电痛阈测定法对光敏剂亚甲兰镇痛效果的评定

目的:利用电痛阈测定法精确评定光敏剂亚甲兰的镇痛效应.方法:50只SD大鼠随机分为5组:生理盐水组、0.25%亚甲兰组、0.5%亚甲兰组、0.75%亚甲兰组、1%亚甲兰组.将清醒大鼠的右下肢给予刺激,左肢引导,给予以0.28mA为起始强度、0.02mA为阶梯值的5个串长的连续递增的电刺激,观察给予一定的刺激强度后经过一定的潜伏期后出现第一个复合波形后的相对应的电流值,作为动物给药前之基础痛阈值.选择靠近刺激电极中枢段的右侧坐骨神经为阻断点,神经刺激器定位,注射药物,同样的方法观察记录给药后的1h、2h、3h、4h、6h、8h、12h、24h的痛阈的变化,来确定约物的镇痛效果及药物的起效时间和作用高峰时间.结果:0.25%组亚甲兰无效应,0.5%组在4小时起效,与对照组比较有显著差异,但是很快又恢复至对照水平.0.75%组滓射后3d小时起效果,与对照组比较有显著差异,且这种效果可以持续12小时:1%组注射后2小时起效果,与对照组比较有显著差异,且这种效果可以持续24小时之久.结论:亚甲兰可以提高大鼠的痛阈值,且有浓度递增效应.0.75%组和1%组阻滞效果显著,2小时至3小时起效,4小时达高峰.     

Phenothiazinium photosensitisers IX. Tetra- and pentacyclic derivatives as photoantimicrobial agents

Methylene blue derivatives, synthesised as novel photosensitising agents are usually simple auxochromic variations on the lead compound. The current paper represents the initial report on the synthesis and biological testing of a new class of phenothiazinium derivatives, having either one or two tetrahydropyridine rings fused to the phenothiazinium chromophore. The derivatives exhibited extended absorption wavelengths, increased amphiphilic character and much greater photoantimicrobial efficacies compared to methylene blue, some examples being more effective even than dimethyl methylene blue. The high activities of this class of photosensitiser recommend its use in infection control, both locally and in blood product decontamination.     

运行中的GIS不同部位盘式绝缘子超宽频带局部放电特性试验研究

采用超宽频带局部放电测试系统,研究了玉泉变运行中的110kV电压等级GIS各关键部位盘式绝缘子的超宽频带局部放电信号。试验结果发现,运行中的GIS不同部位的盘式绝缘子具有各不相同的局部放电特征,且放电频率主要集中在300MHz频率段以下,为今后GIS在线监测提供了数值依据。     

牵引式火炮行军安全保护系统研究

根据炮兵部队和军事院校机动训练的需要，针对拉练过程中经常出现的因火炮机械原因产生的故障，为及时有效地排除火炮行军过程中存在的隐患，设计“牵引式火炮行军安全保护系统”，结合火炮的机械特点，设计环形垫片式测力传感器，采用曲线拟合的方法对任意路面进行测量。     

Advanced photospacers with elastic recovery

A new series of photospacers has been prepared with different types of crosslinkers to improve elastic recovery. Afunctional crosslinker with six reactive groups demonstrates the best elastic recovery. As the quantity of crosslinker is increased, the elastic recovery also increases, probably due to an increase in the crosslinking density. The use of ADMS EPS® results in high resolution, good uniformity, and high production yield in the liquid‐crystal‐display (LCD) process. Especially, EPS® improves and solves problems such as viewing angle, crosstalk, and dark spots.     

Sorption Behavior and Mechanism of Indium（ Ⅲ ） onto Amino Methylene Phosphonic Acid Resin

The sorption behavior of amino methylene phosphonic acid resin (APAR) for In(III) was investigated. Experimental results show that In(III) adsorbed on APAR can be eluted with 2mol·L⁻¹ HCl. The apparent rate constant is k₂₉₈=1.50×10⁻⁵s⁻¹. The sorption behavior of APAR for In(III) obeys the Freundlich isotherm. The thermodynamic parameters of sorption, enthalpy change ΔH, free energy change ΔG and entropy change ΔS of sorption (APAR) for In(III) are 24.1kJ·mol⁻¹, −35.1kJ·mol⁻¹ and 200J·mol⁻¹·K⁻¹, respectively. The coordination molar ratio of the functional group of APAR to In(III) is 2∶1. The sorption mechanism of APAR for In(III) was examined by IR spectrometry. XIONG Chun-hua: Born in 1959 0 This project was supported by Foundation of Zhejiang Provincial Education Bureau(No.20010677) and Lishui Science and Technology Bureau(No.2001012).     

Extensive chromosome translocation in a clinical isolate showing the distinctive carbohydrate assimilation profile from a candidiasis patient

Variation of the electrophoretic karyotype is common among clinical strains of Candida albicans and chromosome translocation is considered one of the causes of karyotypic variation. Such chromosome translocations may be a mechanism to confer phenotypic diversity on the imperfect fungus C. albicans. A clinical strain, TCH23, from a vaginal candidiasis patient shows distinct carbohydrate assimilation profile, serotype B, no chlamydospore formation and an atypical karyotype (Asakura et al., 1991). To examine the taxonomic relationship among C. albicans, Candida dubliniensis and this strain, we sequenced the internal transcribed spacer 1 (ITS1) of nuclear ribosomal DNA. The ITS1 sequence of TCH23 was identical with that of C. albicans but not of C. dubliniensis. Thus, strain TCH23 was classified as a variant of C. albicans with an atypical phenotype. The chromosomal DNAs of this strain were resolved into 13 bands on pulse-field gel electrophoresis (PFGE). Using DNA probes located at or near both ends of each chromosome of C. albicans, we investigated the chromosome organization of this strain. Referring to the SfiI map of C. albicans 1006 (Chu et al., 1993), we found that seven chromosomal DNA bands in strain TCH23 were reciprocal chromosome translocations. One homologue from chromosomes 1, 2 and 6 and both homologues from chromosomes 4 and 7 participated in these events. One translocation product was composed of three SfiI fragments, one each from chromosomes 2, 4 and 7. We deduced the breakpoints of chromosome translocation from the physical map of this strain; between 1J and 1J1, between 2A and 2U, both ends of 4F2, between 6C and 6O and both ends of 7F.     

纳米硫化镉的制备、表征及其光催化性能研究

以CdCl2和Na2S为主要原料，制备了纳米CdS颗粒，通过X射线衍射（XRD）和扫描电镜（SEM）分析其晶型和粒径，通过紫外-可见漫反射的表征，计算其带隙能，并用BET法测定其比表面积．通过对CdS固体的红外光谱的分析，研究颗粒的表面状况。将制备的纳米CdS颗粒用于亚甲基蓝的光催化降解反应，通过空白实验和暗反应实验的对比证明，自制的纳米CdS颗粒具有良好的光催化性能．最后还通过多次实验证明了自制Cds具有持久的光催化寿命．     

氧化铁/绢云母复合光催化剂降解次甲基蓝

采用水热合成法，在绢云母表面沉淀一层氧化铁薄膜，制备成氧化铁/绢云母复合光催化剂。并以次甲基蓝为降解物，重点探讨了催化剂后处理方式、体系H2O2浓度和催化剂添加量对光催化效率的影响。结果证明，复合光催化剂煅烧前比煅烧后降解效果更好；体系H2O2浓度为0.5%、光催化剂用量为5 g/L时，降解效果最佳。     

玉米多孔淀粉吸附性能研究

研究玉米多孔淀粉对次甲基蓝的吸附特性,借助于全自动气体吸附仪和分光光度计等仪器研究多孔淀粉的孔结构参数和对次甲基蓝色素的的吸附动力学特征,并建立多孔淀粉的等温吸附方程及其吸附速率方程.在柱吸附过程中,多孔淀粉吸附次甲基蓝的最佳吸附浓度为6×10-5mol/L,多孔淀粉对次甲基蓝的饱和吸附量为1.41 mg/g,且270 min达到饱和吸附量.结果表明,与原淀粉相比,多孔淀粉的比表面积、比孔容、孔径大小均增大,这说明多孔淀粉是良好的吸附载体,能够吸附更多功能性目的物质.