Fingerprinting G-protein-coupled receptors

Recently we reported the design of a discriminating fingerprintfor rhodopsin-like G-protein-coupled receptors (GPCRs). Thefingerprint encodes the seven putative membrane-spanning motifsand was potently diagnostic of all GPCRs (52 in all) in version8.1 of the OWL composite sequence database, readily distinguishingthem from all other integral membrane proteins. With a 3-foldincrease in the size of OWL, the fingerprint has been updatedand now finds 332 receptors that match all the motifs. The situation,however, has grown in complexity: 61 sequences make imperfectmatches with the fingerprint, yielding a total of 393 ‘hits’.The bulk of the partial hits are olfactory receptors: theseappear to fall into discrete subfamilies in which one or moreof the transmembrane motifs are either poorly matched or arenot matched at all. These results are supported by preliminaryphylogenetic analyses, which show the olfactory and variousother partial matches clustering away from the main body oftrue hits. The approach has provided a powerful diagnostic toolfor identifying GPCRs, and results are consistent with previousobservations that the pheromone, cAMP and secretin-like receptorsbelong to separate families-these bear their own unique sequencefingerprints by which they may be distinguished from the rhodopsin-likesuperfamily     

PARTICLE FLOW PATTERNS IN THE RISER AND DOWNER OF CIRCULATING FLUIDIZED BED

This paper presents an experimental study on the flow patterns of FCC particles in a 140 mm ID Circulating Fluidized Bed with concurrent upflow and downflow gas-solid suspension. Based on the distribution of local particle velocity and particle concentration measured by a Fiber-Optical Probe Laser Doppler Velocimeter and a Fiber Optical Probe System respectively, the different flow patterns of local particls concentration, local particle velocity, local particle fluctuating velocity and sectionally average particle velocity in concurrent upflow and downflow gas-solid system have been investigated. It is found that the particle flow in the concurrent downflow is much more uniform radially than that in the concurrent upflow riser. The investigation of flow patterns in different flow systems is of significance to the development of a new gas-solid reactor.     

CCFW的一种新型张力控制方法研究

通过一个实例介绍了计算机控制缠绕机（CCFW）的一种缠绕纤维的张力控制方法，着重分析了其技术要求与难点，并给出了最终的实现方法。这种方法对于造纸，纺织工业设备及其他缠绕设备的张力控制都极具参考价值。     

基于Bayes特征判别的选煤建模与识别

研究了煤块的Harr小波变换和幅度投影分析,在对原始图像进行特征判别分析的基础上,建立了煤块和煤矸石的统计模型,提出了用Bayes判别函数分选煤块和煤矸石的算法,实现了用计算机视觉系统对样本进行了识别检验.并运用神经网络BP算法进行训练识别,检验其正确性,最后通过实验验证了算法有效性.     

复合材料纤维缠绕成型CAD/CAM相关技术研究

纤维缠绕成型是制造高强度复合材料制品的一种重要的工艺方法，将CAD／CAM方法应用其中可以大大提高生产效率，降低设计成本。本文提出了纤维缠绕CAD／CAM系统的总体方案，并对其中缠绕数学模型、线型优化、丝嘴轨迹生成等量要组成部分进行了分析与研究，为CAD／CAM系统的开发奠定了理论基础。     

硼在玉米中的分布特征及化学形态的研究

对施硼肥和不施硼肥的土壤上种植的玉米中硼的分布及化学形态进行了研究 ,结果表明 ,靠近根部的玉米叶子中含硼最多 ,中部和上部叶子中含硼量依次递减 ,玉米种子中的含硼量低于叶子中的含硼量。通过研究不同溶剂对玉米叶子和种子中硼的浸提能力 ,探明了以 10 %醋酸浸提下来的硼最多 ,其次是用 0 .0 1mol/LEDTA浸提下来的硼 ,用水浸提下来的硼的含量最少。     

一种混合的离散细菌菌落优化算法

为了利用细菌算法解决组合优化问题, 提出了一种混合的离散细菌菌落优化算法。根据现有细菌优化算法, 设计一种新的个体编码方式及进化模式, 通过设计种群的自适应调整因子增强个体活力, 并融合禁忌搜索算法, 克服算法易于陷入过早收敛的不足, 并与其他算法在Taillard标准调度测试问题集上比较实验, 验证了算法的有效性。仿真结果表明, 该算法可以搜索到问题的最优组合, 能够有效避免算法陷入局部最优, 取得了满意的结果。     

基于αβ运算的多层联想记忆模型的研究

介绍了αβ运算符的定义和αβ联想记忆矩阵的四种操作。通过四种矩阵操作来实现模式对的培训和回忆。αβ多层联想记忆模型相比形态学联想记忆模型数值计算相对容易。最后,通过αβ多层联想记忆的数字模拟实例验证了αβ多层联想记忆具有良好的回忆性能。     

基于模拟分析技术和随机搜索算法的化工过程能量集成方法研究

夹点和模拟分析技术已在化工能量集成中广泛应用.今以夹点技术为基础,对化工过程系统用能进行诊断,根据"过程用能一致性"原则提出能量集成改造方案,通过改变塔压实现塔顶冷凝器与塔底再沸器的热集成多效蒸馏.夹点技术实现的优化目标仅是热回收最大或公用工程能耗最小,不能实现包括设备整体费用最小的过程全局最优化.研究基于模拟技术,通过灵敏度分析,得到精馏塔各操作参数的样本映射数据,通过多项式拟合得到参数关联方程,并在遗传算法及模式搜索中设计过程费用函数,提出了将模拟分析技术与随机搜索算法相结合的,以过程费用函数最小化为优化目标的能量集成方法.工业实例的成功设计应用证明了其有效性和可行性.