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31.
Feifei Chen Guanghui Wang Chuan Shi Yichen Zhang Long Zhang Wei Li Feng Yang 《应用聚合物科学杂志》2013,127(4):2809-2815
The glycolysis of poly(ethylene terephthalate) (PET) was carried out using excess ethylene glycol (EG) in the presence of zinc acetate as catalysts under microwave irradiation. The effects of particle size, microwave power, the weight ratio of EG to PET, the weight ratio of catalyst to PET, reaction temperature and stirring speed on the yield of bis(hydroxyethyl terephthalate)(BHET) were investigated. The experimental results indicated that the glycolysis rate was significantly influenced by stirring speed and initial particle size. The optimal parameters of glycolysis reactions were the weight ratio of catalyst to PET of 1%, the weight ratio of EG to PET of 5, 500 W and 196°C, the yield of BHET reached to 78% at only 35 min. The glycolysis products were analyzed and identified by FTIR, differential scanning calorimetry, and elemental analysis. The kinetics of glycolysis of PET under microwave irradiation could be interpreted by the shrinking core model of the film diffusion control. The apparent activation energy was evaluated using the Arrhenius equation and it was found to be 36.5 KJ/mol, which was lower compared to the same process using conventional heating. The experimental results also showed that the reaction time was significantly decreased under microwave irradiation as compared with it by conventional heating. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013 相似文献
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33.
Na Mao Honghao Yang Jie Yin Yaqian Li Fuyu Jin Tian Li Xinyu Yang Ying Sun Heliang Liu Hong Xu Fang Yang 《International journal of molecular sciences》2021,22(18)
Glycolytic reprogramming is an important metabolic feature in the development of pulmonary fibrosis. However, the specific mechanism of glycolysis in silicosis is still not clear. In this study, silicotic models and silica-induced macrophage were used to elucidate the mechanism of glycolysis induced by silica. Expression levels of the key enzymes in glycolysis and macrophage activation indicators were analyzed by Western blot, qRT-PCR, IHC, and IF analyses, and by using a lactate assay kit. We found that silica promotes the expression of the key glycolysis enzymes HK2, PKM2, LDHA, and macrophage activation factors iNOS, TNF-α, Arg-1, IL-10, and MCP1 in silicotic rats and silica-induced NR8383 macrophages. The enhancement of glycolysis and macrophage activation induced by silica was reduced by Ac-SDKP or siRNA-Ldha treatment. This study suggests that Ac-SDKP treatment can inhibit glycolytic reprogramming in silica-induced lung macrophages and silicosis. 相似文献
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35.
氨纶废丝的醇解产物分析 总被引:5,自引:0,他引:5
以二甘醇为醇解剂,以二月桂酸二丁基锡为催化剂对氨纶废丝进行了醇解,醇解产物冷冻后分成两层,上层为白色蜡状醇解产物、下层为棕色液体。对白色蜡状醇解产物进行了红外光谱、核磁共振测试,对棕色液体进行了高效液相色谱—质谱联用测试。结果表明:白色蜡状醇解产物主要为聚醚多元醇;棕色液体除了过量的二甘醇以外,主要含有二甘醇-异氰酸酯加成化合物。 相似文献
36.
Glycolysis temperature, glycolysis time, and amount of catalyst are important factors affecting the glycolysis of recycled poly(ethylene terephthalate) (PET) flakes. A 23 factorial experimental design is applied to study the main, two‐factor interaction, and three‐factor interaction effects of glycolysis temperature, glycolysis time, and amount of catalyst on the glycolysis of recycled PET flakes. In this study cobalt acetate is used as the glycolysis catalyst. The sequence of the main effects on the glycolysis conversion of the recycled PET flakes in ascending order is glycolysis time < glycolysis temperature < amount of catalyst. The sequence of the two‐factor interaction effects on the glycolysis conversion of the recycled PET flakes in ascending order is glycolysis temperature versus the glycolysis time < glycolysis time versus the amount of catalyst < glycolysis temperature versus the amount of catalyst. The three‐factor interaction effect is significantly related to the glycolysis conversion of the recycled PET flakes. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 80: 956–962, 2001 相似文献
37.
Yosuke Inomata Jae-Won Oh Kohei Taniguchi Nobuhiko Sugito Nao Kawaguchi Fumitoshi Hirokawa Sang-Woong Lee Yukihiro Akao Shinji Takai Kwang-Pyo Kim Kazuhisa Uchiyama 《International journal of molecular sciences》2022,23(9)
Non-alcoholic steatohepatitis (NASH) has pathological characteristics similar to those of alcoholic hepatitis, despite the absence of a drinking history. The greatest threat associated with NASH is its progression to cirrhosis and hepatocellular carcinoma. The pathophysiology of NASH is not fully understood to date. In this study, we investigated the pathophysiology of NASH from the perspective of glycolysis and the Warburg effect, with a particular focus on microRNA regulation in liver-specific macrophages, also known as Kupffer cells. We established NASH rat and mouse models and evaluated various parameters including the liver-to-body weight ratio, blood indexes, and histopathology. A quantitative phosphoproteomic analysis of the NASH rat model livers revealed the activation of glycolysis. Western blotting and immunohistochemistry results indicated that the expression of pyruvate kinase muscle 2 (PKM2), a rate-limiting enzyme of glycolysis, was upregulated in the liver tissues of both NASH models. Moreover, increases in PKM2 and p-PKM2 were observed in the early phase of NASH. These observations were partially induced by the downregulation of microRNA122-5p (miR-122-5p) and occurred particularly in the Kupffer cells. Our results suggest that the activation of glycolysis in Kupffer cells during NASH was partially induced by the upregulation of PKM2 via miR-122-5p suppression. 相似文献
38.
Frances L. Byrne Ellen M. Olzomer Nina Lolies Kyle L. Hoehn Marthe-Susanna Wegner 《International journal of molecular sciences》2022,23(9)
Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer. Low numbers of HCC patients being suitable for liver resection or transplantation and multidrug resistance development during pharmacotherapy leads to high death rates for HCC patients. Understanding the molecular mechanisms of HCC etiology may contribute to the development of novel therapeutic strategies for prevention and treatment of HCC. UDP-glucose ceramide glycosyltransferase (UGCG), a key enzyme in glycosphingolipid metabolism, generates glucosylceramide (GlcCer), which is the precursor for all glycosphingolipids (GSLs). Since UGCG gene expression is altered in 0.8% of HCC tumors, GSLs may play a role in cellular processes in liver cancer cells. Here, we discuss the current literature about GSLs and their abundance in normal liver cells, Gaucher disease and HCC. Furthermore, we review the involvement of UGCG/GlcCer in multidrug resistance development, globosides as a potential prognostic marker for HCC, gangliosides as a potential liver cancer stem cell marker, and the role of sulfatides in tumor metastasis. Only a limited number of molecular mechanisms executed by GSLs in HCC are known, which we summarize here briefly. Overall, the role GSLs play in HCC progression and their ability to serve as biomarkers or prognostic indicators for HCC, requires further investigation. 相似文献
39.
Satoshi Kubota Kazumi Kawata Takako Hattori Takashi Nishida 《International journal of molecular sciences》2022,23(11)
Cellular communication network factor (CCN) 2 and 3 are the members of the CCN family that conduct the harmonized development of a variety of tissues and organs under interaction with multiple biomolecules in the microenvironment. Despite their striking structural similarities, these two members show contrastive molecular functions as well as temporospatial emergence in living tissues. Typically, CCN2 promotes cell growth, whereas CCN3 restrains it. Where CCN2 is produced, CCN3 disappears. Nevertheless, these two proteins collaborate together to execute their mission in a yin–yang fashion. The apparent functional counteractions of CCN2 and CCN3 can be ascribed to their direct molecular interaction and interference over the cofactors that are shared by the two. Recent studies have revealed the mutual negative regulation systems between CCN2 and CCN3. Moreover, the simultaneous and bidirectional regulatory system of CCN2 and CCN3 is also being clarified. It is of particular note that these regulations were found to be closely associated with glycolysis, a fundamental procedure of energy metabolism. Here, the molecular interplay and metabolic gene regulation that enable the yin–yang collaboration of CCN2 and CCN3 typically found in cartilage development/regeneration and fibrosis are described. 相似文献
40.
Lan Wang Kai Xu Ningdan Wang Linke Ding Wenyu Zhao Ruyan Wan Weiming Zhao Xiaoshu Guo Xin Pan Juntang Yang Ivan Rosas Guoying Yu 《International journal of molecular sciences》2022,23(22)
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fatal interstitial lung disease with unknown etiology. Despite substantial progress in understanding the pathogenesis of pulmonary fibrosis and drug development, there is still no cure for this devastating disease. Fenbendazole (FBZ) is a benzimidazole compound that is widely used as an anthelmintic agent and recent studies have expanded the scope of its pharmacological effects and application prospect. This study demonstrated that FBZ treatment blunted bleomycin-induced lung fibrosis in mice. In vitro studies showed that FBZ inhibited the proliferation and migration of human embryo lung fibroblasts. Further studies showed that FBZ significantly inhibited glucose consumption, moderated glycolytic metabolism in fibroblasts, thus activated adenosine monophosphate-activated protein kinase (AMPK), and reduced the activation of the mammalian target of rapamycin (mTOR) pathway, thereby inhibiting transforming growth factor-β (TGF-β1)-induced fibroblast-to-myofibroblast differentiation and collagen synthesis. In summary, our data suggested that FBZ has potential as a novel treatment for pulmonary fibrosis. 相似文献