RC框架梁柱组合件抗震性能试验研究

为提高钢筋混凝土(RC)梁的变形能力,考虑在其塑性铰区采用高延性混凝土(HDC)代替普通混凝土。共设计6个剪跨比为3.6的RC梁试件,包含5个塑性铰区采用HDC的试件和1个RC对比试件。考虑HDC区长度、纵筋配筋率以及配筋方式和梁端配箍率的影响,研究试件在低周反复荷载下的滞回特性、变形能力及耗能能力。结果表明：与RC梁相比,塑性铰区采用HDC后,试件的破坏形态由弯剪破坏向弯曲破坏转变,延性和耗能能力均得到显著提高;纵筋配筋率、配筋方式相同时,在梁端塑性铰区采用HDC,试件的位移延性系数和极限位移角分别提高30%和53%,而同时采用HDC和箍筋时分别相应提高33%和76%;梁端局部采用HDC替换混凝土可减少箍筋用量;梁端塑性铰区的HDC长度对试件延性的影响较小。分别计算塑性铰区采用HDC梁在开裂荷载、屈服荷载、峰值荷载、极限荷载时的顶点位移,其计算值与试验值吻合较好。     

Antibody Therapies Targeting Complex Membrane Proteins

In analyses of protein families that may serve as drug targets, membrane-associated G-protein-coupled receptors (GPCRs) dominate, followed by ion channels, transporters, and—to a lesser extent—membrane-bound enzymes. However, various challenges put such membrane proteins among key groups of underutilized opportunities for the application of therapeutic antibodies. Antibodies hold the promise of exquisite specificity, as they are able to target even specific conformations of a particular membrane protein, as well as adaptability through engineering into various antibody formats. However, the ease of raising and isolating specific, effective antibodies targeting membrane proteins depends on many factors. In particular, the generation of specific antibodies is easier when targeting larger, simpler, extracellular domains with greater uniqueness of amino acid sequence. The rareness of such ideal conditions is illustrated by the limited number of approved biologics for targeting GPCRs and other complex membrane proteins. Challenges in developing antibodies to complex membrane proteins such as GPCRs, ion channels, transporters, and membrane-bound enzymes can be addressed by the design of the antigen, antibody-generation strategies, lead optimization technologies, and antibody modalities. A better understanding of the membrane proteins being targeted would facilitate mechanism-based drug discovery. This review describes the advantages and challenges of targeting complex membrane proteins with antibodies and discusses the preparation of membrane protein antigens and antibody generation, illustrated by select examples of success.     

Fluorescence enhancement from plasmonic Au templates

We have fabricated sub-quarter-micron-patterned Au templates with electron beam lithography, and studied their effect on the fluorescence intensity of immobilized, anti-rabbit IgG antibody labeled with AlexaFluor® 546. Varying the geometry of the structured surface, the plasmon resonances are tuned to match the fluorescence wavelengths and achieve significant fluorescence enhancement. Full electrodynamic simulations were used to understand the optical response and access the quality of the fabricated structures for surface plasmon excitation.     

The orthogonal meshless finite volume method for solving Euler–Bernoulli beam and thin plate problems

In this paper a new method untitled “orthogonal meshless finite volume method” (OMFVM) is developed for solving elastostatic problems in Euler–Bernoulli beam and thin plate. In this method, the weak formulation of a conservation law is discretized by restricting it to a discrete set of test functions. In contrast to the usual finite volume approach, the test functions are not taken as characteristic functions of the control volumes in a spatial grid, but are chosen from a Heaviside step function. The present approach eliminates the expensive process of directly differentiating the OMLS interpolations in the entire domain. This method was evaluated by applying the formulation to a variety of patch test and thin beam problems. The formulation successfully reproduced exact solutions. Numerical examples demonstrate the advantages of the present methods: (i) lower-order polynomial basis can be used in the OMLS interpolations; (ii) smaller support sizes can be used in the OMFVM approach; and (iii) higher accuracies and computational efficiencies are obtained.     

Ion fluxes in medium frequency pulsed DC magnetron sputtering

The ion fluxes which bombard the substrate during deposition by asymmetric medium frequency pulsed DC magnetron sputtering have been measured as a function of substrate position and pulse frequency. It has been found that, particularly at higher pulse frequencies, the ion flux is dominated by very high energy fluxes which are determined by the positive overshoot voltage in the pulse off period. The behaviour of the ion fluxes on the magnetron centre line and in an offset position has been compared and it is shown that on the centre line there is an additional mid energy ion flux which is not present in the offset position and is thought to arise from the ion flow directed along the magnetic field lines from the racetrack region to the substrate or probe position because of the unbalanced magnetron configuration.     

水压机基础梁铸件的制造

针对制造难点进行了合理的工艺设计。采取切实有效的工艺措施成功地铸造出满足设计要求的水压机基础梁铸件。     

锈蚀钢筋混凝土矩形梁截面延性分析

对锈蚀钢筋混凝土梁的延性特征展开研究,结合48根梁(32根锈蚀梁和12根对比试验梁)的试验数据,在平截面假定不再成立的前提下,回归分析得出不同锈蚀程度的梁在钢筋屈服和极限状态时钢筋与混凝土的应变关系,通过此应变关系得到锈蚀梁在钢筋屈服和极限状态时受压区高度的计算表达式,从而得到了锈蚀梁曲率延性系数的计算模型;根据计算模型,绘制不同锈蚀程度梁的M-φ曲线,并分析了不同锈蚀程度梁的延性变化特征及原因。     

在结构受拉区设置钢板的抗裂机理分析

采用经典层合梁理论分析了钢板在结构中对裂缝阻碍的作用,证明了在结构受拉区设置钢板可以更充分的发挥钢材的作用,使得钢板与混凝土共同受力,起到阻碍受拉区域混凝土裂缝产生的作用。     

合宁铁路滁河大桥137m钢混结合梁架设施工技术

介绍了合宁铁路滁河大桥137 m钢混结合梁架设的总体施工方案和施工步骤,具体阐述了现场平面布置、操作平台搭设、水中栈桥施工、行走龙门吊的安装等工艺和方法,并对机械配置、材料投入、人员组织作了说明,对类似工程具有一定指导意义。     

浅析HID电弧管发黑问题

主要探讨了汞灯、金卤灯、钠灯电弧管在使用过程中管壁发黑的问题。以物理化学变化为理论基础,以"电弧管使用后期发黑"和"电弧管初次燃点发黑"为研究对象,结合电弧管生产工艺流程,分析了管壁发黑的根本原因,为解决电弧管管壁早期发黑寻求最佳的解决方法。