高效液相色谱法测定盐酸度洛西汀中1-萘酚的含量

建立一种适用于测定盐酸度洛西汀中1-萘酚的测定方法。色谱柱为AgilentC18柱(5μm,4.6mm×250mm);磷酸盐缓冲溶液(pH=5.8)-乙腈(63∶37)为流动相;检测波长为230nm;柱温为30℃;流速1.0mL/min;进样体积为10μL。样品中盐酸度洛西汀和1-萘酚分离度良好,1-萘酚的最低检测限为0.132ng。所建立的方法简便、快速,可准确地分离盐酸度洛西汀中的1-萘酚,并能有效监控产品中的主要有关物质。     

One-step purification of ethylene from acetylene and carbon dioxide by ultramicroporous carbons

The one-step adsorptive separation of high-purity ethylene (C₂H₄) from a ternary gas mixture (C₂H₂/C₂H₄/CO₂) is challenging and has not been reported on porous carbons. Herein, we report camphor seeds husk-derived ultramicroporous carbons (CSHs) show high affinities toward acetylene (C₂H₂) and carbon dioxide (CO₂) over C₂H₄. The optimized CSH-2-700 with high heteroatom contents and centered pore size distributions shows high C₂H₂ adsorption capacity (2.24 mmol g⁻¹) and record ideal adsorbed solution theory (IAST) C₂H₂/C₂H₄ selectivity (10.2) among one-step C₂H₄ purification adsorbents. Meanwhile, CSH carbons are the only carbon adsorbents that preferentially adsorb CO₂ over C₂H₄, with a CO₂/C₂H₄ selectivity of 1.9 under ambient conditions. Furthermore, dynamic breakthrough experiments verified its feasibility for one-step C₂H₄ purification from a three-component C₂H₂/C₂H₄/CO₂ gas-mixture.     

Adsorption behaviors and mechanisms of porous hypercrosslinked polymers with adjustable functional groups toward doxycycline hydrochloride from water

Imino hypercrosslinked polymers (NH-HCPs), amino hypercrosslinked polymers (NH₂-HCPs), and carboxyl hypercrosslinked polymers (COOH-HCPs) were synthesized through cross-linking and Friedel-Crafts reactions to serve as highly efficient adsorbents for doxycycline hydrochloride (DOX) in water. These polymers, NH-HCPs, NH₂-HCPs, and COOH-HCPs, exhibited specific surface areas measuring 450, 267.576, and 94.39 m²/g, respectively. The adsorption kinetics of DOX onto these polymers were consistent with the pseudo-second-order model, while the adsorption isotherms followed the Langmuir model (NH-HCPs) and Freundlich model (NH₂-HCPs and COOH-HCPs), respectively. The maximum DOX adsorption capacities for NH-HCPs, NH₂-HCPs, and COOH-HCPs were 166.82, 132.43, and 72.07 mg/g, respectively. Simulation results indicated that COOH-HCPs exhibited the strongest adsorption capability due to a substantial presence of oxygen and nitrogen groups on its surface, enabling the formation of hydrogen bonds with DOX. However, its actual adsorption capacity was the lowest among the polymers, indicating that structural adjustments played a more significant role in improving adsorption performance compared to functional adjustments. Adsorption experiments conducted with NH-HCPs and NH₂-HCPs further supported this hypothesis. The primary DOX adsorption mechanism of NH-HCPs, NH₂-HCPs, and COOH-HCPs involved the H-bonding of oxygen and nitrogen functional groups, along with other mechanisms such as π-π conjugated effects, pore-filling effects, electrostatic interactions, and acid–base interactions. Overall, this study demonstrates the effectiveness of NH-HCPs, NH₂-HCPs, and COOH-HCPs in DOX removal from water, highlighting the significant influence of structural adjustments on adsorption performance.     

L-半胱氨酸盐酸盐对曲奇中4种有害醛类形成的抑制作用及其品质的改善效果

该研究将L-半胱氨酸盐酸盐添加到面团中制作曲奇,研究了不同添加量（0.3、0.6、1.0、1.5 g/kg）L-半胱氨酸盐酸盐对4种有害醛类含量、曲奇外观和挥发性物质的影响。结果表明：添加后,曲奇的接受度高于未添加对照组,且4种有害醛类的含量显著降低。当L-半胱氨酸盐酸盐添加量为1.5 g/kg时,曲奇中5-羟甲基糠醛、3-脱氧葡萄糖醛酮、乙二醛和丙酮醛含量分别降低28.75%、62.73%、46.27%、36.59%。微固相萃取-气质联用结果显示：添加后,曲奇的挥发性醛、醇和吡嗪类物质含量增加,大部分酮类物质含量减少。细胞毒性实验结果显示：添加L-半胱氨酸盐酸盐的曲奇水提取物添加对人胃粘膜上皮细胞活力有促进作用。结合实验分析,曲奇最适L-半胱氨酸盐酸盐添加量为1.0 g/kg。     

Skin permeation of buflomedil form adhesive matrix patches

The main objective of this research work was to fabricate and evaluate adhesive matrix-type transdermal patches of buflomedil hydrochloride, employing different ratios of pressure sensitive adhesives (PSAs) by solvent casting technique. The adhesive matrix-type transdermal patches were evaluated by their in vitro physicochemical properties such as thickness, moisture content, weight variation, drug content uniformity, etc. The effects of PSAs ratio, drug loading, and concentration of permeation enhancer were evaluated thoroughly. Ex vivo skin permeation studies with kinetic modeling of adhesive matrix patches were systematically evaluated. Based on the above observations, the best optimized buflomedil hydrochloride-loaded adhesive matrix-type transdermal patch was further characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction study, and differential scanning calorimetry analyses. Drug containing adhesive matrix patches showed sustained release property without showing any incompatibility in adhesive matrix system. Hence, adhesive matrix-type transdermal patches of buflomedil hydrochloride can be used as a potential carrier for sustained transdermal delivery of hydrophilic drugs like buflomedil hydrochloride.     

盐酸克伦特罗完全抗原的合成及其偶联工艺的优化

为获取用于快速免疫分析的免疫抗原和包被抗原,本实验采用重氰化反应制备盐酸克伦特罗(Clenbuterolhydrochloride,CL)完全抗原,在强酸条件下CL先经重氮化,再与鸡卵清白蛋白(OVA)发生共价取代制备了盐酸克伦特罗包被抗原(OVA-CL),并以正交实验确定了共价取代反应的关键影响因素,进一步采用单因素实验确定了反应所需的最佳条件,并通过紫外扫描对制得的包被抗原进行了鉴定.结果表明,投料比例是盐酸克伦特罗完全抗原合成的关键因素,搅拌转速和反应时间也起着至关重要的作用.而且偶联反应在l h内基本完成,延长反应时间对提高产物偶联比影响不大.当投料比例为30:1,pH值约为8,低速搅拌状况下,包被抗原和免疫抗原的偶联比分别高达29:1和48:l,盐酸克伦特罗完全抗原合成条件的优化筛选取得了预期的效果.     

Taste response to mixtures: Analytic processing of quality.

The tastes of 100 mM sodium chloride (NaCl), 100 mM sucrose, and 1 mM quinine hydrochloride in mixtures were investigated in golden hamsters (Mesocricetus auratus) with a conditioned taste aversion (CTA) paradigm. CTAs, established in golden hamsters by injection of lithium chloride, were quantified as percent suppression of control 1-hr stimulus intake. CTAs for 10 of 15 stimulus pairs with common components symmetrically cross-generalized, suggesting that component qualities were recognized in binary and ternary mixtures. However, CTAs to quinine were hardly learned and were weakly expressed when quinine was mixed with NaCl, and generalizations from multiple to single stimuli were stronger than vice versa (i.e., asymmetric). The behaviors reflect peripheral inhibition and/or central mixture suppression. Nonetheless, components retain their distinct qualities in mixtures, suggesting that taste processing is analytic. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

1,3-二溴丙酮和1,3-二氨基丙酮盐酸盐的合成

丙酮与溴素(mol比为1:2.03)在冰醋酸存在下发生取代反应,分离提纯后得三种产物。经过IR和NMR分析,可确定主要产物为1,3-二溴丙酮。1,3-二溴丙酮为淡黄色液体(25℃),折光率n_D~(20)为1.553 2。1.3-二溴丙酮与六次甲基四胺成盐物分别在盐酸、乙醇中水解得淡黄色粉状固体。经过IR分析,证明生成物为1,3-二氨基丙酮盐酸盐。     

硫杆菌的化学诱变及对低品位黄铜矿的浸出

用盐酸羟胺将氧化铁硫杆菌优势菌(T、f菌)化学诱变后对低品位黄铜矿进行细菌浸出，结果表明，盐酸羟胺化学诱变能够使T．f菌产生较明显的变异，能较好地提高菌种的活性和对低品位黄铜矿的牛物浸出性能。经盐酸羟胺化学诱变，T．f诱变菌的活性比原始T．f菌提高了57．4％，对黄铜矿的浸出率提高了11．5％，达到浸出终点的时间比原始T．f菌减少了5～10d。     

环（D-天冬氨-D-脯）二肽的合成

以D-天冬氨酸和D-脯氨酸为原料,先合成N-叔丁氧羰基-D-天冬氨酸-β-苄酯和D-脯氨酸甲酯盐酸盐,然后经DCC缩合得直链二肽,再经Pd/C催化氢解,HCl/Et2O脱Boc保护,最后弱碱性条件下成环得环（D-天冬氨-D-脯）二肽,结构经ESI-MS、IR、^1HNMR、^13CNMR等表征。