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挡土墙填土曲线破裂面的地震主动土压力分析 总被引:2,自引:0,他引:2
在地震作用影响下,墙后填土处于极限平衡状态时,假定破裂面为一条通过墙趾的旋轮线。从墙后土楔中取出一微薄水平层,研究其在水平惯性力下的平衡,得到的地震土压力分布和土压力合力作用点位置均与实验结果相吻合。 相似文献
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In this paper the modelling, analysis and optimization of millimeter wave oscillatorsare investigated by using the a frequency-domain harmonic balance technique (FDHB), where theexternal-circuit impedances looking outside from the active device are calculated with a combinedtechnique of modes expansion, Galerkin, and collocation methods. The optimization results arein agreement with the experimental ones, which show the reliability of the presented model andoptimization. 相似文献
27.
Structure-activity studies of human tumour necrosis factors 总被引:3,自引:0,他引:3
Van Ostade Xaveer; Tavernier Jan; Fiers Walter 《Protein engineering, design & selection : PEDS》1994,7(1):5-12
The mechanism by which tumour necrosis factors (TNF and lymphotoxin,also called TNFß and TNFß respectively) exerttheir cytotoxic activity on many malignant cells, remains largelyunknown. Furthermore, the broad array of differentiation (geneinduction) and mitogenic activities towards many primary cellsis still a subject of intensive investigation. TNF is an importantmediator in inflammation, immune responses and infection-relatedphenomena and these activities contribute to the severe toxidtyseen when TNF is used as an anticancer agent. The first stepin the mechanism of action is the specific binding of the ligandto its receptors and dissection of the molecular mechanism involvedin this interaction is the subject of this review. The reasonsfor the interest in this aspect are obvious: first, the developmentof strong antagonistic TNF analogues can be useful in dampeningthe potentially lethal or debilitating effects of an overproductionof the cytokine (as in septic shock or rheumatoid arthritis).Secondly, since two distinct TNF receptors exist, constructionof TNF muteins that distinguish between both types may leadto derivatives of this plekrtropic agent with a more restrictedbiological activity pattern. Ideally, one would like to developa TNF mutant that has retained its cytotoxic action on tumourcells without inducing the deleterious systemic toxteity. Suchan optimized TNF molecule could become a potent anticancer agent 相似文献
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Nucleation kinetics during the growth of InxGa1−xN on a GaN substrate have been studied. The behavior of nonequilibrium between the InxGa1−xN and the GaN substrate has been analyzed, and hence, the expression derived for the stress-induced supercooling/superheating
has been numerically evaluated. The maximum amount of stress-induced supercooling is found to be 1.017 K at x=0.12. These
values are incorporated in the classical heterogeneous nucleation theory. Using the regular solution model, the interfacial
tension between the nucleus and substrate and, hence, the interfacial tension between nucleus and mother phase and thermodynamical
potential of the compounds have been calculated. The amount of driving force available for the nucleation has been determined
for different compositions and degrees of supercooling. It has been shown that the value of the interaction parameter of InN-GaN
plays a dominant role in nucleation and growth kinetics of InxGa1−xN on a GaN substrate. These values have been used to evaluate the nucleation parameters. It is shown that the nucleation barrier
for the formation of a InxGa1−xN nucleus on a GaN substrate is minimum in the range of x=0.12 to x=0.17, and it has been qualitatively proved that good quality
InxGa1−xN on GaN can be grown only in the range 0<x≤0.2. 相似文献
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讨论了多重帐户问题在计算机网络管理中诸多弊端。提出以目录服务(Novell NDS)为基础,实现跨平台(NetWare、WindowsNT和Solaris)的帐刻统一管理的方案及详细实施实例。 相似文献