Copper‐Free Clickable Coatings

The copper‐catalyzed azide–alkyne 1,3‐dipolar cycloaddition (CuAAC) is extensively used for the functionalization of well‐defined polymeric materials. However, the necessity for copper, which is inherently toxic, limits the potential applications of these materials in the area of biology and biomedicine. Therefore, the first entirely copper‐free procedure for the synthesis of clickable coatings for the immobilization of functional molecules is reported. In the first step, azide‐functional coatings are prepared by thermal crosslinking of side‐chain azide‐functional polymers and dialkyne linkers. In a second step, three copper‐free click reactions (i.e., the Staudinger ligation, the dibenzocyclooctyne‐based strain‐promoted azide–alkyne [3+2] cycloaddition, and the methyl‐oxanorbornadiene‐based tandem cycloaddition?retro‐Diels?Alder (crDA) reaction) are used to functionalize the azide‐containing surfaces with fluorescent probes, allowing qualitative comparison with the traditional CuAAC.     

激光-感应复合熔覆Ni基WC复合层的工艺研究

为了提高熔覆效率与消除熔覆层的裂纹,采用激光-感应复合熔覆的方法在A3表面获得了无气孔与裂纹的Ni基WC复合层。研究了不同的加工参量对复合层质量的影响,结果表明,随着激光比能的增加,粉末面密度增加;在相同的激光比能条件下,随着粉末面密度增加,熔覆层的高度增加,稀释率减小;在相同的粉末面密度条件下,随着激光比能的增加,熔覆层的宽度略有增加。此外,相对于单纯的激光熔覆技术,激光-感应复合熔覆的效率约可以提高5倍。在激光-感应复合熔覆过程中,熔覆层与基材间的温度梯度大大降低,这是Ni基WC复合层无裂纹的关键原因。     

机械化学促成可调谐光-电多功能响应二维杂化钙钛矿材料

二维有机-无机杂化钙钛矿因在光伏、光电子等领域的巨大应用潜力而备受关注.此外,该类材料具有突出的结构可调性和材料稳定性,为功能性质的设计调控及器件应用提供了丰富的材料设计平台.然而,将多种物理通道的性质整合实现材料的多功能性仍具有挑战性,而对其进行快速有效的调节更是难上加难.迄今为止,尚未成功实现可调谐的光电多通道响应...     

Chl1, an ATP-Dependent DNA Helicase,Inhibits DNA:RNA Hybrids Formation at DSB Sites to Maintain Genome Stability in S. pombe

As an ATP-dependent DNA helicase, human ChlR1/DDX11 (Chl1 in yeast) can unwind both DNA:RNA and DNA:DNA substrates in vitro. Studies have demonstrated that ChlR1 plays a vital role in preserving genome stability by participating in DNA repair and sister chromatid cohesion, whereas the ways in which the biochemical features of ChlR1 function in DNA metabolism are not well understood. Here, we illustrate that Chl1 localizes to double-strand DNA break (DSB) sites and restrains DNA:RNA hybrid accumulation at these loci. Mutation of Chl1 strongly impairs DSB repair capacity by homologous recombination (HR) and nonhomologous end-joining (NHEJ) pathways, and deleting RNase H further reduces DNA repair efficiency, which indicates that the enzymatic activities of Chl1 are needed in Schizosaccharomyces pombe. In addition, we found that the Rpc37 subunit of RNA polymerase III (RNA Pol III) interacts directly with Chl1 and that deletion of Chl1 has no influence on the localization of Rpc37 at DSB site, implying the role of Rpc37 in the recruitment of Chl1 to this site.     

钢筋接驳器与柱翼缘板的焊接

阐述了钢筋接驳器与柱翼缘板的可焊性、焊脚尺寸的确定和焊接过程应注意的问题,并做了详细介绍。     

Research on a New Hybrid System of a Tyre Crane Using Supercapacitors

Research on a hybrid system of a crane is a focus which considers environmental protection and energy saving.A new environmental protection and energy saving hybrid system of tyre crane.which utilizes supercapacitors as the energy store device,is presented.Analyzing the pdneiple of supercapacitors,the model of the crane's hybrid system is set up in this paper,and the model of main blocks are established.Through simulation analyzing,the energy saving result of the new hybrid system is obtained,and the good application value of the new hybrid system is explained.     

Theranostic Agent Combining Fullerene Nanocrystals and Gold Nanoparticles for Photoacoustic Imaging and Photothermal Therapy

Developing photoactivatable theranostic platforms with integrated functionalities of biocompatibility, targeting, imaging contrast, and therapy is a promising approach for cancer diagnosis and therapy. Here, we report a theranostic agent based on a hybrid nanoparticle comprising fullerene nanocrystals and gold nanoparticles (FGNPs) for photoacoustic imaging and photothermal therapy. Compared to gold nanoparticles and fullerene crystals, FGNPs exhibited stronger photoacoustic signals and photothermal heating characteristics by irradiating light with an optimal wavelength. Our studies demonstrated that FGNPs could kill cancer cells due to their photothermal heating characteristics in vitro. Moreover, FGNPs that are accumulated in tumor tissue via the enhanced permeation and retention effect can visualize tumor tissue due to their photoacoustic signal in tumor xenograft model mice. The theranostic agent with FGNPs shows promise for cancer therapy.     

FRP与混凝土组合结构研究综述

提出一种在塑性铰区域采用高延性纤维增强水泥基复合材料(ECC)替代混凝土来改善FRP筋-钢筋增强混凝土柱抗震性能的新方法。对FRP筋-钢筋增强ECC-混凝土构件进行了低周往复荷载试验,系统地考察了基体材料、筋材种类、轴压比对构件破坏模态、裂缝模式、承载力、残余变形、延性和耗能能力的影响。结果表明,将ECC替代塑性铰区域混凝土能够有效避免FRP筋的受压屈曲,进而显著提升组合柱的抗震性能。与钢筋增强ECC-混凝土组合柱相比,复合筋增强ECC-混凝土组合柱的残余变形明显更小,且屈服后的刚度更高。随着轴压比的增大,构件极限强度升高但变形能力降低。通过有限元参数分析可知,组合柱的承载力和变形能力均随着ECC抗压强度及总配筋率的增大而增大;在总配筋率不变的情况下,FRP筋占比越高,构件的延性越好。     

组合转子同步电机稳定性探讨

组合转子同步电机由轴向叠片各向异性(ALA)磁阻段和面贴式永磁(SPM)段组合而成,磁路各自独立.为研究组合转子电机在开环V/f控制方式下的稳定性,采用小信号分析方法,探讨无惯性阻尼器和附加机械惯性阻尼器的组合式转子电机SPM段占转子全长之比k与电机稳定性的关系.研究结果表明,无惯性阻尼器的组合式转子电机,k值增大,稳定频率范围扩宽不明显;附加惯性阻尼器,选择合适的惯量盘惯量,调节阻尼器的粘性阻尼系数能明显扩宽稳定频率范围,且k和惯量盘惯量越大,阻尼器的粘性阻尼系数调节范围越宽,电机的稳定性越好.     

矿物绝缘电缆铜带纵包氩弧焊焊接连续轧制生产工艺

简述了矿物绝缘电缆铜带纵包氩弧焊焊接连续轧制的生产工艺,并对该生产工艺中可加硅油氧化镁粉运用、定芯管的设计、氩弧焊焊接、轧辊轧制以及中频感应退火作了描述,同时对连续生产过程中相关工艺作了说明。