Statin Treatment Improves Plasma Lipid Levels but not HDL Subclass Distribution in Patients Undergoing Percutaneous Coronary Intervention

Despite the established efficacy of statin therapy, the risk of cardiovascular events remains high in many patients. We examined high-density lipoprotein (HDL) subclass distribution profiles among statin-treated coronary heart disease (CHD) patients undergoing percutaneous coronary intervention (PCI). Plasma HDL subclasses were measured in 85 patients with established CHD and quantified by two-dimensional gel electrophoresis and immunoblotting. In CHD patients with statin treatment, the mean value of total cholesterol (TC) reached the desirable level and the triacylglycerol level (TAG) was borderline high. Moreover, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), apolipoproteinA-I, and apolipoproteinB-100 levels in these patients resembled those in normolipidemic healthy subjects. The HDL subclass did not show a normal distribution and was characterized by the lower large-sized HDL_2b contents and higher contents of small-sized preβ₁-HDL in CHD patients, compared to those in normolipidemic control subjects. Multiple stepwise regression analysis revealed that the severity of coronary stenosis, determined by the Gensini Score, was significantly and independently predicted by HDL_2b and HDL_3b. Statin therapy was effective in modifying plasma lipids levels, but not adequate as a monotherapy to normalize the HDL subclass distribution phenotype of patients with CHD undergoing PCI. The HDL subclass distribution may aid in risk stratification, especially in patients with CHD and therapeutic LDL-C and HDL-C levels.     

Beckman红外向量定量分析法测定醚化汽油中的醚醇含量

讨论了Beckman向量定量分析法的原理，对该法在测定醚化汽油中醇醚含量中的应用进行了研究，得到了满意的结果．     

Quantification of Mixtures of C2 and C3 Hydroxy Acids and Products of Glycerol Oxidation by High-Performance Liquid Chromatography and Quantitative 13C NMR

The aim of this study was to develop an improved general method for detecting and quantifying mixtures of hydroxy acids and other products of glycerol oxidation in aqueous media, to prevent the confusions that can occur due to similarities and interactions between these compounds depending on media conditions. Standard potential products of glycerol oxidation—glycerol, glyceraldehyde, dihydroxyacetone, glyceric acid, lactic acid, glycolic acid, glyoxylic acid, oxalic acid, tartronic acid, and mesoxalic acid—were analyzed by high-performance liquid chromatography (HPLC) and quantitative ¹³C nuclear magnetic resonance (NMR), in mixtures of known composition. The results obtained were concordant with the known compositions tested. HPLC was more accurate than quantitative ¹³C NMR for simple mixtures, but ¹³C NMR was required for complex mixtures containing dihydroxyacetone and glycerol, oxalic acid and mesoxalic acid, or glyoxylic acid and tartronic acid, pairs of compounds not well separated or detected by HPLC. As proof-of-concept, an unknown mixture generated by glycerol oxidation was analyzed by HPLC and quantitative ¹³C NMR. The results obtained were concordant and allowed accurate determination of the composition of the sample, which contained mesoxalic acid as the major product, with oxalic acid, tartronic acid, and glyceric acid as by-products.     

非均匀结构件材料密度工业CT定量检测方法

采用模拟试验的方法,研究了试件结构变化对CT值及图像噪声的影响。比较了线衰减系数对比法和密度对比法对壳体类非均匀结构件材料密度检测的适用性,给出了线衰减系数对比法中具有普遍使用意义的"等效能量"的获取方法——"残差平方和法"。试验表明,对于壳体类非均匀结构件,密度对比法的测量精度要优于线衰减系数对比法。研究内容对弹药装药工业CT定量检测方法的选择具有较好的指导意义。     

焊缝超声波检测时DAC曲线的制作与应用

分析了传统焊缝超声波检测在灵敏度调节与缺陷定量上的不足,介绍了N5刻槽DAC曲线的两种制作方法,使不同声程处的缺陷都有自己的定量依据,简化了超声检测人员灵敏度调节和缺陷定量的步骤,减少了人员工作量。     

油处理设备与大规模定制的需求分析及案例研究

从国内外润滑油的回收率比较入手,分析了油处理设备的市场需求、生产现状与发展趋势,提出实施大规模定制生产模式的必要性与可行性;并结合某油处理设备制造企业,讨论实施大规模定制的最佳定制点,提出以采用模块化技术辅以建立客户需求信息库与优化供应链的具体实施方案。最后,运用大批量定制生产模式的定量分析方法,对该生产模式的实施所带来的经济效益进行分析,从而进一步验证了实施的必要性。     

Quantitative evaluation of micro-cracks using nonlinear ultrasonic modulation method

Nonlinear acoustic coefficients have a close relationship with structural cracks. A nonlinear ultrasonic modulation method for micro-crack quantitative evaluation is developed. The influence of phase threshold on the crack evaluation is discussed. Ultrasonic modulation using a unilateral incentive model is applied to the quantitative evaluation of micro-cracks for different specimens. The experimental results indicate that the method can be beneficially applied for micro-cracks detection. A proper phase threshold can improve the reliability of the method based on nonlinear ultrasonic modulation. The presented modulation factor can be used to quantitatively evaluate the structural cracks, and it is suitable for small-crack quantitative evaluation.     

影响自适应油源输出量参数的建模与仿真研究

针对某系统的自适应油源液压系统,在分析其结构的基础上,对自适应油源液压系统控制原理进行了数学推导,建立了自适应油源液压系统控制数学模型,绘制了自适应油源控制流程图。利用AMESim仿真软件建立了自适应油源液压系统的仿真模型,仿真了定量元件参数对自适应油源液压系统输出的影响,并对仿真结果进行了分析。仿真结果对自适应油源液压系统故障诊断和系统优化具有很好的参考价值。     

傅立叶变换红外光谱仪（FTIR）在矿物含量分析中的应用

本文介绍了利用傅立叶变换红外光谱仪测量矿物含量的方法。首先利用石英、长石、方解石、白云石、高岭石等14种沉积岩中的常见矿物制作了49组矿物混合物,这些混合物中各矿物的相对含量已知并符合各矿物在沉积岩中的分布规律。然后利用FTIR测量各组混合物中矿物的相对含量,结果表明该方法测量的误差在±2.6%以内。最后列举了2个利用FTIR方法进行矿物定量分析的实例,说明这种方法的精确性以及优势。     

检测重组人血小板生成素含量的改良双抗体夹心ELISA方法的建立

目的建立检测重组人血小板生成素(rhTPO)含量的改良双抗体夹心ELISA方法。方法用棋盘滴定法确定包被单抗、一抗和酶标二抗的最佳工作浓度;绘制标准曲线,确定线性范围、检测限和定量限;检测该方法的准确性(回收率)、精密性和特异性,并与Lowry法检测结果进行比较。结果包被单抗的最佳包被浓度为1.0μg/ml,一抗和酶标二抗的最佳使用浓度分别为1∶5000和1∶10000;检测的线性范围为(125～4000)pg/ml,检测限为75pg/ml,定量限为189pg/ml;不同浓度rhTPO的回收率在(97.0±2.1)%～(105.0±8.5)%之间;6批样品的试验内变异系数在3.2%～8.1%之间,试验间变异系数在5.7%～10.4%之间,特异性良好;与Lowry法检测结果具有良好的相关性。结论已建立检测rhTPO含量的改良双抗体夹心ELISA法,准确性、精密性、特异性良好,可用于rhTPO研究及生产过程中的定量分析。