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化香虫茶总黄酮对CCl_4诱导小鼠肝损伤的预防效果 总被引:1,自引:0,他引:1
本文对虫茶总黄酮的肝损伤预防效果进行了研究。虫茶黄酮可以使CCl4诱导的肝损伤小鼠血清中的谷草转氨酶(AST)、谷丙转氨酶(ALT)、乳酸脱氢酶(LDH)、丙二醛(MDA)和甘油三酯(TG)含量下降,升高血清中的还原型谷胱甘肽(GSH)含量。同时,虫茶黄酮还可以使肝损伤小鼠肝脏中的MDA和TG含量下降,GSH含量上升,且100mg/kg浓度虫茶黄酮的效果更显著,能够接近常用的肝病治疗药物水飞蓟。对小鼠血清中细胞因子的检测也发现灌胃虫茶黄酮小鼠的IL-6、IL-1β、TNF-α和IFN-γ水平低于对照组小鼠,接近正常组和药物水飞蓟组。组织病理切片证明虫茶黄酮可以减轻CCl4对肝组织的破坏,保护肝脏细胞。虫茶黄酮灌胃小鼠相对于对照组小鼠肝脏组织中的炎症相关基因NF-κB被下调,IκB-α被上调。结果表明虫茶黄酮有较好的肝损伤预防效果。 相似文献
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立筒仓粮堆在储藏期间感染害虫和不正常升温,是安全储粮的难题,本试验在立筒仓内安装了一套共用管道系统,兼有熏蒸杀虫,通风降温和熏蒸残余气体利用的功能。使用该系统进行环流熏蒸,仓内各部位熏蒸气体分布均匀,杀虫效果达到100%,还配备了带有加热装置的气化器,在大气温度低于15.6℃和用药量超过51b的情况下,可使液态熏蒸剂充分气化,而达到理想的杀虫效果。该系统通风降温效果好,通风后每米粮层温差<1℃。将两个立筒仓的共用管道串接,可将熏蒸仓内约40%的熏蒸气体输送至邻仓,解决了残留药剂的利用问题。该试验安装的共用管道系统具有设计合理、设备简单的特点。 相似文献
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Oksana Panasiuk 《Journal of chemical ecology》1984,10(9):1325-1333
The responses of Colorado potato beetle,Leptinotarsa decemlineata (Say), to volatile components of tansy,Tanacetum vulgare L., were investigated in order to establish a chemical basis for observed reduction in beetle populations when potatoes,Solanum tuberosum L., were interplanted with tansy. Colorado potato beetles exhibited avoidance behavior to tansy oil, volatiles from intact tansy plants, a hydrocarbon fraction of tansy oil, obtained by fractionation on alumina, and five of the 13 known components of tansy oil that were tested. One constituent of tansy oil, -pinene, attracted beetles. 相似文献
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R. F. N. Hutchins O. R. W. Sutherland C. Gnanasunderam W. J. Greenfield E. M. Williams H. J. Wright 《Journal of chemical ecology》1984,10(1):81-93
Crude extracts of root of the forage legumesLotus pedunculatus andCoronilla varia (crownvetch) were toxic when administered orally to 3rd instarCostelytra zealandica larvae. A group of 3-nitropropanoyl-d-glucopyranoses was isolated from active fractions of the crude extracts. These toxins, some of which were already known fromC. varia, have not previously been reported fromL. pedunculatus. The compounds were present in root tissue of this species at a concentration of about 1% dry weight. They include the triester karakin and the diesters coronarian and cibarian, all of which were toxic to larvae ofC. zealandica at levels which could account fully for the activity of the crude extracts. 相似文献
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Michael S. Koch John M. DeSesso Amy Lavin Williams Suzanne Michalek Bruce Hammond 《Critical reviews in food science and nutrition》2016,56(3):512-526
To determine the reliability of food safety studies carried out in rodents with genetically modified (GM) crops, a Food Safety Study Reliability Tool (FSSRTool) was adapted from the European Centre for the Validation of Alternative Methods’ (ECVAM) ToxRTool. Reliability was defined as the inherent quality of the study with regard to use of standardized testing methodology, full documentation of experimental procedures and results, and the plausibility of the findings. Codex guidelines for GM crop safety evaluations indicate toxicology studies are not needed when comparability of the GM crop to its conventional counterpart has been demonstrated. This guidance notwithstanding, animal feeding studies have routinely been conducted with GM crops, but their conclusions on safety are not always consistent. To accurately evaluate potential risks from GM crops, risk assessors need clearly interpretable results from reliable studies. The development of the FSSRTool, which provides the user with a means of assessing the reliability of a toxicology study to inform risk assessment, is discussed. Its application to the body of literature on GM crop food safety studies demonstrates that reliable studies report no toxicologically relevant differences between rodents fed GM crops or their non-GM comparators. 相似文献