化性能最差,氧化失重率分别为3.93%/15h,6.52%/22h。     

Effect of postmolding heat treatment on in vitro properties of a polyanhydride implant containing gentamicin sulfate

A polyanhydride implant containing gentamicin sulfate was fabricated using a laboratory-scale injection-molding machine. After injection molding, the implants were subject to heat treatment at 60°C for various time periods with or without nitrogen protection. The impact of this heat treatment on the in vitro properties of the implants including copolymer molecular weights, mechanical properties, and in vitro drug-release profiles was investigated. This heat treatment caused a drastic drop in the molecular weight of the copolymer. Heating without nitrogen protection resulted in the hardening of the implant, but heating in the presence of nitrogen rendered the implant less rigid. It was also found that a faster in vitro drug release profile was shown by implants heated without nitrogen protection and a pronounced slowing down in drug release was exhibited by implants heated with nitrogen protection.     

Near-Complete Remission of Glioblastoma in a Patient Treated with an Allogenic Dendritic Cell-Based Vaccine: The Role of Tumor-Specific CD4+T-Cell Cytokine Secretion Pattern in Predicting Response and Recurrence

Immunotherapy has brought hope to the fight against glioblastoma, but its efficacy remains unclear. We present the case of CST, a 25-year-old female patient with a large right-hemisphere glioblastoma treated with a dendritic–tumor cell fusion vaccine. CST showed a near-complete tumor response, with a marked improvement in her functional status and simultaneous increases in tumor-specific CD8+ and CD4+ T cells. Two months before recurrence, the frequency of tumor-specific T cells decreased, while that of IL-17 and CD4+ T cells increased. CST passed away 15 months after enrollment. In this illustrative case, the tumor-specific CD4+ T-cell numbers and phenotype behaved as treatment efficacy biomarkers, highlighting the key role of the latter in glioblastoma immunotherapy.     

Exogenous dsRNA Induces RNA Interference of a Chalcone Synthase Gene in Arabidopsis thaliana

Recent investigations have shown the possibility of artificial induction of RNA interference (RNAi) via plant foliar treatments with naked double-stranded RNA (dsRNA) to silence essential genes in plant fungal pathogens or to target viral RNAs. Furthermore, several studies have documented the downregulation of plant endogenous genes via external application of naked gene-specific dsRNAs and siRNAs to the plant surfaces. However, there are limited studies on the dsRNA processing and gene silencing mechanisms after external dsRNA application. Such studies would assist in the development of innovative tools for crop improvement and plant functional studies. In this study, we used exogenous gene-specific dsRNA to downregulate the gene of chalcone synthase (CHS), the key enzyme in the flavonoid/anthocyanin biosynthesis pathway, in Arabidopsis. The nonspecific NPTII-dsRNA encoding the nonrelated neomycin phosphotransferase II bacterial gene was used to treat plants in order to verify that any observed effects and processing of AtCHS mRNA were sequence specific. Using high-throughput small RNA (sRNA) sequencing, we obtained six sRNA-seq libraries for plants treated with water, AtCHS-dsRNA, or NPTII-dsRNA. After plant foliar treatments, we detected the emergence of a large number of AtCHS- and NPTII-encoding sRNAs, while there were no such sRNAs after control water treatment. Thus, the exogenous AtCHS-dsRNAs were processed into siRNAs and induced RNAi-mediated AtCHS gene silencing. The analysis showed that gene-specific sRNAs mapped to the AtCHS and NPTII genes unevenly with peak read counts at particular positions, involving primarily the sense strand, and documented a gradual decrease in read counts from 17-nt to 30-nt sRNAs. Results of the present study highlight a significant potential of exogenous dsRNAs as a promising strategy to induce RNAi-based downregulation of plant gene targets for plant management and gene functional studies.