Fluctuating NMDA Receptor Subunit Levels in Perirhinal Cortex Relate to Their Dynamic Roles in Object Memory Destabilization and Reconsolidation

Reminder cues can destabilize consolidated memories, rendering them modifiable before they return to a stable state through the process of reconsolidation. Older and stronger memories resist this process and require the presentation of reminders along with salient novel information in order to destabilize. Previously, we demonstrated in rats that novelty-induced object memory destabilization requires acetylcholine (ACh) activity at M₁ muscarinic receptors. Other research predominantly has focused on glutamate, which modulates fear memory destabilization and reconsolidation through GluN2B- and GluN2A-containing NMDARs, respectively. In the current study, we demonstrate the same dissociable roles of GluN2B- and N2A-containing NMDARs in perirhinal cortex (PRh) for object memory destabilization and reconsolidation when boundary conditions are absent. However, neither GluN2 receptor subtype was required for novelty-induced destabilization of remote, resistant memories. Furthermore, GluN2B and GluN2A subunit proteins were upregulated selectively in PRh 24 h after learning, but returned to baseline by 48 h, suggesting that NMDARs, unlike muscarinic receptors, have only a temporary role in object memory destabilization. Indeed, activation of M₁ receptors in PRh at the time of reactivation effectively destabilized remote memories despite inhibition of GluN2B-containing NMDARs. These findings suggest that cholinergic activity at M₁ receptors overrides boundary conditions to destabilize resistant memories when other established mechanisms are insufficient.     

Mobile learning in chemical engineering: An outlook based on case studies

In the context of the electronic learning (E-learning) methodology, mobile learning (M-learning) focuses on the use of portable technology (such as mobiles or tablets) and the mobility of students. E-learning, and particularly M-learning, can be implemented in combination with other pedagogical methodologies for chemical engineering teaching and learning. We can consider that the vast majority of undergraduates own personal mobile devices nowadays. Moreover, many case studies have shown that M-learning is an effective methodology to capture students’ attention and to actively engage them in the learning process. In most cases, lecturers have reported an improvement in both academic performance and qualifications and have expressed a favourable opinion towards this type of initiative in surveys. In line with the increasing interest in the incorporation of E-learning, this review discusses cases studies based on M-learning within the field of chemical engineering teaching through different technological platforms and apps which can be installed or directly used on mobile devices. All the platforms described in this work offer a free version, emphasizing the possibility of extending this methodology within the university with no need for additional economic resources.     

SIMULATION AND ESTIMATION OF LONG MEMORY CONTINUOUS TIME MODELS

Abstract. Some general properties of long memory continuous time processes are recalled or proved. Methods of simulation are studied. A comparison with the usual discrete time autoregressive fractionally integrated moving-average filter is made and illustrations are provided. Then, two methods of estimation of the parameters of such a model from a discrete sample are studied, both theoretically and empirically, with Monte Carlo experiments.     

Cu-Zn-Al形状记忆合金直接淬火和分级淬火后马氏体稳定性的研究SCIEI

用透射电镜,X射线衍射仪和电阻法研究了Cu-14.84wt-％Zn-7.75wt-％Al形状记忆合金在直接淬火和分级淬火后马氏体的稳定性。试验结果表明,直接淬火和分级淬火(150℃,2min)后于室温时效约3h的马氏体均为M18R结构,但刚直接淬火后马氏体并不稳定,其某些衍射峰位置和电阻率均随室温时效而变化;而分级淬火(150℃,2min)后马氏体是稳定的,其所有衍射峰位置和电阻率几乎不随室温时效而变化。上述结果可用“马氏体再有序化机制”解释。     

TWO KINDS OF VARIANT IN SHAPE MEMORY MATERIAL

In shape memory materials,that have been trained to have a two way shape memory effect(TWSM),themartensitic variants are classified into two groups,i.e.,preferentially oriented variants and self-accommodatingvariants.Applied stress may promote or constrain the transition of preferentially oriented variants and so changetransformation temperatures but has no essential effect on self-accommodating variants.According to the pointof view mentioned above,some experimental phenomena during thermocycling of a TWSM device may be ex-plained,such as the absence of synchronization between the plot of resistance change.temperature and the plotof memory strain vs.temperature.     

全球铝轧制工业概览系列综述之九——日本神户钢铁公司真冈铝板带轧制厂

对日本神户钢铁公司枥木县真冈轧制厂的方方面面作了较全面的介绍，并对神户钢铁公司与美国铝业公司的合资企业－－神钢－美铝铝业有限公司作了附带的描述。这两家企业都是从上世纪70年代以来新建的高起点、高水平、高标准、高质量的世界级的铝板带轧制厂，前者的建设时间历20余年，是一步一步壮大的，原来（1＋3）式热连轧生产线，后改为（1＋4）式的，还有进一步改为（1＋5）式的余地。这是一个综合性强的铝板带加工厂，除生产罐料处，还可生产各种热处理可强化的硬合金板带材。该厂可作为中国今后建设全新的大型现代化铝板带轧制工程的模式。     

高效动态存储再分配方案与实现

为提高大小和数量都不确定的数据动态存储的空间利用率和处理速度,针对常规系统动态存储分配存在的问题,提出一种高效的动态存储再分配方案。通过减少系统动态存储分配的执行次数,在有效提高存储空间利用率的同时,提高存储空间动态分配的速度,给出动态存储再分配方案的具体实现算法,用实际数据对其性能进行测试。测试结果表明,该方案能节省36％至75％的系统存储空间,分配速度提高了20至50倍。     

计算机编程语言与输入设备的发展问题初探

现代化建设事业的发展离不开计算机水平的提高。计算机编程语言作为人与机器沟通的桥梁,在计算机系统里有着非常重要的地位。本文从探讨计算机编程语言的概念出发,详细阐述了计算机编程语言所包含的内容和基本分类。接着笔者又深入分析了计算机输入设备的发展问题。最后,针对计算机编程语言和输入之间的联系问题,笔者做了观点性和理论性的论述分析。     

计算机内存的优化及管理浅析

信息总量、网络浏览人数以及人们对网络享受需求的增加,促使着信息制作水平的提高,制作水平的提高在给人们带来了更好的视觉和听觉享受的同时,也对计算机的硬件系统提出了巨大的考验.计算机内存作为计算机硬件系统的重要组成部分,能否对内存做好合理的划分,对计算机的体验具有重要的意义.