全层片状TiAl基合金断裂过程的原位观察

利用ＳＥＭ拉伸台，研究了Ｔｉ－３３Ａｌ－３Ｃｒ－０．５Ｍｏ合金的室温拉伸断裂动态过程。试验结果表明，具有全层片状显微组织的ＴｉＡｌ合金室温断裂韧性较高，归因于合金拉伸过程中裂纹尖端发生分叉致使应力松弛而使裂纹钝化；在变形过程中，主裂纹尖端附近的微裂纹之间形成剪切韧带，剪切韧带韧化是ＴｉＡｌ合金的一种韧化机理。     

Genomic and Immunological Characterization of Hypermucoviscous Carbapenem-Resistant Klebsiella pneumoniae ST25 Isolates from Northwest Argentina

In recent years, an increase in the prevalence hypermucoviscous carbapenem-resistant Klebsiella pneumoniae with sequence type 25 (ST25) was detected in hospitals of Tucuman (Northwest Argentina). In this work, the virulence and the innate immune response to two K. pneumoniae ST25 strains (LABACER 01 and LABACER 27) were evaluated in a murine model after a respiratory challenge. In addition, comparative genomics was performed with K. pneumoniae LABACER01 and LABACER27 to analyze genes associated with virulence. Both LABACER01 and LABACER27 were detected in the lungs of infected mice two days after the nasal challenge, with LABACER01 counts significantly higher than those of LABACER27. Only LABACER01 was detected in hemocultures. Lactate dehydrogenase (LDH) and albumin levels in bronchoalveolar lavage (BAL) samples were significantly higher in mice challenged with LABACER01 than in LABACER27-infected animals, indicating greater lung tissue damage. Both strains increased the levels of neutrophils, macrophages, TNF-α, IL-1β, IL-6, KC, MCP-1, IFN-γ, and IL-17 in the respiratory tract and blood, with the effect of LABACER01 more marked than that of LABACER27. In contrast, LABACER27 induced higher levels of IL-10 in the respiratory tract than LABACER01. Genomic analysis revealed that K. pneumoniae LABACER01 and LABACER27 possess virulence factors found in other strains that have been shown to be hypervirulent, including genes required for enterobactin (entABCDEF) and salmochelin (iroDE) biosynthesis. In both strains, the genes of toxin–antitoxin systems, as well as regulators of the expression of virulence factors and adhesion genes were also detected. Studies on the genetic potential of multiresistant K. pneumoniae strains as well as their cellular and molecular interactions with the host are of fundamental importance to assess the association of certain virulence factors with the intensity of the inflammatory response. In this sense, this work explored the virulence profile based on genomic and in vivo studies of hypermucoviscous carbapenem-resistant K. pneumoniae ST25 strains, expanding the knowledge of the biology of the emerging ST25 clone in Argentina.     

Phase equilibria in the Au–In–Sn ternary system

Phase equilibria of the Au–In–Sn system have been investigated by Differential Scanning Calorimetry (DSC), metallographic examination, Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray Spectroscopy (EDS) measurements. The 130 ^°C isothermal section of the phase diagram was studied. The ternary diagram shows six three-phase fields, and one ternary Au₄In₃Sn₃ phase, which melts incongruently at 382 ^°C and shows a homogeneity range between 21 and about 30 at.% In, at constant Au/Sn ratio.     

A Trip to Oz and a Peak Behind the Curtain of Magnesium Batteries

The introduction of the Li‐ion battery has revolutionized the electronics industry due to its high energy density. Magnesium batteries may have the potential to exceed the energy densities of Li‐ion batteries. Herein, the major advancements in magnesium electrochemistry and the challenges that must be overcome to realize a practical magnesium battery are discussed. So too are the controversial realities of current magnesium battery research and their implications.     

The creep experiment and theoretical model analysis of gas- containing coal

A creep experiment of preformed molding coal under different confining pressures were carried out using self-developed 3-triaxial creep loading device for gas-containing coal, which loaded by Shimadzu AGI-250 kN electrical servo-controlled stiffness testing machine. Based on the experimental results, the variation trend of axial deformation under different stress states was studied, and creep failure characteristics of gas-containing coal under different confining pressures were analyzed. The experimental results were identified with seven-component nonlinear viscoelasto-plastic creep model （Hohai model）, and the creep material parameters were obtained. The experimental result complies well with the theoretical value of this model. It indicates that creep constitutive relation of gas-containing coal can be expressed by nonlinear viscoelasto-plastic creep model correctly.     

金属镁中锌的测定

根据国际市场对金属镁的特殊要求,笔者探索出了一套金属镁中锌的检测方法。该方法符合国际要求,而且具有准确、高效的特点。     

Primary Aldosteronism and Resistant Hypertension: A Pathophysiological Insight

Primary aldosteronism (PA) is a pathological condition characterized by an excessive aldosterone secretion; once thought to be rare, PA is now recognized as the most common cause of secondary hypertension. Its prevalence increases with the severity of hypertension, reaching up to 29.1% in patients with resistant hypertension (RH). Both PA and RH are “high-risk phenotypes”, associated with increased cardiovascular morbidity and mortality compared to non-PA and non-RH patients. Aldosterone excess, as occurs in PA, can contribute to the development of a RH phenotype through several mechanisms. First, inappropriate aldosterone levels with respect to the hydro-electrolytic status of the individual can cause salt retention and volume expansion by inducing sodium and water reabsorption in the kidney. Moreover, a growing body of evidence has highlighted the detrimental consequences of “non-classical” effects of aldosterone in several target tissues. Aldosterone-induced vascular remodeling, sympathetic overactivity, insulin resistance, and adipose tissue dysfunction can further contribute to the worsening of arterial hypertension and to the development of drug-resistance. In addition, the pro-oxidative, pro-fibrotic, and pro-inflammatory effects of aldosterone may aggravate end-organ damage, thereby perpetuating a vicious cycle that eventually leads to a more severe hypertensive phenotype. Finally, neither the pathophysiological mechanisms mediating aldosterone-driven blood pressure rise, nor those mediating aldosterone-driven end-organ damage, are specifically blocked by standard first-line anti-hypertensive drugs, which might further account for the drug-resistant phenotype that frequently characterizes PA patients.     

Atomic-Resolution Structures and Mode of Action of Clinically Relevant Antimicrobial Peptides

Global rise of infections and deaths caused by drug-resistant bacterial pathogens are among the unmet medical needs. In an age of drying pipeline of novel antibiotics to treat bacterial infections, antimicrobial peptides (AMPs) are proven to be valid therapeutics modalities. Direct in vivo applications of many AMPs could be challenging; however, works are demonstrating encouraging results for some of them. In this review article, we discussed 3-D structures of potent AMPs e.g., polymyxin, thanatin, MSI, protegrin, OMPTA in complex with bacterial targets and their mode of actions. Studies on human peptide LL37 and de novo-designed peptides are also discussed. We have focused on AMPs which are effective against drug-resistant Gram-negative bacteria. Since treatment options for the infections caused by super bugs of Gram-negative bacteria are now extremely limited. We also summarize some of the pertinent challenges in the field of clinical trials of AMPs.     

萍钢二铁厂提高烧结矿中MgO含量的实践

分析了萍钢将烧结矿中MgO含量提高至3.0%左右后对烧结矿产量和质量的影响,介绍了所采取的相应措施及效果.     

圆高强钢管UHPC梁抗弯性能研究

高强钢管高强混凝土的应用越来越广泛,但目前对于其徐变特性的试验研究较少。该文对15根不同含钢率的高强钢管高强混凝土轴压短柱进行了365 d的收缩和徐变测试,并将试验结果与常用的徐变预测模型MC90、ACI209和MC2010等进行了对比。试验结果表明：高强钢管高强混凝土的徐变系数远小于素混凝土,当加载365 d后,素混凝土的徐变系数是高强钢管高强混凝土的2倍以上;含钢率对钢管混凝土试件的徐变有一定影响,徐变系数随着含钢率的增大而减小。在对比的3种常用徐变预测模型中,MC2010模型的徐变预测结果与试验结果吻合最好,可推荐用于高强钢管高强混凝土的收缩和徐变效应计算。此外,还将高强钢管高强混凝土与普通钢管混凝土的徐变试验结果进行了对比,结果表明,钢管混凝土的徐变随着核心混凝抗压强度的增加而减小。研究成果可为高强钢管高强混凝土轴心受压构件在正常使用阶段的徐变预测及徐变变形控制提供依据。