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101.
102.
Kristin R. Gleitsman Henry A. Lester Dr. Dennis A. Dougherty Dr. 《Chembiochem : a European journal of chemical biology》2009,10(8):1385-1391
Probing the sheet : The network of hydrogen bonds formed in the outer β sheet of the nicotinic acetylcholine receptor (nAChR; see figure) is fairly robust and tolerates single amide‐to‐ester mutations throughout. However, eliminating two proximal hydrogen bonds completely destroys receptor function; this adds further support to gating models that ascribe important roles to these β strands of the nAChR extracellular domain.
103.
104.
Madalena C. Pinto Margarida C. Quaresma Iris A. L. Silva Violeta Railean Sofia S. Ramalho Margarida D. Amaral 《International journal of molecular sciences》2021,22(23)
SLC26A9, a constitutively active Cl− transporter, has gained interest over the past years as a relevant disease modifier in several respiratory disorders including Cystic Fibrosis (CF), asthma, and non-CF bronchiectasis. SLC26A9 contributes to epithelial Cl− secretion, thus preventing mucus obstruction under inflammatory conditions. Additionally, SLC26A9 was identified as a CF gene modifier, and its polymorphisms were shown to correlate with the response to drugs modulating CFTR, the defective protein in CF. Here, we aimed to investigate the relationship between SLC26A9 and CFTR, and its role in CF pathogenesis. Our data show that SLC26A9 expression contributes to enhanced CFTR expression and function. While knocking-down SLC26A9 in human bronchial cells leads to lower wt- and F508del-CFTR expression, function, and response to CFTR correctors, the opposite occurs upon its overexpression, highlighting SLC26A9 relevance for CF. Accordingly, F508del-CFTR rescue by the most efficient correctors available is further enhanced by increasing SLC26A9 expression. Interestingly, SLC26A9 overexpression does not increase the PM expression of non-F508del CFTR traffic mutants, namely those unresponsive to corrector drugs. Altogether, our data indicate that SLC26A9 stabilizes CFTR at the ER level and that the efficacy of CFTR modulator drugs may be further enhanced by increasing its expression. 相似文献
105.
Jinfeng Zeng Zhiting Liu Hanbo Zou Wei Yang Haosen Fan Haijun Yu Shengzhou Chen 《金属学报(英文版)》2021,34(8):1153-1162
A appropriate size with three-dimension(3 D) channels for lithium diffusion plays an important role in constructing highperforming LiNi_(0.5)Mn_(1.5)O_4(LNMO) cathode materials, as it can not only reduce the transport path of lithium ions and electrons, but also reduce the side effects and withstand the structural strain in the process of repetitive Li~+ intercalation/deintercalation. In this work, an e fficient method for designing the hollow LNMO microsphere with 3 D channels structure by using polyethylene oxide(PEO) as soft template agent assisted solvothermal method is proposed. Experimental results indicate that PEO can make the reagents mingle evenly and nucleate slowly in the solvothermal process, thus obtaining a homogeneous distribution of carbonate precursors. In the final LNMO products, the hollow 3 D channels structure obtained by the decomposition of PEO and carbonate precursor in the calcination can provide abundant electroactive zones and electron/ion transport paths during the charge/discharge process, which benefits to improve the cycling performance and rate capability. The LNMO prepared by adding 1 g PEO possesses the most outstanding electrochemical performance, which presented an excellent discharge capacity of 143.1 mAh g~(-1) at 0.1 C and with a capacity retention of 92.2% after 100 cycles at 1 C. The superior performance attributed to the 3 D channels structure of hollow microspheres, which provide uninterrupted conductive systems and therefore achieve the stable transfer for electron/ion. 相似文献
106.
107.
The magnetism of pentlandite surface was enhanced through the selective precipitation of micro-fine magnetite fractions on pentlandite surfaces. This was achieved through adjustment of slurry pH and addition of surfactants. The results showed that at pH 8.8 with the addition of 100 g/t sodium hexametaphosphate, 4.5 L/t oleic acid, and 4.5 L/t kerosene, significant amount of fine magnetite particles adhered to the pentlandite surface, while trace amount of coating was found on serpentine surfaces. Thus, the magnetism of pentlandite was enhanced and pentlandite was well separated from serpentine by magnetic separation under the magnetic field intensity of 200 kA/m. Scanning electron microscopy (SEM) and zeta potential measurement were performed to characterize changes of mineral surface properties. Calculations of the extended Derjaguin–Landau–Verwey–Ocerbeek (EDLVO) theory indicated that, in the presence of surfactants the total interaction energy between magnetite and pentlandite became stronger than that between magnetite and serpentine. This enabled the selective adhesion of magnetite particles to pentlandite surfaces, thereby enhancing its magnetism. 相似文献
108.
The effects of pouring temperature, vibration frequency, and the number of curves in a serpentine channel, on the microstructure and mechanical properties of Al–30%Si alloy processed by rheo-diecasting (RDC) were investigated. The semisolid Al–30%Si alloy slurry was prepared by vibration serpentine channel pouring (VSCP) process in the RDC process. The results show that the pouring temperature, the vibration frequency, and the number of the curves strongly affect the microstructure and mechanical properties of Al–30%Si alloy. Under experimental conditions of a pouring temperature of 850 °C, a twelve-curve copper channel and a vibration frequency of 80 Hz, the primary Si grains are refined into fine compact grains with average grain size of about 24.6 μm in the RDC samples assisted with VSCP. Moreover, the ultimate tensile strength (UTS), elongation and hardness of the RDC sample are 296 MPa, 0.87% and HB 155, respectively. It is concluded that the VSCP process can effectively refine the primary Si grains. The refinement of primary Si grains is the major cause for the improvement of the mechanical properties of the RDC sample. 相似文献
109.
以金属钛和钨为过渡层,采用PE-HFCVD法在硅基上制备金刚石薄膜,并对薄膜的场发射特性分析研究。结果表明,金属过渡层对金刚石薄膜场发射性能有显著的增强作用。以金属钨为过渡层时,金刚石薄膜的场发射开启场强为5.4 V/μm,比无过渡层降低了44%;场发射电流密度在电场强度为8.9 V/μm时达到1.48 mA/cm2。通过对薄膜的结构表征知,场发射性能的增强主要与界面处电子运输势垒的降低及薄膜中sp2 C含量的增加有关,在界面处及金刚石膜内形成良好的导电通道,使电子更容易运输至薄膜表面,从而表现出优异的场发射性能。 相似文献
110.
蛇纹石尾矿是蛇纹石开采、利用过程中产生的固体废弃物,是我国排放量较大的矿业固体废弃物之一,也是可回收利用的二次资源。本文介绍了蛇纹石尾矿对环境的危害,分析了蛇纹石尾矿的物理化学性质,总结出资源化利用的途径。 相似文献