大系统分解协调在库群防洪优化调度中的应用

文章介绍了大系统分解协调理论,建立了串联、并联库群水库防洪优化调度模型.以澧水流域并联系统为例进行了优化调度计算,并以常规调度方案成果进行了分析比较论证.     

改性己二胺制备TG301环氧树脂室温固化剂

已二胺经与环氧树脂进行羟烷基化及与丙烯腈进行氰乙基化反应达到改善低熔点低毒性．低脆性的综合效果．文中介绍了改性乙二胶固化剂的制备方法，质量指标和有关固化特性等．     

A singular loop transformation framework based on non-singular matrices

In this paper, we discuss a loop transformation framework that is based on integer non-singular matrices. The transformations included in this framework are called Λ-transformations and include permutation, skewing and reversal, as well as a transformation calledloop scaling. This framework is more general than existing ones; however, it is also more difficult to generate code in our framework. This paper shows how integer lattice theory can be used to generate efficient code. An added advantage of our framework over existing ones is that there is a simple completion algorithm which, given a partial transformation matrix, produces a full transformation matrix that satisfies all dependences. This completion procedure has applications in parallelization and in the generation of code for NUMA machines. This work was supported by the Cornell Theory Center, NSF Presidential Young Investigator award #CCR-8958543. by NSF Grant #CCR-9008526, and by a grant from the Hewlett-Packard Company.     

基于Winpcap跨网多网监控系统设计与实现

针对现有网络监控系统存在的不足,分析了Winpcap运行机制,提出了新型网络监控模型,并给出解决方案,新系统具有跨网监控和远程控制的功能。     

基于交流比例积分控制器的单相逆变器

提出一种电感电流、输出电压瞬时值反馈控制和负载电流前馈控制相结合的复合控制策略。在此基础上,研制了一台800W的单相逆变器。实验结果表明,提出的控制策略改善了逆变器输出电压的波形,提高了系统的暂态特性。     

Customer entrepreneurship on digital platforms: Challenges and solutions for platform business models

Drawing on the mixed methods of qualitative research and agent‐based simulation, this study examines: (a) how end‐users use digital platforms to become customer–entrepreneurs undertaking commercial activities on platforms; and (b) how platform providers can convert this customer entrepreneurship into a revenue stream. Considering that end‐users have traditionally been defined as passive and uncharged actors in platform business models, an in‐depth understanding of their commercial activities and the viable revenue model to monetize this emerging customer practice is warranted. Our qualitative study reveals that customer–entrepreneurs make substantial use of platform offerings to advertise their products; communicate with end‐consumers; and accept payments. These commercial activities are largely exercised for free on platforms, even though they could otherwise serve as a source of revenue. On this point, our simulation results identify two pricing models achieving the generation of nearly identical revenues over time. First, platform providers may charge both advertising and transaction fees, which maximize the survival of professional customer–entrepreneurs. Second, platform businesses may levy advertising fees only, which maximizes the survival of informal customer–entrepreneurs operating on a micro‐scale and part‐time basis. This study offers theoretical, methodological, and managerial implications for platform studies.     

除油剂除锈剂发黑剂的进展

从逐渐不采用强酸碱的角度回顾了除油、除锈、发黑及电镀等技术近年的进展情况,介绍和评价了这类技术涉及的一些市售商品,提出了进一步推广应用这些材料必须解决的问题。     

多元QoS约束下电力通信无线资源分配的边缘代理调度方法

为满足不同配电通信业务的服务质量要求,BS需要在时变网络条件下实时优化无线资源。提出一种基于级联深度网络的接入网无线资源边缘代理调度方法,将时频资源和发射功率分配给延迟耐受度不同的业务。核心网采用网元功能与专用硬件设备解耦的软切片方法,在保证负荷在规定时长内可靠切除的同时,提高了核心网服务器对不同业务的时空间复用能力。仿真结果表明,多业务并列运行时RTU与协控子站间的接入时延与TD-LTE专网相比降低40.76%,相邻第一第二信道间的功率泄露比均高于45 dB,满足毫秒级负荷切除业务分路整组动作时延和通信可靠性的要求。     

Identification of Cyclophilin A as a Potential Anticancer Target of Novel Nargenicin A1 Analog in AGS Gastric Cancer Cells

We recently discovered a novel nargenicin A1 analog, 23-demethyl 8,13-deoxynargenicin (compound 9), with potential anti-cancer and anti-angiogenic activities against human gastric adenocarcinoma (AGS) cells. To identify the key molecular targets of compound 9, that are responsible for its biological activities, the changes in proteome expression in AGS cells following compound 9 treatment were analyzed using two-dimensional gel electrophoresis (2-DE), followed by MALDI/TOF/MS. Analyses using chemical proteomics and western blotting revealed that compound 9 treatment significantly suppressed the expression of cyclophilin A (CypA), a member of the immunophilin family. Furthermore, compound 9 downregulated CD147-mediated mitogen-activated protein kinase (MAPK) signaling pathway, including c-Jun N-terminal kinase (JNK) and extracellular signal-regulated protein kinase 1/2 (ERK1/2) by inhibiting the expression of CD147, the cellular receptor of CypA. Notably, the responses of AGS cells to CypA knockdown were significantly correlated with the anticancer and antiangiogenic effects of compound 9. CypA siRNAs reduced the expression of CD147 and phosphorylation of JNK and ERK1/2. In addition, the suppressive effects of CypA siRNAs on proliferation, migration, invasion, and angiogenesis induction of AGS cells were associated with G2/M cell cycle arrest, caspase-mediated apoptosis, inhibition of MMP-9 and MMP-2 expression, inactivation of PI3K/AKT/mTOR pathway, and inhibition of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) expression. The specific interaction between compound 9 and CypA was also confirmed using the drug affinity responsive target stability (DARTS) and cellular thermal shift assay (CETSA) approaches. Moreover, in silico docking analysis revealed that the structure of compound 9 was a good fit for the cyclosporin A binding cavity of CypA. Collectively, these findings provide a novel molecular basis for compound 9-mediated suppression of gastric cancer progression through the targeting of CypA.