哌嗪基[口恶]唑烷酮类衍生物的合成及其体外抗菌活性研究

以S-环氧氯丙烷和3,4-二氟硝基苯为原料,设计并合成了12个哌嗪取代[口恶]唑烷酮类化合物,其结构均经高分辨1HNMR和MS确认。以利奈唑胺为参照物,对合成的化合物进行了金黄色葡萄球菌、链球菌和大肠杆菌的体外抗菌实验,结果表明,合成的化合物有一定抗菌活性,但活性均明显低于利奈唑胺。     

一维NiFe1.98RE0.02O4(RE=Pr, Nd, Sm)纳米丝的结构和磁性能

采用溶胶-凝胶法、静电纺丝技术和热处理技术相结合制备了一维NiFe_(1.98)RE_(0.02)O_4 (RE=Pr,Nd,Sm)纳米丝。利用X射线衍射仪(XRD)、傅里叶变换红外光谱仪(FT-IR)、扫描电子显微镜(SEM)和振动样品磁强计(VSM)对NiFe_(1.98)RE_(0.02)O_4 (RE=Pr,Nd,Sm)纳米丝的结构、形貌和磁性能进行表征。结果表明,NiFe_(1.98)RE_(0.02)O_4(RE=Pr,Nd,Sm)纳米丝表面光滑、直径均匀、连续,直径约60nm。掺杂Pr~(3+),Nd~(3+),Sm~(3+)均没有改变NiFe204的尖晶石结构,掺杂均降低了NiFe_2O_4的结晶度,晶粒尺寸D从44.8nm减小到33.8nm。NiFe_(1.98)RE~(0.02)O_4 (RE=Pr,Nd,Sm)纳米丝都表现出软磁特性。NiFe_(1.98)RE_(0.02)O_4 (RE=Pr,Nd,Sm)纳米丝的饱和磁化强度(Ms)分别为39.58,41.10,34.23 A·m~2/kg;矫顽力(H_c)分别为14119.2, 13678.4,15937.6 A/m;其中NiFe_(1.98)Nd_(0.02)O_4纳米丝的M_s (41.10 A·m~2/kg)最大,矫顽力H_c(13678.4A/m)最小,软磁性能最好。     

A duplex coating composed of electrophoretic deposited graphene oxide inner-layer and electrodeposited graphene oxide/Mg substituted hydroxyapatite outer-layer on carbon/carbon composites for biomedical application

A duplex coating composed of electrophoretic deposited graphene oxide (GO) inner-layer and electrodeposited GO/Mg substituted hydroxyapatite (MH) outer-layer was prepared on carbon/carbon composites (CC). The morphology and microstructure of GO-GO/MH coating were researched by Scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray diffraction, Raman spectroscopy and X-ray photoelectron spectroscopy. The bonding strength between GO-GO/MH coating and CC substrate was investigated by shear test. The in-vitro bioactivity of GO-GO/MH coating was analyzed by simulated body fluid (SBF) immersion test. The results demonstrated that electrophoretic deposited GO inner-layer was successfully introduced on CC and could serve as an interlayer between CC and following electrodeposited GO/MH outer-layer. GO/MH outer-layer presented a flake morphology with 150–250?nm in thickness and 1.5–2.5?µm in width, exhibiting porous three-dimensional networks structure uniformly. The shear test showed that the bonding strength between the duplex coating and CC reached 7.4?MPa, which was 80.49% higher than that of single-layered MH coating without GO. The duplex coating could induce the formation of flocculent and chapped apatite after SBF immersion, which demonstrated the in-vitro bioactivity of the duplex coating. These results suggested that GO-GO/MH coating might be a promising candidate in the field of biomaterials, especially for implant coatings.     

Highly soluble perylene dyes: Synthesis, photophysical and electrochemical characterizations

Highly soluble perylene diimide derivatives with symmetrical and unsymmetrical secondary, tertiary alkyl side chains were synthesized and their photophysical properties, redox potentials and thermal stabilities were measured and compared with previously reported 1-pentylhexyl substituted swallow-tailed perylene diimide. Diasteroisomers of the novel, unsymmetrical swallow-tailed substituted perylene diimide compound could not be detected using low temperature NMR spectroscopy. The novel dyes were soluble in a range of organic solvents indicating potential for photo-electronic applications and photocatalytic reactions. Two dyes were not only soluble in organic solvents but also showed solubility in aqueous media as the hydrochloride salt, thus offering potential use in biological applications.     

取代苯甲酸葡萄糖酯的合成及生物活性

以两种方法合成了10个取代苯甲酸葡萄糖酯类化合物，一是相转移催化法，二是在三忆胺的存在下，取代苯甲酸与溴代葡萄糖反应，该种合成糖酯的方法未见文献报道，取代苯甲酸葡萄糖酯的结构由IR、MS、^1H NMR和元素分析确认。对化合物的抗病毒活性测试结果发现，其中有两个化合物具有一定的抑制TMV的活性。     

新的价连接性指数~mX用于有机化合物的QSAR

定义新的价连接性指数 m X、m X′,并用于有机化合物的定量结构 -活性相关性研究中 ,发现 m X、m X′与有机物的毒性具有良好的线性关系 ,相关系数均在 0 .92以上 ,优于文献方法。该法具有计算简单 ,物理意义明确等优点。     

氮四取代苯二胺新型除氧剂的研究

介绍了氮四取代苯二胺类新型除氧剂的除氧性能，选取其中的N，N，N'，N'－四甲基对苯二胺为主要研究对象，与N2H4和丙酮肟的除氧性能进行了对比，研究了其缓蚀性能。试验结果表明，氮四取代苯二胺是一种性能优良的新型除氧剂。     

生物电子等排及其在新农药创制中的应用

本文简要叙述了生物等排的概念，发展史及其作为有效方法之一在新农药创制中的应用。文中给出许多运用生物电子等排成功开发的新农药实例。     

Catalytic behavior of vanadium substituted mesoporous molecular sieves

A series of V-MCM-41 samples with different pore sizes has been systematically investigated with both gas and liquid phase reactions. Methanol oxidation has been performed in the gas phase on these catalysts. Turnover frequencies are normalized by oxygen uptake measured under reaction conditions. A strong effect of pore size on the catalytic activity was observed in the form of a “volcano curve” and may be correlated with a variation in the local bond angle of Si–O–V. Considering this effect, the catalytic activity may be ‘tuned' to maximum by varying the pore size. As expected, the same effect was observed in the liquid phase oxidation of cyclohexene. In order to interpret the pore size effect, the reaction rates of both the gas phase and liquid phase oxidation were then correlated with the variation of edge energies of V K-edge XANES on these MCM-41 catalysts. Additional reactions were performed in the liquid phase to compare the activity of V-MCM-41 with that of crystalline vanadium and titanium silicalite zeolites. The possible causes of the difference in the catalytic behaviors of these materials is also discussed.     

Highly Diastereoselective Indium‐Mediated Allenylation of N‐tert‐Butanesulfinyl Imino Ester: Efficient Synthesis of Optically Active α‐Allenylglycines

An efficient and practical asymmetric synthesis of highly enantiomerically enriched α‐allenylglycines by room temperature indium‐mediated allenylation of chiral N‐tert‐butanesulfinyl imino esters with propargylic halides is described. The synthetic utilities of the approach were demonstrated by the rapid and convenient preparation of challenging cis‐substituted proline derivatives.